每日简报

电子健康记录研究中处理未测混杂的代理变量方法AI 解读

Electronic health records (EHR) are widely used to study clinical decisions, yet unmeasured confounding remains a persistent challenge. Proxy variables offer a potential solution. In EHR data, clinicians already record many such measurements (e.g., vitals), each revealing something about a patient's underlying health. Despite this, proxy-based methods are rarely used in practice. We introduce a new way to use proxies to adjust for unmeasured confounding. Our approach uses a…

高效且易用的离散选择实验：R 包 DCEtoolAI 解读

Discrete Choice Experiments (DCEs) are widely used to elicit preferences for products or services by analyzing choices among alternatives described by their attributes. The quality of the insights obtained from a DCE heavily depends on the properties of its experimental design. While early DCEs often relied on linear criteria such as orthogonality, these approaches were later found to be inappropriate for discrete choice models, which are inherently non-linear. As a result,…

通过样本分割评估 A/B 测试方法：理论与实践AI 解读

We develop a theoretical framework for sample splitting in A/B testing environments, where data for each test are partitioned into two splits to measure methodological performance when the true impacts of tests are unobserved. We show that sample-split estimators are generally biased for full-sample performance but consistently estimate sample-split analogues of it. We derive their asymptotic distributions, construct valid confidence intervals, and characterize the…

结合实验前与实验中数据降低处理效应估计方差AI 解读

Online controlled experiments (A/B testing) are fundamental to data-driven decision-making in many companies. Improving the sensitivity of these experiments under fixed sample size constraints requires reducing the variance of the average treatment effect (ATE) estimator. Existing variance reduction techniques such as CUPED and CUPAC use pre-experiment data, but their effectiveness depends on how predictive those data are for outcomes measured during the experiment.…

用双重机器学习估计多种处理及其交互效应AI 解读

Causal inference literature has extensively focused on binary treatments, with relatively fewer methods developed for multi-valued treatments. In particular, methods for multiple simultaneously assigned treatments remain understudied despite their practical importance. This paper introduces two settings: (1) estimating the effects of multiple treatments of different types (binary, categorical, and continuous) and the effects of treatment interactions, and (2) estimating the…

利用数字健康数据评估序贯效应的累积边际均值模型AI 解读

Mobile health (mHealth) leverages digital technologies, such as mobile phones, to capture objective, frequent, and real-world digital phenotypes from individuals, enabling the delivery of tailored interventions to accommodate substantial between-subject and temporal heterogeneity. However, evaluating heterogeneous treatment effects (HTEs) using digital phenotype data is challenging because treatments are delivered dynamically over time and may generate carryover effects that…

利用既有研究学习处理效应：贝叶斯模型平均方法AI 解读

We establish concentration rates for estimation of treatment effects in experiments that incorporate prior sources of information -- such as past pilots, related studies, or expert assessments -- whose external validity is uncertain. Each source is modeled as a Gaussian prior with its own mean and precision, and sources are combined using Bayesian model averaging (BMA), allowing data from the new experiment to update posterior weights. To capture empirically relevant…

等误差方差结构方程模型的一致贝叶斯因果发现AI 解读

We consider the problem of recovering the true causal structure among a set of variables, generated by a linear acyclic structural equation model (SEM) with the error terms being independent, not necessarily Gaussian, and having equal variances. It is well-known that the true underlying directed acyclic graph (DAG) encoding the causal structure is uniquely identifiable under this assumption. Interestingly, in this setting, it further holds that the sum of minimum expected…

干扰、同质性与稳健性权衡下的最优实验设计AI 解读

To minimize the mean squared error (MSE) in global average treatment effect (GATE) estimation under network interference, a popular approach is to use a cluster-randomized design. However, in the presence of homophily, which is common in social networks, cluster randomization can instead increase the MSE. We develop a novel potential outcomes model that accounts for interference, homophily, and heterogeneous variation. In this setting, we establish a framework for optimizing…

工具变量回归的改进推断：结合低维与多工具变量检验AI 解读

Empirical instrumental variables (IV) studies often report separate results based on low-dimensional instruments and many base instruments. This paper proposes a combination test that integrates these commonly reported statistics. The test linearly combines a cluster-robust Wald statistic based on low-dimensional IVs with leave-one-cluster-out Lagrangian Multiplier (LM) and Anderson-Rubin (AR) statistics constructed from many IVs. We establish joint asymptotic normality and…

含期中分析的平台试验如何纳入非同期对照AI 解读

The analysis of platform trials can be enhanced by utilizing non-concurrent controls. Since including this data might also introduce bias in the treatment effect estimators if time trends are present, methods for incorporating non-concurrent controls adjusting for time have been proposed. However, so far their behavior has not been systematically investigated in platform trials that include interim analyses. To evaluate the impact of an interim analysis in trials utilizing…

处理后混杂下集群随机试验因果机制的贝叶斯非参数识别与估计AI 解读

Causal mediation analysis in cluster-randomized trials (CRTs) is essential for explaining how cluster-level interventions affect individual outcomes, yet it is complicated by interference, post-treatment confounding, and hierarchical covariate adjustment. We develop a Bayesian nonparametric framework that simultaneously accommodates interference and a post-treatment confounder that precedes the mediator. Identification is achieved through a multivariate Gaussian copula that…

连续处理后变量主层分析的贝叶斯非参数方法AI 解读

Principal stratification provides a causal inference framework for investigating treatment effects in the presence of a post-treatment variable. Principal strata play a key role in characterizing the treatment effect by identifying groups of units with the same or similar values for the potential post-treatment variable at all treatment levels. The literature has focused mainly on binary post-treatment variables. Few papers considered continuous post-treatment variables. In…

双边市场实验中的随机化推断AI 解读

Randomized experiments are increasingly employed in two-sided markets, such as buyer--seller platforms, to evaluate the effects of marketplace interventions. These experiments must reflect the underlying two-sided market structure in their design and can therefore be challenging to analyze. In this paper, we develop a randomization inference framework for outcomes from two-sided experiments, with a focus on testing and inference for two-sided spillover effects. Our approach…

部分观测数据推断的校准框架AI 解读

Missing data is an universal problem in statistics. We develop a unified framework for estimating parameters defined by general estimating equations under a missing-at-random (MAR) mechanism, based on generalized entropy calibration weighting. We construct weights by minimizing a convex entropy subject to (i) balancing constraints on a data-adaptive calibration function, estimated using flexible machine-learning predictors with cross-fitting, and (ii) a debiasing constraint…

终末事件与仅在事件未发生时存在的评分之联合评估框架AI 解读

Analysis of data from randomized controlled trials in vulnerable populations requires special attention when assessing treatment effect by a score measuring, e.g., disease stage or activity together with onset of prevalent terminal events. In reality, it is impossible to disentangle a disease score from the terminal event, since the score is not clinically meaningful after this event. In this work, we propose to assess treatment interventions simultaneously on the terminal…

跨世界假设与个体处理效应预测区间的细化AI 解读

While average treatment effects (ATE) and conditional average treatment effects (CATE) provide valuable population- and subgroup-level summaries, they fail to capture uncertainty at the individual level. For high-stakes decision-making, individual treatment effect (ITE) estimates must be accompanied by valid prediction intervals that reflect heterogeneity and unit-specific uncertainty. However, the fundamental unidentifiability of ITEs limits the ability to derive precise…

结合 BART 与主分层估计避孕使用对就业的影响：尼日利亚与塞内加尔AI 解读

There is interest in learning about the causal effects of modern contraceptive use on empowerment outcomes. Data on this question often come from family planning (FP) programs that increase access to FP and facilitate contraceptive use among some women, rather than directly assigning use. Women whose contraceptive behavior changes because of these programs ("compliers") may differ from target populations in ways that alter the consequences of contraceptive use for…

结合 BART 与主分层估计中间变量效应：撒哈拉以南非洲计划生育与就业AI 解读

There is interest in learning about the causal effect of family planning (FP) on empowerment related outcomes. Experimental data related to this question are available from trials in which FP programs increase access to FP. While program assignment is unconfounded, FP uptake and subsequent empowerment may share common causes. We use principal stratification to estimate the causal effect of an intermediate FP outcome on a primary outcome of interest, among women affected by a…

利用辅助数据集中的工具变量识别因果效应AI 解读

Instrumental variable approaches have gained popularity for estimating causal effects in the presence of unmeasured confounders. However, the availability of instrumental variables in the primary dataset is often challenged due to stringent and untestable assumptions. This paper presents a novel method to identify and estimate causal effects by utilizing instrumental variables from the auxiliary dataset, incorporating a structural equation model, even in scenarios with…

通过 Softmax 平滑推断最优政策价值及其他非正则泛函AI 解读

Constructing confidence intervals for the value of an (unknown) optimal treatment policy is a fundamental problem in causal inference. Insight into the optimal policy value can guide the development of reward-maximizing, individualized treatment regimes. However, because the functional that defines the optimal value is non-differentiable, standard semi-parametric approaches for performing inference fail to be directly applicable. Many existing works circumvent…

自适应实验的设计稳定性及其对处理效应估计的影响AI 解读

We study the problem of estimating the average treatment effect (ATE) under sequentially adaptive treatment assignment mechanisms. In contrast to classical completely randomized designs, we consider a setting in which the probability of assigning treatment to each experimental unit may depend on prior assignments and observed outcomes. Within the potential outcomes framework, we propose and analyze two natural estimators for the ATE: the inverse propensity weighted (IPW)…

动态潜在类别结构方程模型：密集纵向数据建模实操教程AI 解读

In this tutorial, we provide a hands-on guideline on how to implement complex Dynamic Latent Class Structural Equation Models (DLCSEM) in the Bayesian software JAGS. We provide building blocks starting with simple Confirmatory Factor and Time Series analysis, and then extend these blocks to Multilevel Models and Dynamic Structural Equation Models (DSEM). Subsequently, we introduce Hidden Markov Switching Models (HMSM) and demonstrate their integration with DSEM to yield…

用贝叶斯层级可调随机分区识别自适应富集试验中的治疗效应异质性AI 解读

Treatment effect heterogeneity refers to the systematic variation in treatment effects across subgroups. There is an increasing need for clinical trials that aim to investigate treatment effect heterogeneity and estimate subgroup-specific responses. While several statistical methods have been proposed to address this problem, existing partitioning-based methods often depend on auxiliary analysis, overlook model uncertainty, or impose inflexible borrowing strength. We propose…