Bootstrap confidence bands for sojourn distributions in multistate semi-Markov models with right censoring
右删失多状态半马尔可夫模型中停留分布的自助法置信带AI 解读 ↓
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右删失多状态半马尔可夫模型中停留分布的自助法置信带AI 解读 ↓
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Transient semi-Markov processes have traditionally been used to describe the transitions of a patient through the various states of a multistate survival model. A survival distribution in this context is a sojourn through the states until passage to a fatal absorbing state or certain endpoint states. Using complete sojourn data, this paper shows how such survival distributions and associated hazard functions can be estimated nonparametrically and also how nonparametric bootstrap pointwise confidence bands can be constructed for them when patients are subject to independent right censoring from each state during the sojourn. Limitations to the estimability of such survival distributions that result from random censoring with bounded support are clarified. The methods are applicable to any sort of sojourn through any finite state process of arbitrary complexity involving feedback into previously occupied states.