Optimal Screening and Discovery of Sparse Signals with Applications to Multistage High Throughput Studies
稀疏信号的最优筛选与发现:多阶段高通量研究应用AI 解读 ↓
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稀疏信号的最优筛选与发现:多阶段高通量研究应用AI 解读 ↓
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Summary A common feature in large-scale scientific studies is that signals are sparse and it is desirable to narrow down significantly the focus to a much smaller subset in a sequential manner. We consider two related data screening problems: one is to find the smallest subset such that it virtually contains all signals and another is to find the largest subset such that it essentially contains only signals. These screening problems are closely connected to but distinct from the more conventional signal detection or multiple-testing problems. We develop phase transition diagrams to characterize the fundamental limits in simultaneous inference and derive data-driven screening procedures which control the error rates with near optimality properties. Applications in the context of multistage high throughput studies are discussed.
高维线性回归的统一谱分析:去偏与阈值化
We use spectral analysis to establish a unified theory of debiasing, thresholding, and simultaneous inference for high-dimensional linear regression with ill-conditioned designs. The methods include Ridge regression, spectral cut-off, and iterative and dynamical regression procedures. A common debiasing procedure uses two applications of the original linear algorithm with fixed parameters. Spectral analysis shows that debiasing squares the residual, while implementations…
Uniform confidence bands are widely used in empirical analysis for uncertainty qualification of nonparametric inference of unknown functions. A variety of simple implementation methods, including multiplier bootstrap, have been proposed and theoretically justified. However, an implementation over a literally continuous index set is generally computationally infeasible, and practitioners therefore compute the critical value by evaluating the statistic on a finite evaluation…
We study nonparametric inference for a continuous-treatment causal dose-response curve and its first derivative under unmeasured confounding, using treatment- and outcome-inducing proxies. We establish a proximal doubly robust pseudo-outcome whose conditional mean given treatment equals the dose-response curve whenever either bridge function is correctly specified. Their (smoothed) efficient influence function representations lead to cross-fitted local-polynomial estimators…
自删失模型下信息性缺失的纵向因果推断
Longitudinal observational data are often subject to informative missingness. For example, in healthcare research using electronic health records, covariates and outcomes are measured only when patients interact with the healthcare system. Whether these data are observed usually depends on the unobserved variable values themselves, introducing a common form of data missing not at random. We develop identification and estimation methods for the effects of longitudinal…
复杂调查设计下的函数型响应对标量协变量回归
Large health surveys increasingly collect high-dimensional functional data from wearable devices, and function on scalar regression (FoSR) is used to quantify the relationship between these functional outcomes and scalar covariates like age and sex. However, existing methods for FoSR fail to account for complex survey design. We introduce inferential methods for FoSR with complex survey designs. The approach combines fast univariate inference (FUI) developed for functional…
通过正交化自适应估计发现存在混杂的时间序列因果滞后结构
Finding which variables cause which others in multivariate time series, and at what lags, is central to science and policy, yet existing methods force a choice between flexible confounder adjustment, data-driven lag selection, and inference that controls the false discovery rate (FDR). ORACLE-VARX does all three in one pipeline. First, double/debiased machine learning (DML) removes nonlinear confounder effects from the outcomes and the lagged series. Second, adaptive causal…