每日简报

肿瘤临床试验中非比例风险下的单样本生存检验AI 解读

In oncology, conduct well-powered time-to-event randomized clinical trials may be challenging due to limited patietns number. Many designs for single-arm trials (SATs) have recently emerged as an alternative to overcome this issue. They rely on the (modified) one-sample log-rank test (OSLRT) under the proportional hazards to compare the survival curves of an experimental and an external control group. We extend Finkelstein's formulation of OSLRT as a score test by using a…

协同干预的因果分解分析：处理多维社会差距的三重稳健机器学习方法AI 解读

Educational disparities are rooted in and perpetuate social inequalities across multiple dimensions such as race, socioeconomic status, and geography. To reduce disparities, most intervention strategies focus on a single domain and frequently evaluate their effectiveness by using causal decomposition analysis. However, a growing body of research suggests that single-domain interventions may be insufficient for individuals marginalized on multiple fronts. While interventions…

机器学习驱动的线性工具变量模型设定检验AI 解读

The linear instrumental variable (IV) model is widely used in observational studies, yet its validity hinges on strong assumptions. Classical specification tests such as the Sargan-Hansen J test are limited to overidentified settings and are therefore not applicable in the common just-identified case, where the number of instruments is equal to the number of endogenous variables. We propose a novel test for the well-specification of the linear IV model under the assumption…

线性不等式系统可解性的检验AI 解读

This paper studies the problem of testing whether a system of linear equality and inequality constraints admits a solution when the coefficients of that system may have to be estimated. We show that a wide range of inferential questions in partially identified models can be formulated as hypotheses of this form. Our approach exploits an alternative characterization of the hypothesis based on whether the value of a certain linear program is equal to zero. Building on this…

后验漂移下的过度参数化模型AI 解读

This paper investigates the impact of posterior drift on out-of-sample forecasting accuracy in overparametrized machine learning models. We document the loss in performance when the loadings of the data generating process change between the training and testing samples. This matters crucially in settings in which regime changes are likely to occur, for instance, in financial markets. Applied to equity premium forecasting, our results underline the sensitivity of a market…

事件时间终点缺失数据的临界点敏感性分析：模型法与经验法AI 解读

Treatment policy estimands are frequently favored by regulators, as they assess the effect of treatment assignment regardless of post-randomization events. Despite best efforts, missing data due to study discontinuation cannot be fully avoided and, for time-to-event endpoints, typically manifests as right censoring. Study discontinuation is often more likely following intercurrent events, particularly when it coincides with treatment discontinuation, raising concerns about…

何时能够检测到 p 值操纵？AI 解读

We show that some forms of p-hacking cannot be detected by examining the histogram of t-statistics or their p-values. Even when p-hacking is detectable, standard tests may lack power. We propose a novel test that detects every form of selective reporting that is detectable from the distribution of reported t-statistics. Our test statistic is the distance between the smoothed empirical t-curve and the set of possible honest distributions. This projection test is sharp and can…

因果森林纳入试验参与变量时的有限样本偏差—方差权衡AI 解读

Estimating conditional average treatment effects (CATE) from randomized controlled trials (RCTs) and generalizing them to broader populations is essential for personalizing treatment rules but is complicated by selection bias due to trial participation and potentially high dimensional covariates. We evaluated finite sample bias variance tradeoff for Causal Forest based CATE estimation strategies to address the selection bias. Identification theory suggests unbiased CATE…

基于贝叶斯非参数联合模型的连续时间纵向与生存数据因果中介分析AI 解读

Observational cohort data is an important source of information for understanding the causal effects of treatments on survival and the degree to which these effects are mediated through changes in disease-related risk factors. However, these analyses are often complicated by irregular data collection intervals and the presence of longitudinal confounders and mediators. We propose a causal mediation framework that jointly models longitudinal exposures, confounders, mediators,…

通过隐含干预进行因果推断AI 解读

In the context of having an instrumental variable, the standard practice in causal inference begins by targeting an effect of interest and proceeds by formulating assumptions enabling its identification. We turn this around by adhering to the interventions the observational distribution allows to identify, rather than starting with a desired causal estimand and imposing untestable conditions. The randomization of an instrument and its exclusion restriction define a class of…

利用截断策略梯度估计量估计非平稳环境中的治疗效应AI 解读

Randomized experiments (or A/B tests) are widely used to evaluate interventions in dynamic systems such as recommendation platforms, marketplaces, and digital health. In these settings, interventions affect both current and future system states, so estimating the global average treatment effect (GATE) requires accounting for temporal dynamics, which is especially challenging in the presence of nonstationarity; existing approaches suffer from high bias, high variance, or…

机器学习分布型工具变量估计中的模型风险AI 解读

We study model risk in machine-learning estimation of the Distributional Instrumental Variable Local Average Treatment Effect (D-IV-LATE), the distributional IV effect for the subpopulation induced into treatment by the instrument. The contribution is not a new neural causal estimand. We implement a reduced-form orthogonal level-score DML estimator for the covariate-adjusted D-IV-LATE target and use it to ask how much the nuisance learner matters for distributional IV…

用双重机器学习估计具有总体代表性的因果效应AI 解读

Double Machine Learning is widely used to estimate treatment effects from non-experimental data. The "residuals-on-residuals" regression (RORR) is especially popular for its simplicity and computational tractability. However, with heterogeneous treatment effects, the proper interpretation of RORR may not be well understood. We show that, for non-binary treatments with continuous dose-response functions, RORR estimates a conditional variance-weighted average of derivatives…

传统分解与因果分解何时分歧？健康差异研究的实用指南AI 解读

Identifying malleable factors that can reduce social disparities is a central objective among researchers across disciplines. Traditionally, researchers have relied on the difference-in-coefficients and Kitagawa-Oaxaca-Blinder frameworks. More recently, methods grounded in the potential outcomes framework have emerged. While these methods share the same goal of identifying drivers of disparity, they frequently yield divergent results depending on the underlying confounding…

正交化合成控制AI 解读

When conducting inference for the average treatment effect on the treated with a Synthetic Control Estimator, the vector of control weights is a nuisance parameter that is often constrained, high-dimensional, and may be only partially identified even when the average treatment effect on the treated is point-identified. All three of these features of a nuisance parameter can lead to failure of asymptotic normality for the estimate of the parameter of interest when using…

极小极大与贝叶斯最优的最佳臂识别AI 解读

This study investigates minimax and Bayes optimal strategies for fixed-budget best-arm identification. We consider an adaptive procedure consisting of a sampling phase followed by a recommendation phase. Within this framework, we design an adaptive experiment to efficiently identify the best arm, defined as the one with the highest expected outcome. In our proposed strategy, the sampling phase consists of two stages. The first stage is a pilot phase, in which we allocate…

允许反馈的非线性面板数据模型矩约束AI 解读

Many panel data methods, while allowing for general dependence between covariates and time-invariant agent-specific heterogeneity, place strong a priori restrictions on feedback: how past outcomes, covariates, and heterogeneity map into future covariate levels. Ruling out feedback entirely, as often occurs in practice, is unattractive in many dynamic economic settings. We provide a general characterization of all feedback and heterogeneity robust (FHR) moment conditions for…

部分干扰下个体处理对网络邻居的向内与向外溢出效应AI 解读

In settings where interference is present, direct effects are commonly defined as the average effect of a unit's treatment on their own outcome while fixing the treatment status or probability among interfering units. Spillover effects measure the average effect of a change in the latter while the individual's treatment status is kept fixed. Here, we define the average causal effect of a unit's treatment status on the outcome of their network neighbors, while fixing the…

非线性注意力与线性回归的插值误差比较AI 解读

Attention has become the core building block of modern machine learning (ML) by efficiently capturing the long-range dependencies among input tokens. Its inherently parallelizable structure allows for efficient performance scaling with the rapidly increasing size of both data and model parameters. Despite its central role, the theoretical understanding of Attention, especially in the nonlinear setting, is progressing at a more modest pace. This paper provides a precise…

标量对函数回归中的函数型预测变量选择与平滑系数估计AI 解读

In the framework of scalar-on-function regression models, in which several functional variables are employed to predict a scalar response, we propose a methodology for selecting relevant functional predictors while simultaneously providing accurate smooth (or, more generally, regular) estimates of the functional coefficients. We suppose that the functional predictors belong to a real separable Hilbert space, while the functional coefficients belong to a specific subspace of…

用于空间结构时间序列的拉普拉斯 P 样条分布滞后非线性模型AI 解读

Distributed lag non-linear models (DLNM) have gained popularity for modeling nonlinear lagged relationships between exposures and outcomes. When applied to spatially referenced data, these models must account for spatial dependence, a challenge that has yet to be thoroughly explored within the penalized DLNM framework. This gap is mainly due to the complex model structure and high computational demands, particularly when dealing with large spatio-temporal datasets. To…

采用单效应之和先验的 Cox 比例风险模型贝叶斯变量选择AI 解读

Motivated by genetic fine-mapping applications, we introduce a new approach to Bayesian variable selection regression (BVSR) for time-to-event (TTE) outcomes. This new approach is designed to deal with the specific challenges that arise in genetic fine-mapping, including: the presence of very strong correlations among the covariates, often exceeding 0.99; very large data sets containing potentially thousands of covariates and hundreds of thousands of samples. We accomplish…

基于翻转干预的纵向加权与修剪处理效应AI 解读

Weighting and trimming are popular methods for addressing positivity violations in causal inference. While well-studied with single-timepoint data, standard methods do not easily generalize to address non-baseline positivity violations in longitudinal data, and remain vulnerable to such violations. In this paper, we extend weighting and trimming to longitudinal data via stochastic ``flip'' interventions, which maintain the treatment status of subjects who would have received…

非终末事件时间的因果效应：抗生素使用与未来耐药性AI 解读

Comparing future antibiotic resistance levels resulting from different antibiotic treatments is challenging because some patients may survive only under one of the antibiotic treatments. We embed this problem within a semi-competing risks approach to study the causal effect on resistant infection, treated as a non-terminal event time. We argue that existing principal stratification estimands for such problems exclude patients for whom a causal effect is well-defined and is…