Debiasing the estimate of treatment effect on the treated with time-varying counfounders
存在时变混杂因素时的已处理者平均处理效应去偏估计AI 解读 ↓
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存在时变混杂因素时的已处理者平均处理效应去偏估计AI 解读 ↓
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With the increased availability of large health databases comes the opportunity of evaluating treatment effect on new data sources.Through these databases time-dependent outcomes can be analysed as events that can be measured using counting processes. Estimating average treatment effect on the treated (ATT) requires modelling of time-varying covariate and time-dependent treatment and outcome. Gran et al. proposed an easy-to-implement method based on additive intensity regression to estimate ATT. We introduce a debiased estimate of the ATT based on a generalization of the Gran's model for a potentially repeated outcome and in the presence of multiple time-dependent covariates and baseline covariates. Simulation analyses show that our corrected estimator outperforms Gran's uncorrected estimator. Our method is applied to intensive care real-life data from MIMIC-III databases to estimate vasoppressors effect on patients with sepsis.
当处理发生溢出:时空因果效应估计的神经网络框架
Real-world public health policies are often enacted by local jurisdictions, but their effects can ripple through connected populations. For causal evaluation, this creates a difficult spatiotemporal problem: intermittent policy updates create path-level treatments, and because spillover depends on neighboring treatment paths along with the focal-unit's own history, controlling time-varying confounding requires high-dimensional, multimodal information from both sources. To…
估计纵向因果剂量反应关系的贝叶斯框架
Existing causal methods for time-varying exposure and time-varying confounding focus on estimating the average causal effect of a time-varying binary treatment on an end-of-study outcome, offering limited tools for characterizing marginal causal dose-response relationships under continuous exposures. We propose a scalable, nonparametric Bayesian framework for estimating marginal longitudinal causal dose-response functions with repeated outcome measurements. Our approach…
平均处理效应局部化:合成控制中的投影方法
Many real-world policies and business interventions require assessing short-term effects to inform timely decisions, even though most causal inference methods focus on long-term average treatment effects. In this article, we introduce average treatment effect localization (ATEL), which captures localized, short-term policy impacts in panel data settings with a single treated unit and provides early indicators of policy impact. To accommodate both time-varying and nonlinear…
时变协变量下交错双重差分处理效应的双重稳健估计
With staggered adoption, difference-in-differences (DiD) analyses define the average treatment effect on the treated (ATT) at the group-period level and aggregate it into groupwise, periodwise, dynamic, and overall effects. We study a period-by-period version of conditional parallel trends, with covariates unaffected by treatment while allowing covariates to shift the trends in untreated potential outcomes. We propose an augmented inverse probability weighting (AIPW)…
目标试验模拟中的时间划分
In target trial emulation, the treatment strategies that patients follow are inferred from the treatments they actually receive in routine care. However, in most settings, the outcome may preclude the observation of planned treatment, giving rise to immortal time bias through misclassification of treatment strategy, while markers of treatment response may influence subsequent treatment decisions, giving rise to time-varying confounding. A key step toward unbiased treatment…
含时变中介变量与滞后结果的双重差分模型
We study difference-in-differences (DiD) designs in which a binary treatment changes an endogenous time-varying (continuous, discrete, or mixed) mediator that in turn affects an outcome. We allow for the inclusion of lagged outcomes in the model. Under our model assumptions, we show that the usual DiD estimand mixes the average direct effect on the treated, the average indirect effect, and a trend bias term. A two-way fixed effects (TWFE) regression that controls for the…