每日简报

网络干扰下的因果推断AI 解读

We review recent advances in causal inference under interference, drawing on a complex and diverse body of work ranging from causal inference, network science, the health sciences, economics, and the social sciences. Interference in connected populations implies that the treatment assignments of units can affect the outcomes of other units directly (via spillover) and indirectly (via contagion). Examples include public health interventions, economic and financial…

聚类线性模型中的估计与排除限制AI 解读

We study linear regression models with clustered data, high-dimensional controls, and intricate exclusion restrictions. We propose a correctly centered internal instrument IV estimator that accommodates a broad class of exclusion restrictions and allows within-cluster dependence. The estimator admits a simple leave-out interpretation and is computationally tractable. We derive a central limit theorem for the associated quadratic form and propose a robust variance estimator.…

高维矩阵时间序列主效应因子模型的识别与稀疏性AI 解读

We propose a general identification framework for main effect factor models for matrix-valued time series. The classical sum-to-zero restriction on the row and column main effects is replaced by a broad class of shift-varying functions, which includes weighted averages, quantiles, and reference-unit anchors as special cases. We prove that the shift-varying property is necessary and sufficient for parameter identification, and we derive closed-form estimators under minimal…

因果测地学：沿相关与因果之间的路径估计反事实AI 解读

We introduce causal geodesy, a framework for studying the landscape of stochastic interventions that lie between the two extremes of performing no intervention and performing a sharp intervention that sets an exposure equal to a specific value. We define this framework by constructing paths of distributions that smoothly interpolate between the treatment density and a point mass at the target intervention. Thus, each path starts at a purely observational (or correlational)…

通过Johnson–Lindenstrauss变换实现差分隐私Model-X KnockoffsAI 解读

We introduce a novel privatization framework for high-dimensional controlled variable selection. Our framework enables rigorous False Discovery Rate (FDR) control under differential privacy constraints. While the Model-X knockoff procedure provides FDR guarantees by constructing provably exchangeable ``negative control" features, existing privacy mechanisms like Gaussian noise injection disrupt its core exchangeability conditions. In this work we consider privatizing the…

基于协变量平衡倾向得分的双重差分估计量AI 解读

This article develops a covariate balancing approach for the estimation of treatment effects on the treated (ATT) in a difference-in-differences (DID) research design when panel data are available. We show that the proposed covariate balancing propensity score (CBPS) DID estimator possesses several desirable properties: (i) local efficiency, (ii) double robustness in terms of consistency, (iii) double robustness in terms of inference, and (iv) faster convergence to the ATT…

平行趋势违背下双重差分政策评估的贝叶斯敏感性分析AI 解读

Violations of the parallel trends assumption pose significant challenges for causal inference in difference-in-differences (DiD) studies, especially in policy evaluations where pre-treatment dynamics and external shocks may bias estimates. In this work, we propose a Bayesian DiD framework to allow us to estimate the effect of policies when parallel trends is violated. To address potential deviations from the parallel trends assumption, we introduce a formal sensitivity…

二元结果分层实验中平均处理效应的精确与保守推断AI 解读

We extend methods for finite-sample inference about the average treatment effect (ATE) in randomized experiments with binary outcomes to accommodate stratification (blocking). We present three valid methods that differ in their computational and statistical efficiency. The first method constructs conservative, Bonferroni-adjusted confidence intervals separately for the mean response in the treatment and control groups in each stratum, then takes appropriate weighted…

剂量—暴露—响应建模对剂量响应估计与优化的收益AI 解读

In randomized dose-finding trials, although drug exposure data form a part of key information for dose selection, the evaluation of the dose-response (DR) relationship often mainly uses DR data. We examine the benefit of dose-exposure-response (DER) modeling by sequentially modeling the dose-exposure (DE) and exposure-response (ER) relationships in parameter estimation and prediction, compared with direct DR modeling without PK data. We consider ER modeling approaches with…

以剂量为工具变量、利用暴露数据稳健估计因果剂量响应关系AI 解读

An accurate estimation of the dose-response relationship is important to determine the optimal dose. For this purpose, a dose finding trial in which subjects are randomized to a few fixed dose levels is the most commonly used design. Often, the estimation uses response data only, although drug exposure data are often obtained during the trial. The use of exposure data to improve this estimation is difficult, as exposure-response relationships are typically subject to…

用于时间序列预测的高维矩阵扩散指数模型AI 解读

This paper proposes a novel diffusion-index model for forecasting when predictors are high-dimensional matrix-valued time series. We apply an $α$-PCA method to extract low-dimensional matrix factors and build a bilinear regression linking future outcomes to these factors, estimated via iterative least squares. To handle weak factor structures, we introduce a supervised screening step to select informative rows and columns. Theoretical properties, including consistency and…

同伴效应估计中的弱识别AI 解读

It is commonly accepted that some phenomena are social: for example, individuals' smoking habits often correlate with those of their peers. Such correlations can have a variety of explanations, such as direct contagion or shared socioeconomic circumstances. The network linear-in-means model is a workhorse statistical model which incorporates these peer effects by including average neighborhood characteristics as regressors. Although the model's parameters are identifiable…

DFW：用于协变量平衡与处理效应估计的新加权方案AI 解读

Estimating causal effects from observational data is challenging due to selection bias, which leads to imbalanced covariate distributions across treatment groups. Propensity score-based weighting methods are widely used to address this issue by reweighting samples to simulate a randomized controlled trial (RCT). However, the effectiveness of these methods heavily depends on the observed data and the accuracy of the propensity score estimator. For example, inverse propensity…

随机临床试验处理效应估计中的线性模型协变量调整：指导模拟的理论AI 解读

Building on key papers that were published in special issues of Biometrics in 1957 and 1982 we propose and develop a three-aspect system for evaluating the effect of fitting covariates in the analysis of designed experiments, in particular randomised clinical trials. The three aspects are: first the effect on residual mean square error, second the effect on the variance inflation factor (VIF) and third the effect on second order precision. We concentrate, in particular, on…

加权平行趋势下截距平移合成控制估计量的一致性AI 解读

The average treatment effect on the treated (ATT) in a staggered-adoption panel is estimated using an intercept-augmented synthetic-control (SCM) estimator. A weighted parallel trends plus an intercept shift, together with mild regularity on the weight vectors (non-degenerate dispersion) and expanding pre-treatment length, are sufficient for consistency allowing for heavy-tailed shocks. These conditions can be more interpretable than the autoregressive or low-rank factor…

未观测混杂的多元回归分析AI 解读

Whereas confidence intervals are used to assess uncertainty due to unmeasured individuals, confounding intervals can be used to assess uncertainty due to unmeasured attributes. Previously, we have introduced a methodology for computing confounding intervals in a simple regression setting in a paper titled ``Regression Analysis of Unmeasured Confounding." Here we extend that methodology for more general application in the context of multiple regression. Our multiple…

图神经网络的过度压缩与重连策略的因果评估AI 解读

Graph neural networks (GNNs) have exhibited state-of-the-art performance across wide-range of domains such as recommender systems, material design, and drug repurposing. Yet message-passing GNNs suffer from over-squashing -- exponential compression of long-range information from distant nodes -- which limits expressivity. Rewiring techniques can ease this bottleneck; but their practical impacts are unclear due to the lack of a direct empirical over-squashing metric. We…

随机效应模型下多区域临床试验的一致性评估与样本量计算AI 解读

Multi-regional clinical trials (MRCTs) have become common practice for drug development and global registration. Once overall significance is established, demonstrating regional consistency is critical for local health authorities. Methods for evaluating such consistency and calculating regional sample sizes have been proposed based on the fixed effects model using various criteria. To better account for the heterogeneity of treatment effects across regions, the random…

协变量缺失时协变量自适应随机试验的回归调整AI 解读

Covariate-adaptive randomization is widely used in clinical trials to balance prognostic factors, and regression adjustments are often adopted to further enhance the estimation and inference efficiency. In practice, the covariates may contain missing values. Various methods have been proposed to handle the covariate missing problem under simple randomization. However, the statistical properties of the resulting average treatment effect estimators under stratified…

早期临床试验中零膨胀生物标志物的两步检验AI 解读

In early-phase clinical trials, a predictive biomarker may identify subgroups that benefit from an experimental therapy, even when the overall average treatment effect is negligible. Recently proposed nonparametric interaction tests such as the Average Kolmogorov-Smirnov Approach (AKSA) avoid prespecified biomarker cutting points and model assumptions, but their power degrades when the biomarker distribution is zero-inflated. We propose a two-step test that partitions the…

自相关数据下 Mann–Kendall tau 的高斯分布问题AI 解读

Non-parametric Mann-Kendall tests for autocorrelated data rely on the assumption that the distribution of the normalized Mann-Kendall tau is Gaussian. While this assumption holds asymptotically for stationary autoregressive processes of order 1 (AR(1)) and simple moving average (SMA) processes when sampling over an increasingly long period, it often fails for finite-length time series. In such cases, the empirical distribution of the Mann-Kendall tau deviates significantly…

特征与自回归滞后的贝叶斯联合选择：环境与金融预测应用AI 解读

We develop a Bayesian framework for variable selection in linear regression with autocorrelated errors, accommodating lagged covariates and autoregressive structures. This setting occurs in time series applications where responses depend on contemporaneous or past explanatory variables and persistent stochastic shocks, including financial modeling, hydrological forecasting, and meteorological applications requiring temporal dependency capture. Our methodology uses…

面板与网络数据中带一般固定效应的二元 Logit 选择模型AI 解读

This paper systematically analyzes and reviews identification strategies for binary choice logit models with fixed effects in panel and network data settings. We examine both static and dynamic models with general fixed-effect structures, including individual effects, time trends, and two-way or dyadic effects. A key challenge is the incidental parameter problem, which arises from the increasing number of fixed effects as the sample size grows. We explore two main strategies…

具有 S-vine Copula 结构的近似因子模型AI 解读

We propose a novel framework for approximate factor models that integrates an S-vine copula structure to capture complex dependencies among common factors. Our estimation procedure proceeds in two steps: first, we apply principal component analysis (PCA) to extract the factors; second, we employ maximum likelihood estimation that combines kernel density estimation for the margins with an S-vine copula to model the dependence structure. Jointly fitting the S-vine copula with…