A New Central Limit Theorem for the Augmented IPW Estimator: Variance Inflation, Cross-Fit Covariance and Beyond
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增广逆概率加权估计量的新中心极限定理:方差膨胀与交叉拟合协方差AI 解读 ↓
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Estimation of the average treatment effect (ATE) is a central problem in causal inference. In recent times, inference for the ATE in the presence of high-dimensional covariates has been extensively studied. Among the diverse approaches that have been proposed, augmented inverse probability weighting (AIPW) with cross-fitting has emerged a popular choice in practice. In this work, we study this cross-fit AIPW estimator under well-specified outcome regression and propensity score models in a high-dimensional regime where the number of features and samples are both large and comparable. Under assumptions on the covariate distribution, we establish a new central limit theorem for the suitably scaled cross-fit AIPW that applies without any sparsity assumptions on the underlying high-dimensional parameters. Our CLT uncovers two crucial phenomena among others: (i) the AIPW exhibits a substantial variance inflation that can be precisely quantified in terms of the signal-to-noise ratio and other problem parameters, (ii) the asymptotic covariance between the pre-cross-fit estimators is non-negligible even on the root-n scale. These findings are strikingly different from their classical counterparts. On the technical front, our work utilizes a novel interplay between three distinct tools--approximate message passing theory, the theory of deterministic equivalents, and the leave-one-out approach. We believe our proof techniques should be useful for analyzing other two-stage estimators in this high-dimensional regime. Finally, we complement our theoretical results with simulations that demonstrate both the finite sample efficacy of our CLT and its robustness to our assumptions.
组间不平衡下的风险异质性稳健推断
Population-level heterogeneity is ubiquitous in biomedical data, where differences across demographic or clinical subgroups can substantially alter risk patterns. For example, in intensive care unit (ICU) studies, the mortality risk associated with specific admission diagnoses can vary across ethnic groups. Existing approaches for detecting risk heterogeneity are often sensitive to baseline model misspecification and regularization bias, both of which commonly arise in…
The conditional average treatment effect (CATE) is frequently estimated in clinical studies to refute a homogeneous treatment effect hypothesis. Under this regime, all patients making up the population experience identical benefit from a given treatment relative to a comparator. Uncovering heterogeneous treatment effects through inference about the CATE, however, requires that covariates truly modifying the treatment effect be reliably collected at baseline. CATE-based…
IV-LASSO 的工具变量字典与惩罚选择
Estimating the first stage of an instrumental variables (IV) model with the least absolute shrinkage and selection operator (LASSO) requires choosing a dictionary of technical instruments and a penalty level. First-order asymptotic theory offers no guidance on these choices, as any consistent implementation yields a structural parameter estimator with the same limiting distribution. In finite samples, however, these choices can have a substantial impact on the resulting…
嵌套工具变量分析:转换者平均处理效应及可推广性
Instrumental variables (IVs) are widely used to estimate causal effects from non-randomized data. A canonical example is a randomized trial with noncompliance, in which the randomized treatment assignment serves as an IV for the non-ignorable treatment received. Under a monotonicity assumption, a valid IV nonparametrically identifies the average treatment effect among a latent complier subgroup, whose generalizability is often under debate. In many studies, there exist…
Traditional machine learning relies on explicit models and domain assumptions, often limiting flexibility and interpretability. We introduce a "model-free" framework of instance-based learning using surprisal (information theoretic uncertainty) to directly analyze and perform inferences from raw data, eliminating distribution modeling, reducing bias, and enabling efficient updates including direct edits and deletion of training data. By quantifying relevance through…
自删失模型下信息性缺失的纵向因果推断
Longitudinal observational data are often subject to informative missingness. For example, in healthcare research using electronic health records, covariates and outcomes are measured only when patients interact with the healthcare system. Whether these data are observed usually depends on the unobserved variable values themselves, introducing a common form of data missing not at random. We develop identification and estimation methods for the effects of longitudinal…