每日简报

基于 HAL 的因果剂量反应曲线插件估计与逐点渐近正态性AI 解读

Estimating and obtaining reliable inference for the marginally adjusted causal dose-response curve for continuous treatments without relying on parametric assumptions is a well-known statistical challenge. Parametric models risk introducing significant bias through model misspecification, compromising the accurate representation of the underlying data and dose-response relationship. On the other hand, nonparametric models face difficulties as the dose-response curve is not…

检测阴性设计的敏感性分析AI 解读

The test-negative design has become popular for evaluating the effectiveness of post-licensure vaccines using observational data. In addition to its logistical convenience on data collection, the design is also believed to control for the differential health-care-seeking behavior between vaccinated and unvaccinated individuals, an important while often unmeasured confounder between the vaccination and infection. Hence, the design has been employed routinely to monitor…

单人试验的因果推断AI 解读

The aim of personalized medicine is to tailor treatment decisions to individuals' characteristics. N-of-1 trials are within-person crossover trials that hold the promise of targeting individual-specific effects. While the idea behind N-of-1 trials might seem simple, analyzing and interpreting N-of-1 trials is not straightforward. Here we ground N-of-1 trials in a formal causal inference framework and formalize intuitive claims from the N-of-1 trials literature. We focus on…

面向肥胖遗传变异的超高维数据知识整合分位数回归方法AI 解读

Obesity is widely recognized as a serious and pervasive health concern. We study obesity through body mass index (BMI), which is known to be highly heritable, and identify important genetic risk factors for BMI from hundreds of thousands of single nucleotide polymorphisms (SNPs) in the Framingham Study data. Several challenges arise when using traditional genome-wide association studies (GWAS): (1) They suffer from a low power due to a combination of a limited number of…

学习线性结构因果模型的因果抽象AI 解读

The need for modelling causal knowledge at different levels of granularity arises in several settings. Causal Abstraction provides a framework for formalizing this problem by relating two Structural Causal Models at different levels of detail. Despite increasing interest in applying causal abstraction, e.g. in the interpretability of large machine learning models, the graphical and parametrical conditions under which a causal model can abstract another are not known.…

DISCRET：为治疗效应估计生成忠实解释AI 解读

Designing faithful yet accurate AI models is challenging, particularly in the field of individual treatment effect estimation (ITE). ITE prediction models deployed in critical settings such as healthcare should ideally be (i) accurate, and (ii) provide faithful explanations. However, current solutions are inadequate: state-of-the-art black-box models do not supply explanations, post-hoc explainers for black-box models lack faithfulness guarantees, and self-interpretable…

用于多元时间序列因果预测的组合式动态建模AI 解读

Theoretical developments in sequential Bayesian analysis of multivariate dynamic models underlie new methodology for causal prediction. This extends the utility of existing models with computationally efficient methodology, enabling routine exploration of Bayesian counterfactual analyses with multiple selected time series as synthetic controls. Methodological contributions also define the concept of outcome adaptive modelling to monitor and inferentially respond to changes…

面板数据中的异质性处理效应AI 解读

We address a core problem in causal inference: estimating heterogeneous treatment effects using panel data with general treatment patterns. Many existing methods either do not utilize the potential underlying structure in panel data or have limitations in the allowable treatment patterns. In this work, we propose and evaluate a new method that first partitions observations into disjoint clusters with similar treatment effects using a regression tree, and then leverages the…

基于最优传输的多元随机占优及模型基准比较AI 解读

Stochastic dominance is an important concept in probability theory, econometrics and social choice theory for robustly modeling agents' preferences between random outcomes. While many works have been dedicated to the univariate case, little has been done in the multivariate scenario, wherein an agent has to decide between different multivariate outcomes. By exploiting a characterization of multivariate first stochastic dominance in terms of couplings, we introduce a…

带阈值识别的生物标志物引导自适应富集生存试验设计AI 解读

Biomarker-guided designs are increasingly used to evaluate personalized treatments based on patients' biomarker status in Phase II and III clinical trials. With adaptive enrichment, these designs can improve the efficiency of evaluating the treatment effect in biomarker-positive patients by increasing their proportion in the randomized trial. While time-to-event outcomes are often used as the primary endpoint to measure treatment effects for a new therapy in severe diseases…

Harold Zuercher 的偏好具有时间可分性吗？AI 解读

This paper proposes an empirical model of dynamic discrete choice to allow for non-separable time preferences, generalizing the well-known Rust (1987) model. Under weak conditions, we show the existence of value functions and hence well-defined optimal choices. We construct a contraction mapping of the value function and propose an estimation method similar to Rust's nested fixed point algorithm. Finally, we apply the framework to the bus engine replacement data. We improve…

通过稳健估计处理暴露缺失的因果推断AI 解读

How to deal with missing data in observational studies is a common concern for causal inference. When the covariates are missing at random (MAR), multiple approaches have been provided to help solve the issue. However, if the exposure is MAR, few approaches are available and careful adjustments on both missingness and confounding issues are required to ensure a consistent estimate of the true causal effect on the response. In this article, a new inverse probability weighting…

法官工具变量设计中的多维聚类AI 解读

Estimates in judge designs run the risk of being biased due to the many judge identities that are implicitly or explicitly used as instrumental variables. The usual method to analyse judge designs, via a leave-out mean instrument, eliminates this many instrument bias only in case the data are clustered in at most one dimension. What is left out in the mean defines this clustering dimension. How most judge designs cluster their standard errors, however, implies that there are…

存在测量误差时的协变量平衡AI 解读

In recent years, there is a growing body of causal inference literature focusing on covariate balancing methods. These methods eliminate observed confounding by equalizing covariate moments between the treated and control groups. The validity of covariate balancing relies on an implicit assumption that all covariates are accurately measured, which is frequently violated in observational studies. Nevertheless, the impact of measurement error on covariate balancing is unclear,…

无法直接分配处理时的自适应实验AI 解读

This paper introduces the \emph{confounded pure exploration transductive linear bandit} (\texttt{CPET-LB}) problem. As a motivating example, often online services cannot directly assign users to specific control or treatment experiences either for business or practical reasons. In these settings, naively comparing treatment and control groups that may result from self-selection can lead to biased estimates of underlying treatment effects. Instead, online services can employ…

合成控制模型中用于供体选择的溢出检测AI 解读

Synthetic control (SC) models are widely used to estimate causal effects in settings with observational time-series data. To identify the causal effect on a target unit, SC requires the existence of correlated units that are not impacted by the intervention. Given one of these potential donor units, how can we decide whether it is in fact a valid donor - that is, one not subject to spillover effects from the intervention? Such a decision typically requires appealing to…

传送器理论：跨世界反事实因果建模的一般图示方法AI 解读

Leveraging the development of structural causal model (SCM), researchers can establish graphical models for exploring the causal mechanisms behind machine learning techniques. As the complexity of machine learning applications rises, single-world interventionism causal analysis encounters theoretical adaptation limitations. Accordingly, cross-world counterfactual approach extends our understanding of causality beyond observed data, enabling hypothetical reasoning about…

多维福利比较的贝叶斯推断AI 解读

Using both single-index measures and stochastic dominance concepts, we show how Bayesian inference can be used to make multivariate welfare comparisons. A four-dimensional distribution for the well-being attributes income, mental health, education, and happiness are estimated via Bayesian Markov chain Monte Carlo using unit-record data taken from the Household, Income and Labour Dynamics in Australia survey. Marginal distributions of beta and gamma mixtures and discrete…

调查未回应下受限随机占优的面板数据检验：理论与澳大利亚贫困评估AI 解读

This paper lays the groundwork for a unifying approach to stochastic dominance testing under survey nonresponse that integrates the partial identification approach to incomplete data and design-based inference for complex survey data. We propose a novel inference procedure for restricted $s$th-order stochastic dominance, tailored to accommodate a broad spectrum of nonresponse assumptions. The method uses pseudo-empirical likelihood to formulate the test statistic and…

多元线性与路径分析模型中基于 Copula 的因果效应估计AI 解读

Regression analysis is one of the most popularly used statistical technique which only measures the direct effect of independent variables on dependent variable. Path analysis looks for both direct and indirect effects of independent variables and may overcome several hurdles allied with regression models. It utilizes one or more structural regression equations in the model which are used to estimate the unknown parameters. The aim of this work is to study the path analysis…

因果响应者检测AI 解读

We introduce the causal responders detection (CARD), a novel method for responder analysis that identifies treated subjects who significantly respond to a treatment. Leveraging recent advances in conformal prediction, CARD employs machine learning techniques to accurately identify responders while controlling the false discovery rate in finite sample sizes. Additionally, we incorporate a propensity score adjustment to mitigate bias arising from non-random treatment…

利用时间结构改善因果发现的有限样本表现AI 解读

Methods of causal discovery aim to identify causal structures in a data driven way. Existing algorithms are known to be unstable and sensitive to statistical errors, and are therefore rarely used with biomedical or epidemiological data. We present an algorithm that efficiently exploits temporal structure, so-called tiered background knowledge, for estimating causal structures. Tiered background knowledge is readily available from, e.g., cohort or registry data. When used…

序列数据中选择结构的检测与识别AI 解读

We argue that the selective inclusion of data points based on latent objectives is common in practical situations, such as music sequences. Since this selection process often distorts statistical analysis, previous work primarily views it as a bias to be corrected and proposes various methods to mitigate its effect. However, while controlling this bias is crucial, selection also offers an opportunity to provide a deeper insight into the hidden generation process, as it is a…

分布因果效应的工具变量估计AI 解读

Estimating the causal effect of a treatment on the entire response distribution is an important yet challenging task. For instance, one might be interested in how a pension plan affects not only the average savings among all individuals but also how it affects the entire savings distribution. While sufficiently large randomized studies can be used to estimate such distributional causal effects, they are often either not feasible in practice or involve non-compliance. A…