Adjusting Treatment Effect Estimates by Post-Stratification in Randomized Experiments
随机实验中通过后分层调整处理效应估计AI 解读 ↓
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Summary Experimenters often use post-stratification to adjust estimates. Post-stratification is akin to blocking, except that the number of treated units in each stratum is a random variable because stratification occurs after treatment assignment. We analyse both post-stratification and blocking under the Neyman–Rubin model and compare the efficiency of these designs. We derive the variances for a post-stratified estimator and a simple difference-in-means estimator under different randomization schemes. Post-stratification is nearly as efficient as blocking: the difference in their variances is of the order of 1/n2, with a constant depending on treatment proportion. Post-stratification is therefore a reasonable alternative to blocking when blocking is not feasible. However, in finite samples, post-stratification can increase variance if the number of strata is large and the strata are poorly chosen. To examine why the estimators’ variances are different, we extend our results by conditioning on the observed number of treated units in each stratum. Conditioning also provides more accurate variance estimates because it takes into account how close (or far) a realized random sample is from a comparable blocked experiment. We then show that the practical substance of our results remains under an infinite population sampling model. Finally, we provide an analysis of an actual experiment to illustrate our analytical results.
Background: Generalized Odds (Gen Odds) provide summaries for ordinal outcomes without requiring the proportional odds assumption. However, conventional Gen Odds compares independently drawn treatment and control outcomes and targets a population-level contrast rather than an individual-level contrast. We developed an individual-level causal formulation of Gen Odds and examined its identification. Methods: We defined the Causal Gen Odds using the joint distribution of…
We develop a semiparametric continuous time inferential framework for testing cumulative treatment effects, including both immediate and carryover effects. The latent state process is modeled by an ordinary differential equation (ODE) whose drift depends on state and treatment, while the observed data are noisy measurements of this latent state at irregular, multi resolution time points. We define the average treatment effect (ATE) as the difference of expected cumulative…
当处理发生溢出:时空因果效应估计的神经网络框架
Real-world public health policies are often enacted by local jurisdictions, but their effects can ripple through connected populations. For causal evaluation, this creates a difficult spatiotemporal problem: intermittent policy updates create path-level treatments, and because spillover depends on neighboring treatment paths along with the focal-unit's own history, controlling time-varying confounding requires high-dimensional, multimodal information from both sources. To…
时空干扰下用于实验的聚类切换设计
We consider experimentation in the presence of non-stationarity, inter-unit (spatial) interference, and carry-over effects (temporal interference), where we wish to estimate the global average treatment effect (GATE), the difference between average outcomes having exposed all units at all times to treatment or to control. We suppose spatial interference is described by a graph, where a unit's outcome depends on its neighborhood's treatments, and that temporal interference is…
We study inference for continuous linear functionals of solutions to ill-posed inverse problems, including Euclidean parameters arising in nonparametric instrumental variables, proximal causal inference, and shadow-variable models. Although pointwise root-$n$ inference is possible under standard conditions, we show that this need not translate into locally reliable inference. Under a model imposing only minimal regularity conditions, the target is Hellinger discontinuous…
Motivation: Mediation analysis is an important tool for elucidating causal mechanisms in biomedical research and has recently gained increasing attention in microbiome studies. Motivated by a microbiome study of acute myeloid leukemia (AML) patients, we investigate whether the effect of induction chemotherapy intensity on infection status is mediated through gut microbial taxa. This problem poses substantial methodological challenges due to the high dimensionality, zero…