每日简报

mnorm：计算与求导条件多元正态密度和概率的 R 包AI 解读

We introduce the mnorm package, which allows one to calculate conditional multivariate normal densities and probabilities and to differentiate them with respect to various parameters including covariances and integration limits. The package also supports parallel (multi-core) computing, handles non-normal marginals via the Gaussian copula, and provides fast routines for the calculation of bivariate and trivariate normal probabilities. The package is of special interest for…

B-CALM：协变量不匹配下以随机试验为锚的偏差受限贝叶斯信息借用AI 解读

Randomized controlled trials (RCTs) identify treatment effects in the randomized trial population but are often too small for reliable heterogeneity estimation; observational studies (OS) are larger but confounded and measured on only partially overlapping covariates. We develop Bayesian Calibrated ALignment under covariate Mismatch (B-CALM), a Bayesian borrowing method for RCT-defined conditional average treatment effect (CATE) estimation. B-CALM maps source-specific…

多元高斯数据异常检测的渐近精确阈值及时间序列应用AI 解读

In this paper, we propose a new thresholding technique for detecting anomalies in multivariate normal random samples, under the assumption that anomalous observations are sparse and differ from the rest of the data in their mean. The mean vector of the non-anomalous data is assumed to be zero, while the covariance matrix is unknown. We derive conditions on the mean shift of the anomalous observations, as well as on the covariance matrix and its estimator, under which the…

种族的哪一种效应？不固定其他特征的因果推断AI 解读

Empirical studies of racial discrimination vary race while holding nonracial traits fixed, a design the literature defends as what credible inference requires. This defense bundles two claims: which effect of race a study should target, and whether its design can recover that effect. I separate them. The same randomization that secures credible estimation and inference recovers a family of race estimands, from the all-else-equal effect to a within-race effect that lets…

Mendelian randomization (MR) infers causal effects of exposures on outcomes using genetic variants as instrumental variables, but existing methods remain vulnerable to bias and loss of power when instruments are invalid. We hypothesize that closely related outcome traits share a large overlap in their valid instruments for a given exposure, so that borrowing instruments across such traits can yield more robust MR inference. To operationalize this, we introduce a novel…

用于个体化治疗规则的结局加权学习神经网络AI 解读

Individualized treatment rules (ITRs) formalize precision medicine by assigning treatments according to patient covariates, with the goal of maximizing expected clinical outcomes. Such rules are especially important when treatment effects vary across patients, as in chronic diseases where demographic, clinical, genetic, imaging, or biomarker information may modify the relative benefits of available therapies. Individualized treatment rules (ITRs) formalize precision medicine…

条件矩约束下核最小距离估计与检验的统一框架AI 解读

We propose a unified Kernel Minimum Distance (KMD) framework for estimating and testing models defined by conditional moment restrictions. By embedding conditional moments into a Reproducing Kernel Hilbert Space (RKHS), we construct a closed-form $V$-statistic objective function that quantifies the distance from the restrictions. We establish the $\sqrt{n}$-consistency and asymptotic normality of the associated minimum distance estimator. Within this framework, the minimized…

采用斜对称归一化的广义重参数化变分贝叶斯AI 解读

Bayesian hierarchical models with high-dimensional latent structure require scalable posterior approximations that preserve key dependencies while remaining computationally tractable. Mean-field variational inference (MFVI) is efficient, but can be unreliable when local variables are strongly correlated or tightly coupled to global variables. We propose KNorm-RVB, a generalized reparametrized variational Bayes framework for latent Gaussian and latent non-Gaussian models with…

函数型数据的自适应岭正则 Hotelling 变点检验AI 解读

We propose a unified ridge-regularized Hotelling framework for detecting and locating mean changes in functional time series. A growing basis expansion converts the functional observations into high-dimensional score vectors. Their long-run covariance is estimated by an edge-corrected difference-based procedure. Ridge regularization stabilizes inference under spectral decay. An explicit local-power formula shows that the power-maximizing ridge depends on the unknown spectral…

调查时间序列的贝叶斯季节调整AI 解读

Seasonal adjustment procedures used by national statistical offices -- X-11 and X-12-ARIMA -- treat each survey estimate as an exact observation, discarding the accompanying standard errors that survey methodologists routinely compute. This paper closes that gap by embedding time-varying sampling error variances into a Basic Structural Model (BSM), extending a recently proposed Dynamic Mini-Max (DMM) Bayesian framework for survey estimation. Via the Harvey-Todd equivalence,…

Normality pre-tests on reduced-form innovations cannot detect whether two or more underlying structural shocks are Gaussian, and hence cannot detect a failure of identification in non-Gaussian SVARs. We propose a bootstrap-based approach that reveals such a failure. Under the null of valid identification and certain regularity conditions, the conditional bootstrap distribution of the maximum likelihood estimator of the impact matrix is asymptotically normal, so the…

因果异质性的分辨率AI 解读

Causal subgroup analyses often report a small number of groups summarizing treatment effect heterogeneity, as if that number were a well-defined estimand. Outside genuinely latent class populations, however, a ``true'' subgroup count is model dependent rather than a population functional. We replace it with a new population estimand, the resolution profile, a functional of the causal feature law giving the fewest groups explaining a prescribed fraction of causal…

基于方差的治疗效应异质性检验AI 解读

This paper proposes a robust nonparametric hypothesis test for the existence of heterogeneous treatment effects. We focus on the variance of the Conditional Average Treatment Effect (CATE) as a natural omnibus parameter, where a non-zero variance implies the presence of relevant heterogeneity. Standard inference for this parameter faces a fundamental theoretical challenge. On one hand, evaluating variance components on the same sample leads to null degeneracy, where the…

用于离散选择估计的表格基础模型AI 解读

Tabular foundation models (TFMs) generate predictions on structured data via in-context learning, without task-specific estimation. We ask whether TFMs can be effectively applied to discrete choice, a central demand estimation framework in marketing and operations, and find that directly applying TFMs yields limited performance. The gap is structural: TFMs assume row-independent observations, whereas discrete choice is inherently set-valued and subject to persistent consumer…

非平稳时间序列局部化部分和的函数型中心极限定理AI 解读

A localized functional central limit theorem is established for kernel-weighted partial sum processes of piecewise locally stationary time series under geometric decay of the physical dependence measure. The localized process is shown to converge weakly to a centered Gaussian random distribution in $D'(0,1)$, and the limit extends naturally to an isonormal Gaussian process on $L^2([0,1])$. Weak convergence is further derived for processes indexed by totally bounded subsets…

网络元回归模型假设影响的模拟评估AI 解读

Network meta-regression (NMR) extends network meta-analysis (NMA) by synthesizing evidence on multiple treatments while adjusting for potential effect modifiers. By accounting for effect modification, NMR can reduce between-study heterogeneity and improve the validity of relative treatment effects, providing insight regarding characteristics impacting treatment performance. However, choosing between available NMR models is complex, as each model addresses a similar, but…

时变混杂下平均处理效应估计的缺失数据方法比较AI 解读

Missing data and confounding are common in real-world statistical applications, yet few studies have examined how imputation methods perform under time-varying confounding in binary variables, or how missingness mechanism, missing rate, missingness location and sample size jointly affect performance and the underlying identifiability conditions. We generated synthetic data and conducted a simulation study comparing missing data methods across scenarios varying these factors.…

ATLAS：异质环境中不变且可迁移潜在因子的识别AI 解读

This paper considers a multi-environment factor model in which high-dimensional covariates are collected from heterogeneous environments, with auxiliary labels available in a subset of these environments. The joint distribution of the covariates may vary across environments, whereas the latent structure is decomposed into invariant factors with shared loadings and heterogeneous factors with environment-specific loadings. Such a model is motivated by transfer learning and…

向量检索作为最近邻匹配：因果推断中的 RAG 政策学习AI 解读

We propose one-step and two-step methods for policy learning with retrieval-augmented generation (RAG). We formulate RAG-based action selection under the potential outcome framework. In the two-step method, vector search retrieves action-specific neighboring evidence in an embedding space, the generator estimates conditional expected outcomes or their contrasts, and a plug-in rule selects an action. This formulation connects action-specific vector search with…

不规则时间序列的因果发现AI 解读

Causal discovery methods have shown strong performance in temporal systems, but they typically rely on regular and discrete lag structures, limiting their applicability to regularly sampled data. However, many real-world tasks require dealing with irregularly sampled streams of events, such as sensor streams, healthcare data, and financial transactions. In this work, we propose an extension of PCMCI+, a state-of-the-art method for causal discovery on regular multivariate…

SPYCE：结果依赖删失下早期亨廷顿病终点的双重稳健估计AI 解读

Clinical trials for neurodegenerative diseases must identify sensitive endpoints -- outcomes that change rapidly enough to detect treatment effects. In Huntington disease, this requires measuring how outcomes change as participants approach Stage 1. Yet many participants exit studies before reaching this stage, making their time to Stage 1 right-censored. Estimating how outcomes change requires models for both time to Stage 1 and time to study exit. When participants with…

两样本孟德尔随机化的自适应惩罚与自助平滑推断AI 解读

Two-sample Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate causal effects from observational data using summary association statistics. However, horizontal pleiotropy can invalidate standard MR estimators and lead to biased causal inference. Pleiotropy-robust methods have been proposed to address this issue, including regularization-based approaches such as MR-Lasso. However, MR-Lasso may fail to identify invalid instruments…

基于持久拉普拉斯特征的在线变点检测AI 解读

Online change-point detection in high-dimensional nonlinear time series faces two challenges. The underlying distributions are difficult to model, and state changes are difficult to characterize. We propose persistent Laplacian cumulative sum (PL-CUSUM) to address these challenges. PL-CUSUM maps delay-embedded sliding windows to point clouds. It extracts persistent Betti vectors and the positive spectra of persistent Laplacians from the same Vietoris-Rips filtration. A…

因果治愈模型的贝叶斯方法AI 解读

Time-to-event data often include individuals who will never experience the failure event, and are therefore considered cured. In such settings, frequently encountered in clinical research, a substantial proportion of patients may remain event-free throughout the observation period, leading to the appearance of a survival plateau that is commonly interpreted as evidence of a cured fraction. Analysing such data requires inference on the cure fraction and on the survival…