每日简报

协变量调整回归函数的去偏推断AI 解读

In this article, we study nonparametric inference for a covariate-adjusted regression function. This parameter captures the average association between a continuous exposure and an outcome after adjusting for other covariates. In particular, under certain causal conditions, this parameter corresponds to the average outcome had all units been assigned to a specific exposure level, known as the causal dose-response curve. We propose a debiased local linear estimator of the…

个体化处理效应预测的评价：区分度与校准的模型视角AI 解读

In recent years, there has been a growing interest in the prediction of individualized treatment effects. While there is a rapidly growing literature on the development of such models, there is little literature on the evaluation of their performance. In this paper, we aim to facilitate the validation of prediction models for individualized treatment effects. The estimands of interest are defined as based on the potential outcomes framework, which facilitates a comparison of…

混杂部分可观测马尔可夫决策过程的策略梯度方法AI 解读

In this paper, we propose a policy gradient method for confounded partially observable Markov decision processes (POMDPs) with continuous state and observation spaces in the offline setting. We first establish a novel identification result to non-parametrically estimate any history-dependent policy gradient under POMDPs using the offline data. The identification enables us to solve a sequence of conditional moment restrictions and adopt the min-max learning procedure with…

时间或空间依赖实验中的策略评估AI 解读

The aim of this paper is to establish a causal link between the policies implemented by technology companies and the outcomes they yield within intricate temporal and/or spatial dependent experiments. We propose a novel temporal/spatio-temporal Varying Coefficient Decision Process (VCDP) model, capable of effectively capturing the evolving treatment effects in situations characterized by temporal and/or spatial dependence. Our methodology encompasses the decomposition of the…

中介分析中适用于混合数据类型的一类有向无环图AI 解读

We propose a unified class of generalized structural equation models (GSEMs) with data of mixed types in mediation analysis, including continuous, categorical, and count variables. Such models extend substantially the classical linear structural equation model to accommodate many data types arising from the application of mediation analysis. Invoking the hierarchical modeling approach, we specify GSEMs by a copula joint distribution of outcome variable, mediator and exposure…

基于对照组插补的纵向缺失数据多重稳健估计AI 解读

Longitudinal studies are often subject to missing data. The ICH E9(R1) addendum addresses the importance of defining a treatment effect estimand with the consideration of intercurrent events. Jump-to-reference (J2R) is one classically envisioned control-based scenario for the treatment effect evaluation using the hypothetical strategy, where the participants in the treatment group after intercurrent events are assumed to have the same disease progress as those with identical…

加权平均处理效应中稳健三明治方差估计的保守性评估AI 解读

In causal inference, the Inverse Probability Weighting (IPW) estimator is commonly used to estimate causal effects for estimands within the class of Weighted Average Treatment Effect (WATE). When constructing confidence intervals (CIs), robust sandwich variance estimators are frequently used for practical reasons. Although these estimators are easy to calculate using widely-used statistical software, they often yield narrow CIs for commonly applied estimands, such as the…

通过 Softmax 近似对最优动态政策进行推断AI 解读

Estimating optimal dynamic policies from offline data is a fundamental problem in dynamic decision making. In the context of causal inference, the problem is known as estimating the optimal dynamic treatment regime. Even though there exists a plethora of methods for estimation, constructing confidence intervals for the value of the optimal regime and structural parameters associated with it is inherently harder, as it involves non-linear and non-differentiable functionals of…

用于因果推断的最优恢复AI 解读

Problems in causal inference can be fruitfully addressed using signal processing techniques. As an example, it is crucial to successfully quantify the causal effects of an intervention to determine whether the intervention achieved desired outcomes. We present a new geometric signal processing approach to classical synthetic control called ellipsoidal optimal recovery (EOpR), for estimating the unobservable outcome of a treatment unit. EOpR provides policy evaluators with…

寻找具有显著处理效应的子群体AI 解读

Researchers often run resource-intensive randomized controlled trials (RCTs) to estimate the causal effects of interventions on outcomes of interest. Yet these outcomes are often noisy, and estimated overall effects can be small or imprecise. Nevertheless, we may still be able to produce reliable evidence of the efficacy of an intervention by finding subgroups with significant effects. In this paper, we propose a machine-learning method that is specifically optimized for…

存在未测混杂时中间变量的因果效应AI 解读

We present new results on average causal effects in settings with unmeasured exposure-outcome confounding. Our results are motivated by a class of estimands, e.g., frequently of interest in medicine and public health, that are currently not targeted by standard approaches for average causal effects. We recognize these estimands as queries about the average causal effect of an intervening variable. We anchor our introduction of these estimands in an investigation of the role…

从生存结局边际结构模型生成模拟数据AI 解读

Marginal structural models (MSMs) are often used to estimate causal effects of treatments on survival time outcomes from observational data when time-dependent confounding may be present. They can be fitted using, e.g., inverse probability of treatment weighting (IPTW). It is important to evaluate the performance of statistical methods in different scenarios, and simulation studies are a key tool for such evaluations. In such simulation studies, it is common to generate data…

利用代理变量从低频采样时间序列发现因果结构AI 解读

Inferring causal structures from time series data is the central interest of many scientific inquiries. A major barrier to such inference is the problem of subsampling, i.e., the frequency of measurement is much lower than that of causal influence. To overcome this problem, numerous methods have been proposed, yet either was limited to the linear case or failed to achieve identifiability. In this paper, we propose a constraint-based algorithm that can identify the entire…

因果森林对流形数据结构的自适应AI 解读

Researchers often hold the belief that random forests are "the cure to the world's ills" (Bickel, 2010). But how exactly do they achieve this? Focused on the recently introduced causal forests (Athey and Imbens, 2016; Wager and Athey, 2018), this manuscript aims to contribute to an ongoing research trend towards answering this question, proving that causal forests can adapt to the unknown covariate manifold structure. In particular, our analysis shows that a causal forest…

协变量自适应最小化随机分配下分层不平衡协方差的一致估计AI 解读

Pocock and Simon's minimization method is a popular approach for covariate-adaptive randomization in clinical trials. Valid statistical inference with data collected under the minimization method requires the knowledge of the limiting covariance matrix of within-stratum imbalances, whose existence is only recently established. In this work, we propose a bootstrap-based estimator for this limit and establish its consistency, in particular, by Le Cam's third lemma. As an…

断点的设计：从断点回归到最优分区AI 解读

Discontinuities can be fairly arbitrary but also cause a significant impact on outcomes in larger systems. Indeed, their arbitrariness is why they have been used to infer causal relationships among variables in numerous settings. Regression discontinuity from econometrics assumes the existence of a discontinuous variable that splits the population into distinct partitions to estimate the causal effects of a given phenomenon. Here we consider the design of partitions for a…

通过条件分位数回归估计无条件分位数偏效应AI 解读

This paper develops a semi-parametric procedure for estimation of unconditional quantile partial effects using quantile regression coefficients. The estimator is based on an identification result showing that, for continuous covariates, unconditional quantile effects are a weighted average of conditional ones at particular quantile levels that depend on the covariates. We propose a two-step estimator for the unconditional effects where in the first step one estimates a…

干扰结构设定的随机化检验AI 解读

This study considers testing the specification of spillover effects in causal inference. We focus on experimental settings in which the treatment assignment mechanism is known to researchers. We develop a new randomization test utilizing a hierarchical relationship between different exposures. Compared with existing approaches, our approach is essentially applicable to any null exposure specifications and produces powerful test statistics without a priori knowledge of the…