Principal stratification with continuous treatments and continuous post-treatment variables
连续处理与连续处理后变量的主分层分析AI 解读 ↓
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连续处理与连续处理后变量的主分层分析AI 解读 ↓
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Principal stratification (PS) is a commonly used approach for understanding the mechanisms through which a treatment affects an outcome. The goal of this work is to extend the PS framework to studies with continuous treatments, which introduces a number of both challenges and opportunities in terms of defining causal effects and performing inference. This manuscript provides multiple key methodological contributions: 1) we introduce principal causal estimands for continuous treatments that provide insights into different causal mechanisms, 2) we show that nonparametric identification is possible under a principal ignorability assumption, but only under a restrictive assumption on the joint distribution of potential mediators, which can be dropped under mild parametric assumptions, 3) we utilize nonparametric Bayesian models for the joint distribution of the potential mediating variables to ensure our approach is robust to model misspecification, and 4) we provide theoretical justification for utilizing an outcome model to identify the joint distribution of the potential mediating variables, and show that this is only possible if a principal ignorability assumption is violated. Lastly, we apply our methodology to a novel study of the relationship between the economy and arrest rates, and how this is potentially mediated by police capacity.
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Randomized experiments with ordinal outcomes are common across scientific applications, but conventional causal estimands such as the average treatment effect are difficult to interpret because ordinal categories lack meaningful numerical spacing. Two interpretable estimands, the probabilities that the treatment is beneficial and strictly beneficial, depend on the joint distribution of the potential outcomes and are therefore not identifiable from observed data. The sharp…
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Many studies expose units to several binary treatments at once and record several correlated outcomes, yet analysts usually estimate one treatment's average effect on one outcome at a time -- discarding how treatments interact and how their effects vary across units. We introduce the factorial multivariate Bayesian causal forest, a Bayesian nonparametric model that decomposes the factorial response surface over the treatment lattice into a prognostic sum-of-trees plus one…
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Causal inference is often focused on average effects, which can hide important aspects of the effect distributions. Here we consider the entire posterior effects distribution by estimating full counterfactual outcome distributions. We propose a methodology for inference on counterfactual distributions which builds upon the martingale posterior framework of Fong et al. (2023). This provides a highly flexible approach to estimating densities, distribution functions, and…
处理后混杂下集群随机试验因果机制的贝叶斯非参数识别与估计
Causal mediation analysis in cluster-randomized trials (CRTs) is essential for explaining how cluster-level interventions affect individual outcomes, yet it is complicated by interference, post-treatment confounding, and hierarchical covariate adjustment. We develop a Bayesian nonparametric framework that simultaneously accommodates interference and a post-treatment confounder that precedes the mediator. Identification is achieved through a multivariate Gaussian copula that…
终末事件截断复发事件的主层分析:嵌套贝叶斯非参数方法
Recurrent events often serve as key endpoints in clinical studies but may be prematurely truncated by terminal events such as death, creating selection bias and complicating causal inference. To address this challenge, we develop a Bayesian nonparametric framework to address potential selection bias due to truncation by death within the continuous-time principal stratification framework. We introduce causal estimands for recurrent events in the presence of a terminal event…