每日简报

超越平均处理效应：A/B 测试的多准则设计AI 解读

In the era of large-scale AI deployment and high-stakes clinical trials, adaptive experimentation faces a ``trilemma'' of conflicting objectives: minimizing cumulative regret (welfare loss during the experiment), maximizing the estimation accuracy of heterogeneous treatment effects (CATE), and ensuring differential privacy (DP) for participants. Existing literature typically optimizes these metrics in isolation or under restrictive parametric assumptions. In this work, we…

工具变量回归的差分隐私两阶段梯度下降AI 解读

We study instrumental variable regression (IVaR) under differential privacy constraints. Classical IVaR methods (like two-stage least squares regression) rely on solving moment equations that directly use sensitive covariates and instruments, creating significant risks of privacy leakage and posing challenges in designing algorithms that are both statistically efficient and differentially private. We propose a noisy two-stage gradient descent algorithm that ensures $ρ$-zero-c…

事件发生时间结局的超级学习器：实践教程AI 解读

Estimating risks or survival probabilities conditional on individual characteristics based on censored time-to-event data is a commonly faced task. This may be for the purpose of developing a prediction model or may be part of a wider estimation procedure, such as in causal inference. A challenge is that it is impossible to know at the outset which of a set of candidate models will provide the best risk estimates. The super learner is a powerful approach for finding the best…

利用干预数据刻画并学习含潜在混杂与处理后选择的因果图AI 解读

Interventional causal discovery seeks to identify causal relations by leveraging distributional changes introduced by interventions, even in the presence of latent confounders. Beyond the spurious dependencies induced by latent confounders, we highlight a common yet often overlooked challenge in the problem due to post-treatment selection, in which samples are selectively included in datasets after interventions. This fundamental challenge widely exists in biological…

死亡截断及其他中间事件下纵向研究治疗效应的稳健评估AI 解读

Intercurrent events, such as treatment switching, rescue medication, dropout, or truncation by death, frequently complicate intention-to-treat analyses in randomized clinical trials. Existing causal inference frameworks typically target hypothetical or principal stratum estimands (e.g., survivor average causal effects), which rely on unverifiable assumptions and can be sensitive to unmeasured confounders or positivity violations. We propose a novel approach that mitigates…

灭绝风险的置信区间：有限数据下种群存续分析的验证AI 解读

Quantitative assessment of extinction risk requires confidence intervals (CIs) that remain informative with limited data. Their usefulness has long been debated because short observation spans can make uncertainty so large that population viability analysis appears impractical. I derive new CIs for extinction probability under the drift-Wiener process, a canonical model of extinction dynamics, by introducing transformed parameters $w$ and $z$ whose maximum-likelihood…

高效且易用的离散选择实验：R 包 DCEtoolAI 解读

Discrete Choice Experiments (DCEs) are widely used to elicit preferences for products or services by analyzing choices among alternatives described by their attributes. The quality of the insights obtained from a DCE heavily depends on the properties of its experimental design. While early DCEs often relied on linear criteria such as orthogonality, these approaches were later found to be inappropriate for discrete choice models, which are inherently non-linear. As a result,…

利用数字健康数据评估序贯效应的累积边际均值模型AI 解读

Mobile health (mHealth) leverages digital technologies, such as mobile phones, to capture objective, frequent, and real-world digital phenotypes from individuals, enabling the delivery of tailored interventions to accommodate substantial between-subject and temporal heterogeneity. However, evaluating heterogeneous treatment effects (HTEs) using digital phenotype data is challenging because treatments are delivered dynamically over time and may generate carryover effects that…

等误差方差结构方程模型的一致贝叶斯因果发现AI 解读

We consider the problem of recovering the true causal structure among a set of variables, generated by a linear acyclic structural equation model (SEM) with the error terms being independent, not necessarily Gaussian, and having equal variances. It is well-known that the true underlying directed acyclic graph (DAG) encoding the causal structure is uniquely identifiable under this assumption. Interestingly, in this setting, it further holds that the sum of minimum expected…

含期中分析的平台试验如何纳入非同期对照AI 解读

The analysis of platform trials can be enhanced by utilizing non-concurrent controls. Since including this data might also introduce bias in the treatment effect estimators if time trends are present, methods for incorporating non-concurrent controls adjusting for time have been proposed. However, so far their behavior has not been systematically investigated in platform trials that include interim analyses. To evaluate the impact of an interim analysis in trials utilizing…

半参数模型中以优化为中心的反馈切断方法AI 解读

Complex statistical models are often built by combining multiple submodels, called modules. Here we consider modular inference where the modules contain both parametric and nonparametric components. In such cases, standard Bayesian inference can be highly sensitive to misspecification in any module, and influential prior specifications for the nonparametric components can compromise inference for the parametric components, and vice versa. We propose a novel…

因果推断中的外推正则化AI 解读

Many common estimators in machine learning and causal inference are linear smoothers, where the prediction is a weighted average of the training outcomes. Some estimators, such as ordinary least squares and kernel ridge regression, allow for arbitrarily negative weights, which improve feature imbalance but often at the cost of increased dependence on parametric modeling assumptions and higher variance. By contrast, estimators like importance weighting and random forests…

用于智能体流行病模型快速校准的机器学习方法AI 解读

Agent-based models (ABMs) are widely used to study infectious disease dynamics, but their calibration is often computationally intensive, limiting their applicability in time-sensitive public health settings. We propose DeepIMC (Deep Inverse Mapping Calibration), a machine learning-based calibration framework that directly learns the inverse mapping from epidemic time series to epidemiological parameters. DeepIMC trains a bidirectional Long Short-Term Memory (BiLSTM) neural…

通过基于模拟的推断改进因果评估的生成方法AI 解读

Generating synthetic datasets that accurately reflect real-world observational data is critical for evaluating causal estimators, but it remains a challenging task. Existing generative methods offer a solution by producing synthetic datasets anchored in the observed data (source data) while allowing variation in key parameters such as the treatment effect and amount of confounding bias. However, it is often unclear which generative methods to use and which values of…

低阶结局交互干扰下的协变量调整与处理效应估计AI 解读

In randomized experiments, covariates are often used to reduce variance and improve the precision of treatment effect estimates. However, in many real-world settings, interference between units, where one unit's treatment affects another's outcome, complicates causal inference. This raises a key question: how can covariates be effectively used in the presence of interference? Addressing this challenge is nontrivial, as direct covariate adjustment, such as through regression,…

尾部不确定性下部分识别处理效应的混合置信带及企业性别多样性应用AI 解读

Manski's nonparametric bounds partially identify the average treatment effects (ATEs) under minimal assumptions, yielding an interval-valued estimand with endpoints that depend on the outcome support - typically treated as known or fixed. In many empirical settings, however, credible bounds on the outcome support are often unavailable and outcomes may be heavy-tailed, so common empirical implementations that rely on ad-hoc truncation or observed extrema can compromise…

利用潜类别选择模型对态度与行为关系进行后验推断AI 解读

The link between attitudes and behaviour has been a key topic in choice modelling for two decades, with the widespread application of ever more complex hybrid choice models. This paper proposes a pragmatic and computationally tractable alternative framework for empirically examining the relationship between attitudes and behaviours using latent class choice models (LCCMs). Rather than embedding attitudinal constructs within the structural model, as in hybrid choice…

局部平稳时间序列中基于 CUSUM 的自标准化变点检测AI 解读

A new bivariate partial sum process for locally stationary time series is introduced and its weak convergence to a Brownian sheet is established. This construction enables the development of a novel self-normalized CUSUM test statistic for detecting changes in the mean of a locally stationary time series. For stationary data, self-normalization relies on the factorization of a constant long-run variance and a stochastic factor. In this case, the CUSUM statistic can be…

单侧不依从聚类随机试验中的潜在依从性贝叶斯建模AI 解读

In pragmatic cluster randomized controlled trials (PCRCTs), healthcare providers are randomized while both providers and patients may deviate from the assigned intervention. In many PCRCTs, cluster-level implementation is measured using multiple continuous metrics, while individual compliance is recorded as a binary indicator. Standard complier average causal effect (CACE) estimands focus on individual-level compliance and do not account for heterogeneity in implementation…

仅用分类与少量回归实现逆强化学习AI 解读

Inverse reinforcement learning (IRL) aims to infer rewards from observed behavior, but rewards are not identified from the policy alone: many reward--value pairs can rationalize the same actions. Meaningful reward recovery therefore requires a normalization, yet existing normalized IRL methods often rely on anchor-action restrictions or specialized neural architectures. We study reward recovery in the maximum-entropy, or Gumbel-shock, model under a broad class of statewise…

多维构念与调节线性及非线性因子分析AI 解读

Multidimensional factor models with moderations on all model parameters have so far been limited to single-factor and two-factor models. This does not align well with existing psychological measures, which are commonly intended to assess 3-5 dimensions of a latent construct. In this paper, I introduce a multidimensional MNLFA model that permits the moderation of item intercepts, loadings, residual variances, factor means, variances, and correlations across three or more…

诊断性预期的识别：来自 DSGE 模型的计量分析AI 解读

This paper shows that diagnostic expectations (DE) and rational expectations (RE) are not observationally equivalent in dynamic stochastic general equilibrium (DSGE) models. Using the frequency-domain framework of Qu and Tkachenko (2012, 2017), I show that no RE parameterization yields the DE-implied autocovariance structure of the macroeconomic observables considered in either small- or medium-scale DSGE models, even after structural frictions and shock processes are…

结合专家先验的延迟治疗效应自适应临床试验设计AI 解读

Clinical trials with time-to-event endpoints, such as overall survival (OS) or progression-free survival (PFS), are fundamental for evaluating new treatments, particularly in immuno-oncology. However, modern therapies, such as immunotherapies and targeted treatments, often exhibit delayed effects that challenge traditional trial designs. These delayed effects violate the proportional hazards assumption, which underpins standard statistical methods like the Cox proportional…

用于金砖四国长记忆汇率预测的神经 ARFIMA 模型AI 解读

Exchange rate forecasting remains a challenging problem, particularly for emerging economies, where the observed time series exhibit pronounced long-memory dependence, nonlinear dynamics, and sensitivity to macro-financial drivers. Classical models such as ARFIMA capture long-range persistence but fail to adequately represent nonlinear relationships, while modern machine learning approaches often neglect the underlying long-memory structure in macroeconomic series. To…