每日简报

因果发现后的因果效应选择后推断AI 解读

Algorithms for constraint-based causal discovery select graphical causal models among a space of possible candidates (e.g., all directed acyclic graphs) by executing a sequence of conditional independence tests. These may be used to inform the estimation of causal effects (e.g., average treatment effects) when there is uncertainty about which covariates ought to be adjusted for, or which variables act as confounders versus mediators. However, naively using the data twice,…

整群随机试验中的模型稳健标准化AI 解读

In cluster-randomized trials, generalized linear mixed models and generalized estimating equations have conventionally been the default analytic methods for estimating the average treatment effect as routine practice. However, recent studies have demonstrated that their treatment effect coefficient estimators may correspond to ambiguous estimands when the models are misspecified or when there exists informative cluster sizes. In this article, we present a unified approach…

超越单调性假设的半参数主分层分析AI 解读

Intercurrent events, common in clinical trials and observational studies, affect the existence or interpretation of final outcomes. Principal stratification addresses this challenge by defining local average treatment effect estimands within subpopulations, but often relies on restrictive assumptions such as monotonicity and counterfactual intermediate independence. To overcome these limitations, we propose a semiparametric framework for principal stratification analysis…

细化双重差分研究中的无预期效应概念AI 解读

We address an ambiguity in identification strategies using difference-in-differences, which are widely applied in empirical research, particularly in economics. The assumption commonly referred to as the "no-anticipation assumption" states that treatment has no effect on outcomes before its implementation. However, because standard causal models rely on a temporal structure in which causes precede effects, such an assumption seems to be inherently satisfied. This raises the…

稳定隐性混杂与二元结果的准工具变量方法AI 解读

Instrumental variable (IV) methods are central to causal inference from observational data, particularly when a randomized experiment is not feasible. However, of the three conventional core IV identification conditions, only one, IV relevance, is empirically verifiable; often one or both of the other conditions, exclusion restriction and IV independence from unmeasured confounders, are unmet in real-world applications. These challenges are compounded when the outcome is…

协变量平衡与平均处理效应加权、双重稳健估计量的等价性AI 解读

How should researchers adjust for covariates? We show that if the propensity score is estimated using a specific covariate balancing approach, inverse probability weighting (IPW), augmented inverse probability weighting (AIPW), and inverse probability weighted regression adjustment (IPWRA) estimators are numerically equivalent for the average treatment effect (ATE), and likewise for the average treatment effect on the treated (ATT). The resulting weights are inherently…

马尔可夫结构因果模型的规范表示：反事实推理框架AI 解读

Counterfactual reasoning aims at answering contrary-to-fact questions like ``Would have Alice recovered had she taken aspirin?'' and corresponds to the most fine-grained layer of causation. Critically, while many counterfactual statements cannot be falsified-even by randomized experiments-they underpin fundamental concepts like individual-wise fairness. Therefore, providing models to formalize and implement counterfactual beliefs remains a fundamental scientific problem. In…

不必完全排除：使用半工具变量开展因果推断AI 解读

This paper proposes semi-instrumental variables (semi-IVs) as an alternative to instrumental variables (IVs) to identify the causal effect of a binary (or discrete) endogenous treatment. A semi-IV is a less restrictive form of instrument: it affects the selection into treatment but is excluded only from one, not necessarily both, potential outcomes. Having two continuously distributed semi-IVs, one excluded from the potential outcome under treatment and the other from the…

存在样本选择的配对关系回归AI 解读

This paper addresses the sample selection problem in panel dyadic regression analysis. Dyadic data often include many zeros in the main outcomes due to the underlying network formation process. This not only contaminates popular estimators used in practice but also complicates the inference due to the dyadic dependence structure. We extend Kyriazidou (1997)'s approach to dyadic data and characterize the asymptotic distribution of our proposed estimator. The convergence rates…

反事实余循环：稳健且一致的反事实传输框架AI 解读

Estimating joint distributions (a.k.a. couplings) over counterfactual outcomes is central to personalized decision-making and treatment risk assessment. Two emergent frameworks with identifiability guarantees are: (i) bijective structural causal models (SCMs), which are flexible but brittle to mis-specified latent noise; and (ii) optimal-transport (OT) methods, which avoid latent noise assumptions but can produce incoherent counterfactual transports which fail to identify…

利用观测数据评价处理获益预测器：识别与混杂偏差AI 解读

A treatment benefit predictor (TBP) is a function that maps patient characteristics to an estimate of the treatment benefit for that patient. Such predictors support optimizing individualized treatment decisions, which are central to precision medicine. However, evaluating the predictive performance of a TBP is challenging, as this often must be conducted in a sample where treatment assignment is not random. After briefly reviewing several metrics for evaluating TBPs, we…

存在终末事件时复发事件期望次数的因果推断AI 解读

While recurrent event analyses have been extensively studied, limited attention has been given to causal inference within the framework of recurrent event analysis. We develop a multiply robust estimation framework for causal inference in recurrent event data with a terminal failure event. We define our estimand as the vector comprising both the expected number of recurrent events and the failure survival function evaluated along a sequence of landmark times. We show that…

零膨胀单细胞 RNA 测序数据的共同中介统计框架AI 解读

Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of cellular heterogeneity, enabling detailed molecular profiling at the individual cell level. However, integrating high-dimensional single-cell data into causal mediation analysis remains challenging due to zero inflation and complex mediator structures. We propose a novel mediation framework leveraging zero-inflated negative binomial models to characterize cell-level mediator distributions and beta…

技能形成模型中的规范化与误设AI 解读

An important class of structural models studies the determinants of skill formation and the optimal timing of interventions. In this paper, I provide new identification results for these models and investigate the effects of seemingly innocuous scale and location restrictions on parameters of interest. To do so, I first characterize the identified set of all parameters without these additional restrictions and show that important policy-relevant parameters are point…

容量约束下的最优处理分配规则AI 解读

We study treatment assignment problems under capacity constraints, where a planner aims to maximize social welfare by assigning treatments based on observable covariates. Such constraints, common when treatments are costly or limited in supply, introduce nontrivial challenges for deriving optimal statistical assignment rules because the planner needs to coordinate treatment assignment probabilities across the entire covariate distribution. To address these challenges, we…