每日简报

非线性世界中的动态因果效应：稳健解释与识别隐患AI 解读

Applied macroeconomists frequently use impulse response estimators motivated by linear models. We study whether the estimands of such procedures have a causal interpretation when the true data generating process is in fact nonlinear. We show that vector autoregressions and linear local projections onto observed shocks or proxies identify weighted averages of causal effects regardless of the extent of nonlinearities. By contrast, identification approaches that exploit…

有序结局下原因必要性概率的识别与界限AI 解读

Although the existing causal inference literature focuses on the forward-looking perspective by estimating effects of causes, the backward-looking perspective can provide insights into causes of effects. In backward-looking causal inference, the probability of necessity measures the probability that a certain event is caused by the treatment given the observed treatment and outcome. Most existing results focus on binary outcomes. Motivated by applications with ordinal…

广义线性模型中多层模型与固定效应方法的比较AI 解读

We extend prior work comparing linear multilevel models (MLM) and fixed effect (FE) models to the generalized linear model (GLM) setting, where the coefficient on a treatment variable is of primary interest. This leads to three insights. (i) First, as in the linear setting, MLM can be thought of as a regularized form of FE (RegFE). This explains why group-level confounding can greatly bias MLM's treatment coefficient estimates. However, unlike the linear setting, there is…

自适应试验设计的置信区间之一：方法综述AI 解读

Regulatory guidance notes the need for caution in the interpretation of confidence intervals (CIs) constructed during and after an adaptive clinical trial. Conventional CIs of the treatment effects are prone to undercoverage (as well as other undesirable properties) in many adaptive designs, because they do not take into account the potential and realised trial adaptations. This paper is the first in a two-part series that explores CIs for adaptive trials. It provides a…

自适应试验设计的置信区间之二：案例研究与实践指南AI 解读

In adaptive clinical trials, the conventional confidence interval (CI) for a treatment effect is prone to undesirable properties such as undercoverage and potential inconsistency with the final hypothesis testing decision. Accordingly, as is stated in recent regulatory guidance on adaptive designs, there is the need for caution in the interpretation of CIs constructed during and after an adaptive clinical trial. However, it may be unclear which of the available CIs in the…

复杂干扰实验中的高阶因果消息传递AI 解读

Accurate estimation of treatment effects is essential for decision-making across various scientific fields. This task, however, becomes challenging in areas like social sciences and online marketplaces, where treating one experimental unit can influence outcomes for others through direct or indirect interactions. Such interference can lead to biased treatment effect estimates, particularly when the structure of these interactions is unknown. We address this challenge by…

从多模态生物医学观测中学习因果表征AI 解读

Prevalent in biomedical applications (e.g., human phenotype research), multimodal datasets can provide valuable insights into the underlying physiological mechanisms. However, current machine learning (ML) models designed to analyze these datasets often lack interpretability and identifiability guarantees, which are essential for biomedical research. Recent advances in causal representation learning have shown promise in identifying interpretable latent causal variables with…

通过保序校准稳定逆概率权重AI 解读

Inverse weighting with an estimated propensity score is widely used by estimation methods in causal inference to adjust for confounding bias. However, directly inverting propensity score estimates can lead to instability, bias, and excessive variability due to large inverse weights, especially when treatment overlap is limited. In this work, we propose a post-hoc calibration algorithm for inverse propensity weights that generates well-calibrated, stabilized weights from…

存在未观测混杂时连续处理效应的锐界AI 解读

In causal inference, treatment effects are typically estimated under the ignorability, or unconfoundedness, assumption, which is often unrealistic in observational data. By relaxing this assumption and conducting a sensitivity analysis, we introduce novel bounds and derive confidence intervals for the Average Potential Outcome (APO) - a standard metric for evaluating continuous-valued treatment or exposure effects. We demonstrate that these bounds are sharp under a…

灵活匹配设计下观察性研究的敏感性分析AI 解读

Observational studies provide invaluable opportunities to draw causal inference, but they may suffer from biases due to pretreatment difference between treated and control units. Matching is a popular approach to reduce observed covariate imbalance. To tackle unmeasured confounding, a sensitivity analysis is often conducted to investigate how robust a causal conclusion is to the strength of unmeasured confounding. For matched observational studies, Rosenbaum proposed a…

语言模型作为因果效应生成器AI 解读

In this work, we present sequence-driven structural causal models (SD-SCMs), a framework for specifying causal models with user-defined structure and language-model-defined mechanisms. We characterize how an SD-SCM enables sampling from observational, interventional, and counterfactual distributions according to the desired causal structure. We then leverage this procedure to propose a new type of benchmark for causal inference methods, generating individual-level…

统一空间混杂处理方法的工具变量框架AI 解读

Studies investigating the causal effects of spatially varying exposures on outcomes often rely on observational and spatially indexed data. A prevalent challenge is unmeasured spatial confounding, where an unobserved spatially varying variable affects both exposure and outcome, leading to biased estimates and invalid confidence intervals. There is a very large literature on spatial statistics that attempts to address unmeasured spatial confounding bias; most of this…

受高阶影响函数启发的随机实验协变量调整AI 解读

Higher-Order Influence Functions (HOIF), developed in a series of papers over the past twenty years, are a fundamental theoretical device for constructing rate-optimal causal-effect estimators from observational studies. However, the value of HOIF for analyzing well-conducted randomized controlled trials (RCT) has not been explicitly explored. In the recent U.S. Food and Drug Administration and European Medicines Agency guidelines on the practice of covariate adjustment in…

利用工具变量推断广义主分层条件下的处理效应AI 解读

We propose a general approach to inference for a broad class of models that arise in the analysis of treatment effects with discrete-valued treatments and instruments and a general-valued outcome. In addition to instrument exogeneity, the main substantive assumption in our class of models rules out certain response types by assuming that they occur with probability zero. Here, the response type refers to the vector of potential outcomes and potential treatments, and we refer…

个性化治疗方案的贝叶斯不确定性量化与多阶段变量选择AI 解读

A dynamic treatment regime is a sequence of medical decisions that adapts to the evolving clinical status of a patient over time. To facilitate personalized care, it is crucial to assess the probability of each available treatment option being optimal for a specific patient, while also identifying the key prognostic factors that determine the optimal sequence of treatments. This task has become increasingly challenging due to the growing number of individual prognostic…

因果推断的半参数方法：反事实分布与密度比模型AI 解读

In causal inference, an important problem is to quantify the effects of interventions or treatments. Many studies focus on estimating the mean causal effects; however, these estimands may offer limited insight since two distributions can share the same mean yet exhibit significant differences. Examining the causal effects from a distributional perspective provides a more thorough understanding. In this paper, we employ a semiparametric density ratio model (DRM) to…

层级与密度型因果聚类AI 解读

Understanding treatment effect heterogeneity is vital for scientific and policy research. However, identifying and evaluating heterogeneous treatment effects pose significant challenges due to the typically unknown subgroup structure. Recently, a novel approach, causal k-means clustering, has emerged to assess heterogeneity of treatment effect by applying the k-means algorithm to unknown counterfactual regression functions. In this paper, we expand upon this framework by…

利用伪值随机森林建模限制平均生存时间AI 解读

The restricted mean survival time (RMST) has become a popular measure to summarize event times in longitudinal studies. Defined as the area under the survival function up to a time horizon $τ$ > 0, the RMST can be interpreted as the life expectancy within the time interval [0, $τ$]. In addition to its straightforward interpretation, the RMST also allows for the definition of valid estimands for the causal analysis of treatment contrasts in medical studies. In this work, we…

数学教育效果：随辅导次数变化的条件平均处理效应AI 解读

This study examines the educational effect of the Academic Support Center at Kogakuin University. Following the initial assessment, it was suggested that group bias had led to an underestimation of the Center's true impact. To address this issue, the authors applied the theory of causal inference. By using T-learner, the conditional average treatment effect (CATE) of the Center's face-to-face (F2F) personal assistance program was evaluated. Extending T-learner, the authors…

多类别离散处理的变化中的变化模型AI 解读

This paper generalizes the changes-in-changes (CIC) model to handle discrete treatments with more than two categories, extending the binary case of Athey and Imbens (2006). While the original CIC model is well-suited for binary treatments, it cannot accommodate multi-category discrete treatments often found in economic and policy settings. Although recent work has extended CIC to continuous treatments, there remains a gap for multi-category discrete treatments. I introduce a…

回归能否给出具有代表性的因果效应排序？AI 解读

We examine the challenges in ranking multiple treatments based on their estimated effects when using linear regression or its popular double-machine-learning variant, the Partially Linear Model (PLM), in the presence of treatment effect heterogeneity. We demonstrate by example that overlap-weighting performed by linear models like PLM can produce Weighted Average Treatment Effects (WATE) that have rankings that are inconsistent with the rankings of the underlying Average…

利用 Copula 相等假设部分识别面板数据中的分布处理效应AI 解读

This paper aims to partially identify the distributional treatment effects (DTEs) that depend on the unknown joint distribution of treated and untreated potential outcomes. We construct the DTE bounds using panel data and allow individuals to switch between the treated and untreated states more than once over time. Individuals are grouped based on their past treatment history, and DTEs are allowed to be heterogeneous across different groups. We provide two alternative…

卡尺合成匹配：结合局部合成控制的广义半径匹配AI 解读

Matching promises transparent causal inferences for observational data, making it an intuitive approach for many applications. In practice, however, standard matching methods often perform poorly compared to modern approaches such as response-surface modeling and optimizing balancing weights. We propose Caliper Synthetic Matching (CSM) to address these challenges while preserving simple and transparent matches and match diagnostics. CSM extends Coarsened Exact Matching by…

已知有效调整集下高维因果效应估计的 PAC 保证AI 解读

Accurate estimates of causal effects play a key role in decision-making across applications such as healthcare, economics, and operations. In the absence of randomized experiments, a common approach to estimating causal effects uses \textit{covariate adjustment}. In this paper, we study covariate adjustment for discrete distributions from the PAC learning perspective, assuming knowledge of a valid adjustment set $\bZ$, which might be high-dimensional. Our first main result…