每日简报

两样本汇总数据孟德尔随机化中的修正去偏逆方差加权估计AI 解读

Mendelian randomization uses genetic variants as instrumental variables to make causal inferences about the effects of modifiable risk factors on diseases from observational data. One of the major challenges in Mendelian randomization is that many genetic variants are only modestly or even weakly associated with the risk factor of interest, a setting known as many weak instruments. Many existing methods, such as the popular inverse-variance weighted (IVW) method, could be…

多变量孟德尔随机化的一种更稳健方法AI 解读

Multivariable Mendelian randomization (MVMR) uses genetic variants as instrumental variables to infer the direct effects of multiple exposures on an outcome. However, unlike univariable Mendelian randomization, MVMR often faces greater challenges with many weak instruments, which can lead to bias not necessarily toward zero and inflation of type I errors. In this work, we introduce a new asymptotic regime that allows exposures to have varying degrees of instrument strength,…

SSRIs 对抑郁症的条目层面异质性治疗效应AI 解读

In analysis of randomized controlled trials (RCTs) with patient-reported outcome measures (PROMs), Item Response Theory (IRT) models that allow for heterogeneity in the treatment effect at the item level merit consideration. These models for ``item-level heterogeneous treatment effects'' (IL-HTE) can provide more accurate statistical inference, allow researchers to better generalize their results, and resolve critical identification problems in the estimation of interaction…

缺失数据下因果效应的可恢复性：一项纵向案例研究AI 解读

Missing data in multiple variables is a common issue. We investigate the applicability of the framework of graphical models for handling missing data to a complex longitudinal pharmacological study of children with HIV treated with an efavirenz-based regimen as part of the CHAPAS-3 trial. Specifically, we examine whether the causal effects of interest, defined through static interventions on multiple continuous variables, can be recovered (estimated consistently) from the…

双重机器学习因果推断中的超参数调优：模拟研究AI 解读

Proper hyperparameter tuning is essential for achieving optimal performance of modern machine learning (ML) methods in predictive tasks. While there is an extensive literature on tuning ML learners for prediction, there is only little guidance available on tuning ML learners for causal machine learning and how to select among different ML learners. In this paper, we empirically assess the relationship between the predictive performance of ML methods and the resulting causal…

将大语言模型融入因果发现：统计因果方法AI 解读

In practical statistical causal discovery (SCD), embedding domain expert knowledge as constraints into the algorithm is important for reasonable causal models reflecting the broad knowledge of domain experts, despite the challenges in the systematic acquisition of background knowledge. To overcome these challenges, this paper proposes a novel method for causal inference, in which SCD and knowledge-based causal inference (KBCI) with a large language model (LLM) are…

工具变量下因果效应的非参数识别与有效估计AI 解读

Instrumental variables are widely used in econometrics and epidemiology for identifying and estimating causal effects when an exposure of interest is confounded by unmeasured factors. Despite this popularity, the assumptions invoked to justify the use of instruments differ substantially across the literature. Similarly, statistical approaches for estimating the resulting causal quantities vary considerably, and often rely on strong parametric assumptions. In this work, we…

CausalMetaR：用于具有因果解释的荟萃分析的 R 包AI 解读

Researchers would often like to leverage data from a collection of sources (e.g., primary studies in a meta-analysis) to estimate causal effects in a target population of interest. However, traditional meta-analytic methods do not produce causally interpretable estimates for a well-defined target population. In this paper, we present the CausalMetaR R package, which implements efficient and robust methods to estimate causal effects in a given internal or external target…

随机对照试验中 Logistic 回归的预后协变量调整AI 解读

Randomized controlled trials (RCTs) with binary primary endpoints introduce novel challenges for inferring the causal effects of treatments. The most significant challenge is non-collapsibility, in which the conditional odds ratio estimand under covariate adjustment differs from the unconditional estimand in the logistic regression analysis of RCT data. This issue gives rise to apparent paradoxes, such as the variance of the estimator for the conditional odds ratio from a…

优化自适应实验：统一遗憾最小化与最优臂识别AI 解读

Practitioners conducting adaptive experiments often encounter two competing priorities: maximizing total welfare (or `reward') through effective treatment assignment and swiftly concluding experiments to implement population-wide treatments. Current literature addresses these priorities separately, with regret minimization studies focusing on the former and best-arm identification research on the latter. This paper bridges this divide by proposing a unified model that…

DoubleMLDeep：利用多模态数据估计因果效应AI 解读

This paper explores the use of unstructured, multimodal data, namely text and images, in causal inference and treatment effect estimation. We propose a neural network architecture that is adapted to the double machine learning (DML) framework, specifically the partially linear model. An additional contribution of our paper is a new method to generate a semi-synthetic dataset which can be used to evaluate the performance of causal effect estimation in the presence of text and…

利用多来源数据高效估计亚组处理效应AI 解读

Investigators often use multi-source data (e.g., multi-center trials, meta-analyses of randomized trials, pooled analyses of observational cohorts) to learn about the effects of interventions in subgroups of some well-defined target population. Such a target population can correspond to one of the data sources of the multi-source data or an external population in which the treatment and outcome information may not be available. We develop and evaluate methods for using…

条件相对效应可迁移假设下的因果推断AI 解读

When extending inferences from a randomized trial to a new target population, the transportability condition for conditional difference effect measures is invoked to identify the marginal causal mean difference in the target population. However, many clinical investigators believe that conditional relative effect measures are more likely to be "transportable" between populations. Here, we examine the identification and estimation of the marginal counterfactual mean…

处理时变混杂的灵活贝叶斯生存分析 g 公式AI 解读

In longitudinal observational studies with time-to-event outcomes, a common objective in causal analysis is to estimate the causal survival curve under hypothetical intervention scenarios. The g-formula is a useful tool for this analysis. To enhance the traditional parametric g-formula, we developed an alternative g-formula estimator, which incorporates the Bayesian Additive Regression Trees (BART) into the modeling of the time-evolving generative components, aiming to…

何时可以使用双向固定效应：与新型动态双重差分估计量的比较AI 解读

The conventional Two-Way Fixed-Effects (TWFE) estimator has come under scrutiny lately. Recent literature has revealed potential shortcomings of TWFE when the treatment effects are heterogeneous. Scholars have developed new advanced dynamic Difference-in-Differences (DiD) estimators to tackle these potential shortcomings. However, confusion remains in applied research as to when the conventional TWFE is biased and what issues the novel estimators can and cannot address. In…

借助大语言模型发现隐含变量并开展因果发现与推理AI 解读

Revealing hidden causal variables alongside the underlying causal mechanisms is essential to the development of science. Despite the progress in the past decades, existing practice in causal discovery (CD) heavily relies on high-quality measured variables, which are usually given by human experts. In fact, the lack of well-defined high-level variables behind unstructured data has been a longstanding roadblock to a broader real-world application of CD. This procedure can…

结合 T-learning 与 DR-learning：因果对比的 oracle 有效估计框架AI 解读

We introduce efficient plug-in (EP) learning, a novel framework for the estimation of heterogeneous causal contrasts, such as the conditional average treatment effect and conditional relative risk. The EP-learning framework enjoys the same oracle efficiency as Neyman-orthogonal learning strategies, such as DR-learning and R-learning, while addressing some of their primary drawbacks: (i) their practical applicability can be hindered by non-convex loss functions; and (ii) they…

因果潜在因子模型中的双重稳健推断AI 解读

This article introduces a new estimator of average treatment effects under unobserved confounding in modern data-rich environments featuring large numbers of units and outcomes. The proposed estimator is doubly robust, combining outcome imputation, inverse probability weighting, and a novel cross-fitting procedure for matrix completion. We derive finite-sample and asymptotic guarantees, and show that the error of the new estimator converges to a mean-zero Gaussian…

动态线性面板模型的 Arellano–Bond LASSO 估计量AI 解读

The Arellano-Bond estimator is a fundamental method for dynamic panel data models, widely used in practice. It can be severely biased when the time series dimension of the data, $T$, is long. The source of the bias is the large degree of overidentification. We propose a simple two-step approach to deal with this problem. The first step applies LASSO to the cross-section data at each time period to select the most informative moment conditions, exploiting the approximately…

基于高斯过程网络的贝叶斯因果推断AI 解读

Causal discovery and inference from observational data is an essential problem in statistics posing both modeling and computational challenges. These are typically addressed by imposing strict assumptions on the joint distribution such as linearity. We consider the problem of the Bayesian estimation of the effects of hypothetical interventions in the Gaussian Process Network (GPN) model, a flexible causal framework which allows describing the causal relationships…

效应量指标的估计与解释AI 解读

Effect size estimates are thought to capture the collective, two-way response to an intervention or exposure in a three-way problem among the intervention/exposure, various confounders and the outcome. For meaningful causal inference from the estimated effect size, the joint distribution of observed confounders must be identical across all intervention/exposure groups. However, real-world observational studies and even randomized clinical trials often lack such structural…

删失数据下纵向替代标志物的稳健评估AI 解读

The development of statistical methods to evaluate surrogate markers is an active area of research. In many clinical settings, the surrogate marker is not simply a single measurement but is instead a longitudinal trajectory of measurements over time, e.g., fasting plasma glucose measured every 6 months for 3 years. In general, available methods developed for the single-surrogate setting cannot accommodate a longitudinal surrogate marker. Furthermore, many of the methods have…

弱一致性条件下的局部自然因果学习算法AI 解读

By relaxing conditions for natural structure learning algorithms, a family of constraint-based algorithms containing all exact structure learning algorithms under the faithfulness assumption, we define localised natural structure learning algorithms (LoNS). We also provide a set of necessary and sufficient assumptions for consistency of LoNS, which can be thought of as a strict relaxation of the restricted faithfulness assumption. We provide a practical LoNS algorithm that…

多维回归不连续设计的操纵检验AI 解读

The causal inference model proposed by Lee (2008) for the regression discontinuity design (RDD) relies on assumptions that imply the continuity of the density of the assignment (running) variable. The test for this implication is commonly referred to as the manipulation test and is regularly reported in applied research to strengthen the design's validity. The multidimensional RDD (MRDD) extends the RDD to contexts where treatment assignment depends on several running…