每日简报

专业能力的定义及其处理效应估计应用AI 解读

Decision-makers are often experts of their domain and take actions based on their domain knowledge. Doctors, for instance, may prescribe treatments by predicting the likely outcome of each available treatment. Actions of an expert thus naturally encode part of their domain knowledge, and can help make inferences within the same domain: Knowing doctors try to prescribe the best treatment for their patients, we can tell treatments prescribed more frequently are likely to be…

使用匹配自适应随机化推断重新评估激素替代疗法对心脏病的影响AI 解读

Matching is an appealing way to design observational studies because it mimics the data structure produced by stratified randomized trials, pairing treated individuals with similar controls. After matching, inference is often conducted using methods tailored for stratified randomized trials in which treatments are permuted within matched pairs. However, in observational studies, matched pairs are not predetermined before treatment; instead, they are constructed based on…

中介效应的改进检验AI 解读

Testing for a mediation effect is important in many disciplines, but is made difficult - even asymptotically - by the influence of nuisance parameters. Classical tests such as likelihood ratio (LR) and Wald (Sobel) tests have very poor power properties in parts of the parameter space, and many attempts have been made to produce improved tests, with limited success. In this paper we show that augmenting the critical region of the LR test can produce a test with much improved…

带模型选择的正则化 DeepIVAI 解读

In this paper, we study nonparametric estimation of instrumental variable (IV) regressions. While recent advancements in machine learning have introduced flexible methods for IV estimation, they often encounter one or more of the following limitations: (1) restricting the IV regression to be uniquely identified; (2) requiring minimax computation oracle, which is highly unstable in practice; (3) absence of model selection procedure. In this paper, we present the first method…

通过连续时间建模估计孟德尔随机化中的时变暴露效应AI 解读

Mendelian randomization is an instrumental variable method that utilizes genetic information to investigate the causal effect of a modifiable exposure on an outcome. In most cases, the exposure changes over time. Understanding the time-varying causal effect of the exposure can yield detailed insights into mechanistic effects and the potential impact of public health interventions. Recently, a growing number of Mendelian randomization studies have attempted to explore…

通过独立性查询预言机检验马尔可夫等价类成员资格AI 解读

Understanding causal relationships between variables is a fundamental problem with broad impact in numerous scientific fields. While extensive research has been dedicated to learning causal graphs from data, its complementary concept of testing causal relationships has remained largely unexplored. While learning involves the task of recovering the Markov equivalence class (MEC) of the underlying causal graph from observational data, the testing counterpart addresses the…

观察研究因果推断中 Mann–Whitney–Wilcoxon 秩和统计量的双重稳健估计AI 解读

The Mann-Whitney-Wilcoxon rank sum test (MWWRST) is a widely used method for comparing two treatment groups in randomized control trials, particularly when dealing with highly skewed data. However, when applied to observational study data, the MWWRST often yields invalid results for causal inference. To address this limitation, Wu et al. (2014) introduced an approach that incorporates inverse probability weighting (IPW) into this rank-based statistics to mitigate confounding…

中位数处理效应的近似极限AI 解读

Average Treatment Effect (ATE) estimation is a well-studied problem in causal inference. However, it does not necessarily capture the heterogeneity in the data, and several approaches have been proposed to tackle the issue, including estimating the Quantile Treatment Effects. In the finite population setting containing $n$ individuals, with treatment and control values denoted by the potential outcome vectors $\mathbf{a}, \mathbf{b}$, much of the prior work focused on…

用长期平均风险评估免疫治疗的延迟获益AI 解读

Delayed treatment effects on time-to-event outcomes have often been observed in randomized controlled studies of cancer immunotherapies. In the case of delayed onset of treatment effect, the conventional test/estimation approach using the log-rank test for between-group comparison and Cox's hazard ratio to estimate the magnitude of treatment effect is not optimal, because the log-rank test is not the most powerful option, and the interpretation of the resulting hazard ratio…

用于纵向异质性处理效应推断的常微分方程发现AI 解读

Inferring unbiased treatment effects has received widespread attention in the machine learning community. In recent years, our community has proposed numerous solutions in standard settings, high-dimensional treatment settings, and even longitudinal settings. While very diverse, the solution has mostly relied on neural networks for inference and simultaneous correction of assignment bias. New approaches typically build on top of previous approaches by proposing new (or…

用于主分层因果效应的贝叶斯非参数树模型AI 解读

Principal stratification analysis evaluates how causal effects of a treatment on a primary outcome vary across strata of units defined by their treatment effect on some intermediate quantity. This endeavor is substantially challenged when the intermediate variable is continuously scaled and there are infinitely many basic principal strata. We employ a Bayesian nonparametric approach to flexibly evaluate treatment effects across flexibly-modeled principal strata. The approach…

局部误设双部网络中的稳健推断AI 解读

This paper introduces a methodology to conduct robust inference in bipartite networks under local misspecification. We focus on a class of dyadic network models with misspecified conditional moment restrictions. The framework of misspecification is local, as the effect of misspecification varies with the sample size. We utilize this local asymptotic approach to construct a robust estimator that is minimax optimal for the mean square error within a neighborhood of…

基于机器学习元学习器的电力市场减排策略因果分析AI 解读

This study employs the Causal Machine Learning (CausalML) statistical method to analyze the influence of electricity pricing policies on carbon dioxide (CO2) levels in the household sector. Investigating the causality between potential outcomes and treatment effects, where changes in pricing policies are the treatment, our analysis challenges the conventional wisdom surrounding incentive-based electricity pricing. The study's findings suggest that adopting such policies may…

近似随机占优检验AI 解读

We introduce a 2-dimensional stochastic dominance (2DSD) index to characterize both strict and almost stochastic dominance. Based on this index, we derive an estimator for the minimum violation ratio (MVR), also known as the critical parameter, of the almost stochastic ordering condition between two variables. We determine the asymptotic properties of the empirical 2DSD index and MVR for the most frequently used stochastic orders. We also provide conditions under which the…

美国阿片类药物流行高成本模拟中的处理效应估计模型选择AI 解读

Agent-based simulation with a synthetic population can help us compare different treatment conditions while keeping everything else constant within the same population (i.e., as digital twins). Such population-scale simulations require large computational power (i.e., CPU resources) to get accurate estimates for treatment effects. We can use meta models of the simulation results to circumvent the need to simulate every treatment condition. Selecting the best estimating model…

动态选择下实验与观察数据结合的信息含量AI 解读

This paper addresses the challenge of estimating the Average Treatment Effect on the Treated Survivors (ATETS; Vikstrom et al., 2018) in the absence of long-term experimental data, utilizing available long-term observational data instead. We establish two theoretical results. First, it is impossible to obtain informative bounds for the ATETS with no model restriction and no auxiliary data. Second, to overturn this negative result, we explore as a promising avenue the recent…

用于因果推断的样本经验似然方法AI 解读

Causal inference is crucial for understanding the true impact of interventions, policies, or actions, enabling informed decision-making and providing insights into the underlying mechanisms that shape our world. In this paper, we establish a framework for the estimation and inference of average treatment effects using a two-sample empirical likelihood function. Two different approaches to incorporating propensity scores are developed. The first approach introduces propensity…

工具变量模型中的抗污染推断AI 解读

The classical tests in the instrumental variable model can behave arbitrarily if the data is contaminated. For instance, one outlying observation can be enough to change the outcome of a test. We develop a framework to construct testing procedures that are robust to weak instruments, outliers and heavy-tailed errors in the instrumental variable model. The framework is constructed upon M-estimators. By deriving the influence functions of the classical weak instrument robust…

协变量调整的生存概率组序贯比较AI 解读

In confirmatory clinical trials, survival outcomes are frequently studied and interim analyses for efficacy and/or futility are often desirable. Methods such as the log rank test and Cox regression model are commonly used to compare treatments in this setting. They rely on a proportional hazards (PH) assumption and are subject to type I error rate inflation and loss of power when PH are violated. Such violations may be expected a priori, particularly when the mechanisms of…

网络关联数据的高维因子分析AI 解读

Factor analysis is a widely used statistical tool in many scientific disciplines, such as psychology, economics, and sociology. As observations linked by networks become increasingly common, incorporating network structures into factor analysis remains an open problem. In this paper, we focus on high-dimensional factor analysis involving network-connected observations, and propose a generalized factor model with latent factors that account for both the network structure and…

基于两个次序统计量的反卷积AI 解读

Economic data are often contaminated by measurement errors and truncated by ranking. This paper shows that the classical measurement error model with independent and additive measurement errors is identified nonparametrically using only two order statistics of repeated measurements. The identification result confirms a hypothesis by Athey and Haile (2002) for a symmetric ascending auction model with unobserved heterogeneity. Extensions allow for heterogeneous measurement…

惩罚化偏差缩减的双重稳健因果推断：融合非概率样本与设计调查AI 解读

Causal inference on the average treatment effect (ATE) using non-probability samples, such as electronic health records (EHR), faces challenges from sample selection bias and high-dimensional covariates. This requires considering a selection model alongside treatment and outcome models that are typical ingredients in causal inference. This paper considers integrating large non-probability samples with external probability samples from a design survey, addressing moderately…

外部有效性中的重叠条件违反AI 解读

Estimating externally valid causal effects is a foundational problem in the social and biomedical sciences. Generalizing or transporting causal estimates from an experimental sample to a target population of interest relies on an overlap assumption between the experimental sample and the target population--i.e., all units in the target population must have a non-zero probability of being included in the experiment. In practice, having full overlap between an experimental…

C-XGBoost：用于因果效应估计的树提升模型AI 解读

Causal effect estimation aims at estimating the Average Treatment Effect as well as the Conditional Average Treatment Effect of a treatment to an outcome from the available data. This knowledge is important in many safety-critical domains, where it often needs to be extracted from observational data. In this work, we propose a new causal inference model, named C-XGBoost, for the prediction of potential outcomes. The motivation of our approach is to exploit the superiority of…