Simple and reliable estimators of coefficients of interest in a model with high-dimensional confounding effects
高维混杂效应模型中目标系数的简便估计AI 解读 ↓
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高维混杂效应模型中目标系数的简便估计AI 解读 ↓
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Often an investigator is interested in a single parameter or low-dimensional parameter vector (e.g. a treatment effect) in a regression model, rather than in the full set of regression coefficients. There may also be a relatively high-dimensional set of potential explanatory variables other than the effect of interest which, if omitted, could bias the estimate of the parameter of interest. However there may be too many such variables to include all of them without substantial efficiency loss. We suggest a simple, easily computed estimator for this case, using principal components to compute auxiliary regressors from the set of potential controls, and establish the limit properties of the estimator allowing for dependence and heterogeneity as well as increasing dimension of the set of controls. We also provide finite-sample evidence on the performance of the estimator where principal components are selected in a one-dimensional search using an appropriate information criterion as stopping rule for the number of components. The results suggest that the estimator has practical usefulness in small samples.
连接局部与总体因果效应:近端工具变量方法
Instrumental variable (IV) methods address treatment endogeneity, but with non-compliance and heterogeneous treatment effects a binary instrument generally identifies the local average treatment effect (LATE) among compliers rather than the population average treatment effect (ATE). When treatment effects and compliance probabilities are heterogeneous and dependent through latent factors, the ATE need not be identified by IV variation alone. We develop a proximal…
固定阶数 PCA:因子数量高估时的理论
We develop asymptotic theory for principal component analysis (PCA) of a high-dimensional factor model in which the working dimension $R$ is fixed and only required to satisfy $R \ge r$, where $r$ is the true number of factors. Building on anisotropic local laws from random matrix theory, we show that the ``extra'' empirical eigencomponents beyond the $r$-th are asymptotically noise-governed, incoherent, and nearly orthogonal to the factor loadings. We introduce two…
高维暴露与高维中介模型的统计推断
High-dimensional mediation analysis has gained increasing interest in various fields, particularly in genetic and medical research. Compared with existing works that focus mainly on high-dimensional mediators, this paper advocates a new framework of Partial Regularization-based Inference for Mediation Effects (PRIME) when both exposures and mediators are high-dimensional. Estimated direct and indirect effects are established using a group-wise partially penalized least…
贝叶斯替代混杂变量的收缩先验
Multi-cause observational studies contain information about unmeasured confounding through the dependence structure among causes. However, literal imputation of the unobserved confounder is often more complex than learning a lower-dimensional substitute score that preserves the shared assignment variation needed for stable causal adjustment. The deconfounder (Wang and Blei, 2019) and related substitute confounder methods exploit this idea, but flexible assignment models can…
MediEncoder:高维因果中介分析的非线性表示学习
Causal mediation analysis decomposes a treatment effect into indirect pathways through mediators and direct pathways not operating through them. Modern biomedical studies often involve high-dimensional covariates and mediators that are noisy proxies for lower-dimensional latent biological processes. Existing methods typically rely on sparsity, linear factor models, or ignore the connection among variables in the learned representations, which can be restrictive when…
通过因果表征学习构建可解释的深度生成模型
Recent developments in generative artificial intelligence (AI) rely on machine learning techniques such as deep learning and generative modeling to achieve state-of-the-art performance across wide-ranging domains. These methods’ surprising performance is due in part to their ability to learn implicit “representations” of complex, multi-modal data. Unfortunately, deep neural networks are notoriously black boxes that obscure these representations, making them difficult to…