Tree-aggregated compositional regression under measurement error
测量误差下的树聚合组成数据回归
Compositional covariates in microbiome studies are often measured with error and organized by a biological hierarchy. Tree aggregation can improve multiresolution interpretation, but it also combines leaf-level errors into correlated contamination whose scale varies across the hierarchy. Existing tree aggregation and compositional measurement-error correction do not combine directly in redundant tree coordinates because a generic positive semidefinite projection can make the…