每日简报

非参数刀切工具变量估计与抗混杂替代指标AI 解读

Jackknife instrumental variable estimation (JIVE) is a classic method to leverage many weak instrumental variables (IVs) to estimate linear structural models, overcoming the bias of standard methods like two-stage least squares. In this paper, we extend the jackknife approach to nonparametric IV (NPIV) models with many weak IVs. Since NPIV characterizes the structural regression as having residuals projected onto the IV being zero, existing approaches minimize an estimate of…

用于纵向反事实回归的因果对比学习AI 解读

Estimating treatment effects over time holds significance in various domains, including precision medicine, epidemiology, economy, and marketing. This paper introduces a unique approach to counterfactual regression over time, emphasizing long-term predictions. Distinguishing itself from existing models like Causal Transformer, our approach highlights the efficacy of employing RNNs for long-term forecasting, complemented by Contrastive Predictive Coding (CPC) and Information…

结合弱工具变量与观测数据估计异质性处理效应AI 解读

Accurately predicting conditional average treatment effects (CATEs) is crucial in personalized medicine and digital platform analytics. Since the treatments of interest often cannot be directly randomized, observational data is leveraged to learn CATEs, but this approach can incur significant bias from unobserved confounding. One strategy to overcome these limitations is to leverage instrumental variables (IVs) as latent quasi-experiments, such as randomized intent-to-treat…

通过协变量选择优化平衡的自适应随机化方法AI 解读

Balancing influential covariates is crucial for valid treatment comparisons in clinical studies. While covariate-adaptive randomization is commonly used to achieve balance, its performance can be inadequate when the number of baseline covariates is large. It is therefore essential to identify the influential factors associated with the outcome and ensure balance among these critical covariates. In this article, we propose a novel adaptive randomization approach that…

通过校准贝叶斯因子提取临床试验的先验信息AI 解读

In the Bayesian framework power prior distributions are increasingly adopted in clinical trials and similar studies to incorporate external and past information, typically to inform the parameter associated to a treatment effect. Their use is particularly effective in scenarios with small sample sizes and where robust prior information is actually available. A crucial component of this methodology is represented by its weight parameter, which controls the volume of…

Logistic 回归模型的聚类稳健刀切法与自助法推断AI 解读

We study cluster-robust inference for logistic regression (logit) models. Inference based on the most commonly-used cluster-robust variance matrix estimator (CRVE) can be very unreliable. We study several alternatives. Conceptually the simplest of these, but also the most computationally demanding, involves jackknifing at the cluster level. We also propose a linearized version of the cluster-jackknife variance matrix estimator as well as linearized versions of the wild…

部分线性模型中二元工具变量的约束设计AI 解读

We study the question of how best to assign an encouragement in a randomized encouragement study. In our setting, units arrive with covariates, receive a nudge toward treatment or control, acquire one of those statuses in a way that need not align with the nudge, and finally have a response observed. The nudge can be modeled as a binary instrument if one assumes that it affects the response only via the treatment status. Our goal is to assign the nudge as a function of…

从非干预复杂系统中解析干预型动力因果关系AI 解读

Detecting and quantifying causality is a focal topic in the fields of science, engineering, and interdisciplinary studies. However, causal studies on non-intervention systems attract much attention but remain extremely challenging. Delay-embedding technique provides a promising approach. In this study, we propose a framework named Interventional Dynamical Causality (IntDC) in contrast to the traditional Constructive Dynamical Causality (ConDC). ConDC, including Granger…

基于 HAL 的因果剂量反应曲线插件估计与逐点渐近正态性AI 解读

Estimating and obtaining reliable inference for the marginally adjusted causal dose-response curve for continuous treatments without relying on parametric assumptions is a well-known statistical challenge. Parametric models risk introducing significant bias through model misspecification, compromising the accurate representation of the underlying data and dose-response relationship. On the other hand, nonparametric models face difficulties as the dose-response curve is not…

贝叶斯加性回归树的计算效率：渐近分析AI 解读

Bayesian Additive Regression Trees (BART) is a popular Bayesian non-parametric regression model that is commonly used in causal inference and beyond. Its strong predictive performance is supported by well-developed estimation theory, comprising guarantees that its posterior distribution concentrates around the true regression function at optimal rates under various data generative settings and for appropriate prior choices. However, the computational properties of the…

检测阴性设计的敏感性分析AI 解读

The test-negative design has become popular for evaluating the effectiveness of post-licensure vaccines using observational data. In addition to its logistical convenience on data collection, the design is also believed to control for the differential health-care-seeking behavior between vaccinated and unvaccinated individuals, an important while often unmeasured confounder between the vaccination and infection. Hence, the design has been employed routinely to monitor…

单人试验的因果推断AI 解读

The aim of personalized medicine is to tailor treatment decisions to individuals' characteristics. N-of-1 trials are within-person crossover trials that hold the promise of targeting individual-specific effects. While the idea behind N-of-1 trials might seem simple, analyzing and interpreting N-of-1 trials is not straightforward. Here we ground N-of-1 trials in a formal causal inference framework and formalize intuitive claims from the N-of-1 trials literature. We focus on…

面向肥胖遗传变异的超高维数据知识整合分位数回归方法AI 解读

Obesity is widely recognized as a serious and pervasive health concern. We study obesity through body mass index (BMI), which is known to be highly heritable, and identify important genetic risk factors for BMI from hundreds of thousands of single nucleotide polymorphisms (SNPs) in the Framingham Study data. Several challenges arise when using traditional genome-wide association studies (GWAS): (1) They suffer from a low power due to a combination of a limited number of…

因子模型结构变化的稳健残差检验AI 解读

In this paper, we propose an easy-to-implement residual-based specification testing procedure for detecting structural changes in factor models, which is powerful against both smooth and abrupt structural changes with unknown break dates. The proposed test is robust against the over-specified number of factors, and serially and crosssectionally correlated error processes. A new central limit theorem is given for the quadratic forms of panel data with dependence over both…

由 Lipschitz 函数索引的经验过程强逼近AI 解读

This paper presents new uniform Gaussian strong approximations for empirical processes indexed by classes of functions based on $d$-variate random vectors ($d\geq1$). First, a uniform Gaussian strong approximation is established for general empirical processes indexed by possibly Lipschitz functions, improving on previous results in the literature. In the setting considered by Rio (1994), and if the function class is Lipschitzian, our result improves the approximation rate $n^{-1/(2d)}$…

ℓ检验：利用高斯线性模型中的稀疏性改进推断AI 解读

We develop novel LASSO-based methods for coefficient testing and confidence interval construction in the Gaussian linear model with $n\ge d$. Our methods' finite-sample validity is identical to that of their ubiquitous ordinary-least-squares-$t$-test-based analogues, yet have substantially higher power when the true coefficient vector is sparse. In particular, under sparsity our coefficient test, which we call the $\ell$-test, performs like the \emph{one-sided} $t$-test…

高维线性回归中低维目标参数推断的变分贝叶斯方法AI 解读

We propose a scalable variational Bayes method for statistical inference for a single or pre-specified low-dimensional subset of the coordinates of a high-dimensional parameter in sparse linear regression. Our approach relies on assigning a mean-field approximation to the nuisance coordinates and carefully modelling the conditional distribution of the target given the nuisance. This requires only a preprocessing step and preserves the computational advantages of mean-field…

迁移学习中最小范数插值器的泛化误差AI 解读

This paper establishes the generalization error of pooled min-$\ell_2$-norm interpolation in transfer learning, where data from diverse distributions are available. Min-norm interpolators arise naturally as implicit regularized limits of modern machine learning algorithms. Prior work has characterized their out-of-distribution risk when samples from the test distribution are unavailable during training. In many applications, however, limited test samples may be available at…

ROTI-GCV：面向右旋转不变数据的广义交叉验证AI 解读

Two key tasks in high-dimensional regularized regression are tuning the regularization strength for accurate predictions and estimating the out-of-sample risk. It is known that the standard approach -- $k$-fold cross-validation -- is inconsistent in modern high-dimensional settings. While leave-one-out and generalized cross-validation remain consistent in some high-dimensional cases, they become inconsistent when samples are dependent or contain heavy-tailed covariates. As a…

VICatMix：面向离散生物医学数据的变分贝叶斯聚类与变量选择AI 解读

Effective clustering of biomedical data is crucial in precision medicine, enabling accurate stratifiction of patients or samples. However, the growth in availability of high-dimensional categorical data, including `omics data, necessitates computationally efficient clustering algorithms. We present VICatMix, a variational Bayesian finite mixture model designed for the clustering of categorical data. The use of variational inference (VI) in its training allows the model to…

面向微生物组关联分析的成分预测变量柔性聚合AI 解读

Ongoing advancements in microbiome profiling have provided unprecedented insights into the molecular dynamics of microbial communities, sparking a surge of interest in uncovering the microbiome's critical role in human health. Identifying microbial features linked to clinical outcomes, however, remains challenging due to the high-dimensional, sparse, and compositional nature of microbiome data. Additionally, many microbial taxa, although classified as distinct, may share…

学习线性结构因果模型的因果抽象AI 解读

The need for modelling causal knowledge at different levels of granularity arises in several settings. Causal Abstraction provides a framework for formalizing this problem by relating two Structural Causal Models at different levels of detail. Despite increasing interest in applying causal abstraction, e.g. in the interpretability of large machine learning models, the graphical and parametrical conditions under which a causal model can abstract another are not known.…

结合稳健协方差与条件风险价值约束的投资组合优化AI 解读

The measure of portfolio risk is an important input of the Markowitz framework. In this study, we explored various methods to obtain a robust covariance estimators that are less susceptible to financial data noise. We evaluated the performance of large-cap portfolio using various forms of Ledoit Shrinkage Covariance and Robust Gerber Covariance matrix during the period of 2012 to 2022. Out-of-sample performance indicates that robust covariance estimators can outperform the…

DISCRET：为治疗效应估计生成忠实解释AI 解读

Designing faithful yet accurate AI models is challenging, particularly in the field of individual treatment effect estimation (ITE). ITE prediction models deployed in critical settings such as healthcare should ideally be (i) accurate, and (ii) provide faithful explanations. However, current solutions are inadequate: state-of-the-art black-box models do not supply explanations, post-hoc explainers for black-box models lack faithfulness guarantees, and self-interpretable…