Estimation of the Number of Spiked Eigenvalues in a Covariance Matrix by Bulk Eigenvalue Matching Analysis
基于谱主体特征值匹配的协方差尖峰特征值数量估计AI 解读 ↓
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The spiked covariance model has gained increasing popularity in high-dimensional data analysis. A fundamental problem is determination of the number of spiked eigenvalues, K. For estimation of K, most attention has focused on the use of top eigenvalues of sample covariance matrix, and there is little investigation into proper ways of using bulk eigenvalues to estimate K. We propose a principled approach to incorporating bulk eigenvalues in the estimation of K. Our method imposes a working model on the residual covariance matrix, which is assumed to be a diagonal matrix whose entries are drawn from a gamma distribution. Under this model, the bulk eigenvalues are asymptotically close to the quantiles of a fixed parametric distribution. This motivates us to propose a two-step method: the first step uses bulk eigenvalues to estimate parameters of this distribution, and the second step leverages these parameters to assist the estimation of K. The resulting estimator K̂ aggregates information in a large number of bulk eigenvalues. We show the consistency of K̂ under a standard spiked covariance model. We also propose a confidence interval estimate for K. Our extensive simulation studies show that the proposed method is robust and outperforms the existing methods in a range of scenarios. We apply the proposed method to analysis of a lung cancer microarray dataset and the 1000 Genomes dataset.
The conditional average treatment effect (CATE) is frequently estimated in clinical studies to refute a homogeneous treatment effect hypothesis. Under this regime, all patients making up the population experience identical benefit from a given treatment relative to a comparator. Uncovering heterogeneous treatment effects through inference about the CATE, however, requires that covariates truly modifying the treatment effect be reliably collected at baseline. CATE-based…
异质性高维分位数回归的全局推断
Quantile regression has received considerable attention in high dimensional methodology due to its robustness and ability to accommodate heteroskedasticity. Despite this attention, current inferential methods for high dimensional quantile regression have significant limitations---only testing significance, testing at a single quantile at a time, or assuming homoskedasticity. To generalize the inferences that can be drawn in high dimensional quantile regression, we introduce…
超越来源域整体迁移:高维分位数回归的样本级学习
This paper studies transfer learning for high-dimensional quantile regression with limited target samples and heterogeneous source domains. We propose a sample-level transfer learning method (SL-TL) that combines sample selection and importance weighting. Unlike existing source-level approaches that include or exclude entire source domains, SL-TL identifies transferable samples within each source domain and incorporates them through adaptive importance weights. The proposed…
极端分位数回归加权最大似然估计量的存在性与一致性
Estimating extreme conditional quantiles faces two major challenges: understanding complex nonlinear relationships between variables and accurately extrapolating into the tails of the distribution, where data are sparse. To address both issues, we introduce a novel approach that combines the theoretical framework of block maxima with the predictive power of generalized random forests. The conditional distribution of maxima is modeled by a generalized extreme value (GEV)…
非正则情形下的交叉拟合:基于局部性的正态性与推断
Cross-fitting is routine in much of applied research. While conventional confidence intervals that ignore cross-fold dependence are asymptotically valid in several settings, they undercover in many applications that share a common form of nonregularity: from the classic cross-validation problem of testing whether a fitted model outperforms another, to testing for heterogeneous treatment effects with machine learning, to estimating the value of a potentially non-unique…
贝叶斯神经网络辅助多处理混合治愈生存模型:儿科肿瘤应用
Estimating covariate-conditional treatment effects in multi-arm oncology studies is complicated when treatment arms have common distributional features and a non-negligible fraction of patients achieve long-term remission. We propose a joint mixture cure model with covariate-dependent mixtures of log-normal kernels with treatment-specific inclusions. Both linear and neural-network-assisted non-linear covariate links are proposed. Specifically, the susceptible survival…