每日简报

政策评估中因果机器学习的透明性挑战：可用性与问责AI 解读

Causal machine learning tools are beginning to see use in real-world policy evaluation tasks to flexibly estimate treatment effects. One issue with these methods is that the machine learning models used are generally black boxes, i.e., there is no globally interpretable way to understand how a model makes estimates. This is a clear problem in policy evaluation applications, particularly in government, because it is difficult to understand whether such models are functioning…

迈向因果基础模型：因果推断与注意力机制的对偶关系AI 解读

Foundation models have brought changes to the landscape of machine learning, demonstrating sparks of human-level intelligence across a diverse array of tasks. However, a gap persists in complex tasks such as causal inference, primarily due to challenges associated with intricate reasoning steps and high numerical precision requirements. In this work, we take a first step towards building causally-aware foundation models for treatment effect estimations. We propose a novel,…

考虑高维协变量复杂性的非线性内生处理效应推断AI 解读

Nonlinearity and endogeneity are prevalent challenges in causal analysis using observational data. This paper proposes an inference procedure for a nonlinear and endogenous marginal effect function, defined as the derivative of the nonparametric treatment function, with a primary focus on an additive model that includes high-dimensional covariates. Using the control function approach for identification, we implement a regularized nonparametric estimation to obtain an initial…

将双重差分研究的处理效应迁移至目标总体AI 解读

Difference-in-differences (DID) is a popular approach to identify the causal effects of treatments and policies in the presence of unmeasured confounding. DID identifies the sample average treatment effect in the treated (SATT). However, a goal of such research is often to inform decision-making in target populations outside the treated sample. Transportability methods have been developed to extend inferences from study samples to external target populations; these methods…

存在治疗中止的肿瘤随机试验中事件时间结局的因果效应评估AI 解读

In clinical trials, patients may discontinue treatments prematurely, breaking the initial randomization and, thus, challenging inference. Stakeholders in drug development are generally interested in going beyond the Intention-To-Treat (ITT) analysis, which provides valid causal estimates of the effect of treatment assignment but does not inform on the effect of the actual treatment receipt. Our study is motivated by an RCT in oncology, where patients assigned the…

检测阴性设计下评估新冠疫苗有效性的双重机器学习方法AI 解读

The test-negative design (TND), which is routinely used for monitoring seasonal flu vaccine effectiveness (VE), has recently become integral to COVID-19 vaccine surveillance, notably in Québec, Canada. Some studies have addressed the identifiability and estimation of causal parameters under the TND, but efficiency bounds for nonparametric estimators of the target parameter under the unconfoundedness assumption have not yet been investigated. Motivated by the goal of…

用于可解释异质性处理效应估计的因果规则学习新方法AI 解读

Interpretability plays a crucial role in the application of statistical learning to estimate heterogeneous treatment effects (HTE) in complex diseases. In this study, we leverage a rule-based workflow, namely causal rule learning (CRL), to estimate and improve our understanding of HTE for atrial septal defect, addressing an overlooked question in the previous literature: what if an individual simultaneously belongs to multiple groups with different average treatment effects?…

部分识别因果效应的模型无关协变量辅助推断AI 解读

Many causal estimands are only partially identifiable since they depend on the unobservable joint distribution between potential outcomes. Stratification on pretreatment covariates can yield sharper bounds; however, unless the covariates are discrete with relatively small support, this approach typically requires binning covariates or estimating the conditional distributions of potential outcomes given the covariates. Binning can result in substantial efficiency loss and…

比较两个生存函数多项特征的同时推断程序AI 解读

Survival time is the primary endpoint of many randomized controlled trials, and a treatment effect is typically quantified by the hazard ratio under the assumption of proportional hazards. Awareness is increasing that in many settings this assumption is a-priori violated, e.g. due to delayed onset of drug effect. In these cases, interpretation of the hazard ratio estimate is ambiguous and statistical inference for alternative parameters to quantify a treatment effect is…

网络成员身份误分类下自我中心网络随机试验的因果溢出效应推断AI 解读

To leverage peer influence and increase population behavioral changes, behavioral interventions often rely on peer-based strategies. A common study design that assesses such strategies is the egocentric-network randomized trial (ENRT), in which those receiving the intervention are encouraged to disseminate information to their peers. The Average Spillover Effect (ASpE) measures the impact of the intervention on participants who do not receive it, but whose outcomes may be…

完全随机化与计算机辅助平衡设计下的样本依从者平均因果效应推断AI 解读

Non-compliance is common in real world experiments. We focus on inference about the sample complier average causal effect, that is, the average treatment effect for experimental units who are compliers. We present three types of inference strategies for the sample complier average causal effect: the Wald estimator, regression adjustment estimators and model-based Bayesian inference. Because modern computer assisted experimental designs have been used to improve covariate…

生存分析中的时变中介：因果假设的图形表示AI 解读

We study time-dependent mediators in survival analysis using a treatment separation approach due to Didelez [2019] and based on earlier work by Robins and Richardson [2011]. This approach avoids nested counterfactuals and crossworld assumptions which are otherwise common in mediation analysis. The causal model of treatment, mediators, covariates, confounders and outcome is represented by causal directed acyclic graphs (DAGs). However, the DAGs tend to be very complex when we…

结构模型中的稳健最小距离推断AI 解读

This paper proposes minimum distance inference for a structural parameter of interest, which is robust to the lack of identification of other structural nuisance parameters. Some choices of the weighting matrix lead to asymptotic chi-squared distributions with degrees of freedom that can be consistently estimated from the data, even under partial identification. In any case, knowledge of the level of under-identification is not required. We study the power of our robust…

基线子组及相关分析的设计型随机试验估计量与中心极限定理AI 解读

There is a growing literature on design-based methods to estimate average treatment effects (ATEs) for randomized controlled trials (RCTs) for full sample analyses. This article extends these methods to estimate ATEs for discrete subgroups defined by pre-treatment variables, with an application to an RCT testing subgroup effects for a school voucher experiment in New York City. We consider ratio estimators for subgroup effects using regression methods, allowing for model…

最小假设下含协变量的断点回归平均处理效应估计AI 解读

We study regression discontinuity designs with the use of additional covariates for estimation of the average treatment effect. We provide a detailed proof of asymptotic normality of the covariate-adjusted estimator under minimal assumptions, which may serve as an accessible text to the mathematics behind regression discontinuity with covariates. In addition, this proof carries at least three benefits. First of all, it allows to draw straightforward consequences concerning…

参考组假设下纵向连续结局条件均值插补的序贯线性回归AI 解读

In clinical trials of longitudinal continuous outcomes, reference based imputation (RBI) has commonly been applied to handle missing outcome data in settings where the estimand incorporates the effects of intercurrent events, e.g. treatment discontinuation. RBI was originally developed in the multiple imputation framework, however recently conditional mean imputation (CMI) combined with the jackknife estimator of the standard error was proposed as a way to obtain…

错位实施双重差分中的机器学习与动态处理效应异质性AI 解读

We combine two recently proposed nonparametric difference-in-differences methods, extending them to enable the examination of treatment effect heterogeneity in the staggered adoption setting using machine learning. The proposed method, machine learning difference-in-differences (MLDID), allows for estimation of time-varying conditional average treatment effects on the treated, which can be used to conduct detailed inference on drivers of treatment effect heterogeneity. We…

反事实的保守推断AI 解读

In causal inference, the joint law of a set of counterfactual random variables is generally not identified. We show that a conservative version of the joint law - corresponding to the smallest treatment effect - is identified. Finding this law uses recent results from optimal transport theory. Under this conservative law we can bound causal effects and we may construct inferences for each individual's counterfactual dose-response curve. Intuitively, this is the flattest…

causalBETA：事件时间结局的贝叶斯半参数因果推断 R 包AI 解读

Observational studies are often conducted to estimate causal effects of treatments or exposures on event-time outcomes. Since treatments are not randomized in observational studies, techniques from causal inference are required to adjust for confounding. Bayesian approaches to causal estimates are desirable because they provide 1) prior smoothing provides useful regularization of causal effect estimates, 2) flexible models that are robust to misspecification, 3) full…

评分匹配下非线性模型因果发现的捷径AI 解读

The use of simulated data in the field of causal discovery is ubiquitous due to the scarcity of annotated real data. Recently, Reisach et al., 2021 highlighted the emergence of patterns in simulated linear data, which displays increasing marginal variance in the casual direction. As an ablation in their experiments, Montagna et al., 2023 found that similar patterns may emerge in nonlinear models for the variance of the score vector $\nabla \log p_{\mathbf{X}}$, and…

Rothman 图：流行病学因果推断的几何视角AI 解读

Here, we explain and illustrate a geometric perspective on causal inference in cohort studies that can help epidemiologists understand the role of standardization in causal inference as well as the distinctions between confounding, effect modification, and noncollapsibility. For simplicity, we focus on a binary exposure X, a binary outcome D, and a binary confounder C that is not causally affected by X. Rothman diagrams plot risk in the unexposed on the x-axis and risk in…

通过剥离算法实现广义线性模型的因果发现AI 解读

This article presents a novel method for causal discovery with generalized structural equation models suited for analyzing diverse types of outcomes, including discrete, continuous, and mixed data. Causal discovery often faces challenges due to unmeasured confounders that hinder the identification of causal relationships. The proposed approach addresses this issue by developing two peeling algorithms (bottom-up and top-down) to ascertain causal relationships and valid…

未观测分组异方差与固定效应AI 解读

This paper extends the linear grouped fixed effects (GFE) panel model to allow for heteroskedasticity from a discrete latent group variable. Key features of GFE are preserved, such as individuals belonging to one of a finite number of groups and group membership is unrestricted and estimated. Ignoring group heteroskedasticity may lead to poor classification, which is detrimental to finite sample bias and standard errors of estimators. I introduce the "weighted grouped fixed…

通过函数型生存分析刻画动态处理效应类型AI 解读

In recent years, research interest in personalised treatments has been growing. However, treatment effect heterogeneity and possibly time-varying treatment effects are still often overlooked in clinical studies. Statistical tools are needed for the identification of treatment response patterns, taking into account that treatment response is not constant over time. We aim to provide an innovative method to obtain dynamic treatment effect phenotypes on a time-to-event outcome,…