MediEncoder: Nonlinear Representation Learning for High-Dimensional Causal Mediation Analysis
MediEncoder:高维因果中介分析的非线性表示学习AI 解读 ↓
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MediEncoder:高维因果中介分析的非线性表示学习AI 解读 ↓
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Causal mediation analysis decomposes a treatment effect into indirect pathways through mediators and direct pathways not operating through them. Modern biomedical studies often involve high-dimensional covariates and mediators that are noisy proxies for lower-dimensional latent biological processes. Existing methods typically rely on sparsity, linear factor models, or ignore the connection among variables in the learned representations, which can be restrictive when measurements are nonlinear and covariate and mediator factors are structurally dependent. We propose MediEncoder, a representation-learning framework for nonlinear high-dimensional mediation analysis. MediEncoder jointly learns low-dimensional covariate and mediator representations using a coupled encoder-decoder architecture with a cross-factor network that links treatment and covariate representations to mediator representations. The learned features are then used in a cross-fitted efficient influence function-based estimator of natural direct and indirect effects. The resulting estimator is multiply robust and asymptotically normal under suitable regularity conditions. Simulations show that MediEncoder improves estimation accuracy over competing dimension-reduction approaches, and an application to Alzheimer's Disease Neuroimaging Initiative data illustrates its utility in high-dimensional biomedical causal mediation analysis.
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连接局部与总体因果效应:近端工具变量方法
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采用局部—全局收缩的非正态变换有向无环图半参数贝叶斯结构学习
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多中介整群随机试验的因果中介分析:溢出分解、识别与有效推断
Causal mediation analysis in cluster-randomized trials (CRTs) is complicated by the presence of multiple mediators, intracluster correlation, and within-cluster interference. Existing mediation methods often fall short in accommodating these features simultaneously, and semiparametric efficient estimators that fully address them remain unavailable. We develop a unified framework that defines a class of mediation effect estimands, including exit indirect effects, exit…
算法干扰下的治疗效应估计:结构化神经网络方法
Online user-generated content platforms allocate billions of dollars of promotional traffic through algorithms in two-sided marketplaces. To evaluate updates to these algorithms, platforms frequently rely on creator-side randomized experiments. However, because treated and control creators compete for exposure, such experiments suffer from algorithmic interference: exposure outcomes depend on competitors' treatment status. We show that commonly used difference-in-means…