每日简报

结合外部观测数据识别与估计临床试验长期处理效应AI 解读

In biomedical studies, estimating drug effects on chronic diseases requires a long follow-up period, which is difficult to meet in randomized clinical trials (RCTs). The use of a short-term surrogate to replace the long-term outcome for assessing the drug effect relies on stringent assumptions that empirical studies often fail to satisfy. Motivated by a kidney disease study, we investigate the drug effects on long-term outcomes by combining an RCT without observation of…

理解异质性处理效应估计中的模型选择困境AI 解读

Personalized treatment effect estimates are often of interest in high-stakes applications -- thus, before deploying a model estimating such effects in practice, one needs to be sure that the best candidate from the ever-growing machine learning toolbox for this task was chosen. Unfortunately, due to the absence of counterfactual information in practice, it is usually not possible to rely on standard validation metrics for doing so, leading to a well-known model selection…

面板数据模型的高阶展开与推断AI 解读

In this paper, we propose a simple inferential method for a wide class of panel data models with a focus on such cases that have both serial correlation and cross-sectional dependence. In order to establish an asymptotic theory to support the inferential method, we develop some new and useful higher-order expansions, such as Berry-Esseen bound and Edgeworth Expansion, under a set of simple and general conditions. We further demonstrate the usefulness of these theoretical…

DeCAMFounder：隐藏变量下的非线性因果发现AI 解读

Many real-world decision-making tasks require learning causal relationships between a set of variables. Traditional causal discovery methods, however, require that all variables are observed, which is often not feasible in practical scenarios. Without additional assumptions about the unobserved variables, it is not possible to recover any causal relationships from observational data. Fortunately, in many applied settings, additional structure among the confounders can be…

没有显著星号是好消息：基于协变量平衡检验 p 值的再随机化AI 解读

Modern social and biomedical scientific publications require the reporting of covariate balance tables with not only covariate means by treatment group but also the associated $p$-values from significance tests of their differences. The practical need to avoid small $p$-values renders balance check and rerandomization by hypothesis testing standards an attractive tool for improving covariate balance in randomized experiments. Despite the intuitiveness of such practice and…

异质性处理效应的因果保序校准AI 解读

We propose causal isotonic calibration, a novel nonparametric method for calibrating predictors of heterogeneous treatment effects. Furthermore, we introduce cross-calibration, a data-efficient variant of calibration that eliminates the need for hold-out calibration sets. Cross-calibration leverages cross-fitted predictors and generates a single calibrated predictor using all available data. Under weak conditions that do not assume monotonicity, we establish that both causal…

条件分布局部线性回归估计的一致收敛结果AI 解读

This paper examines the local linear regression (LLR) estimate of the conditional distribution function $F(y|x)$. We derive three uniform convergence results: the uniform bias expansion, the uniform convergence rate, and the uniform asymptotic linear representation. The uniformity in the above results is with respect to both $x$ and $y$ and therefore has not previously been addressed in the literature on local polynomial regression. Such uniform convergence results are…

将处理效应推广和迁移至目标总体的一步加权AI 解读

The problem of generalization and transportation of treatment effect estimates from a study sample to a target population is central to empirical research and statistical methodology. In both randomized experiments and observational studies, weighting methods are often used with this objective. Traditional methods construct the weights by separately modeling the treatment assignment and study selection probabilities and then multiplying functions (e.g., inverses) of their…

用于干预后密度估计的归一化流AI 解读

Existing machine learning methods for causal inference usually estimate quantities expressed via the mean of potential outcomes (e.g., average treatment effect). However, such quantities do not capture the full information about the distribution of potential outcomes. In this work, we estimate the density of potential outcomes after interventions from observational data. For this, we propose a novel, fully-parametric deep learning method called Interventional Normalizing…

RobustIV 与 controlfunctionIV：可能无效工具变量下的因果推断软件AI 解读

We present R software packages RobustIV and controlfunctionIV for causal inference with possibly invalid instrumental variables. RobustIV focuses on the linear outcome model. It implements the two-stage hard thresholding method to select valid instrumental variables from a set of candidate instrumental variables and make inferences for the causal effect in both low- and high-dimensional settings. Furthermore, RobustIV implements the high-dimensional endogeneity test and the…

异质因果图中的异质性处理效应AI 解读

Heterogeneity and comorbidity are two interwoven challenges associated with various healthcare problems that greatly hampered research on developing effective treatment and understanding of the underlying neurobiological mechanism. Very few studies have been conducted to investigate heterogeneous causal effects (HCEs) in graphical contexts due to the lack of statistical methods. To characterize this heterogeneity, we first conceptualize heterogeneous causal graphs (HCGs) by…

存在网络溢出的线性成对数据模型推断AI 解读

When using dyadic data (i.e., data indexed by pairs of units), researchers typically assume a linear model, estimate it using Ordinary Least Squares and conduct inference using ``dyadic-robust" variance estimators. The latter assumes that dyads are uncorrelated if they do not share a common unit (e.g., if the same individual is not present in both pairs of data). We show that this assumption does not hold in many empirical applications because indirect links may exist due to…

用于因果推断的变量重要性匹配AI 解读

Our goal is to produce methods for observational causal inference that are auditable, easy to troubleshoot, accurate for treatment effect estimation, and scalable to high-dimensional data. We describe a general framework called Model-to-Match that achieves these goals by (i) learning a distance metric via outcome modeling, (ii) creating matched groups using the distance metric, and (iii) using the matched groups to estimate treatment effects. Model-to-Match uses variable…

可微分的多目标因果贝叶斯实验设计AI 解读

We introduce a gradient-based approach for the problem of Bayesian optimal experimental design to learn causal models in a batch setting -- a critical component for causal discovery from finite data where interventions can be costly or risky. Existing methods rely on greedy approximations to construct a batch of experiments while using black-box methods to optimize over a single target-state pair to intervene with. In this work, we completely dispose of the black-box…

用于工具变量回归的深度偏最小二乘法AI 解读

In this paper, we propose deep partial least squares for the estimation of high-dimensional nonlinear instrumental variable regression. As a precursor to a flexible deep neural network architecture, our methodology uses partial least squares for dimension reduction and feature selection from the set of instruments and covariates. A central theoretical result, due to Brillinger (2012) shows that the feature selection provided by partial least squares is consistent and the…

面板正态有限混合回归模型的成分数量检验AI 解读

This paper develops the likelihood ratio-based test of the null hypothesis of a M0-component model against an alternative of (M0 + 1)-component model in the normal mixture panel regression by extending the Expectation-Maximization (EM) test of Chen and Li (2009a) and Kasahara and Shimotsu (2015) to the case of panel data. We show that, unlike the cross-sectional normal mixture, the first-order derivative of the density function for the variance parameter in the panel normal…

模糊动态治疗方案：强化学习方法AI 解读

A main research goal in various studies is to use an observational data set and provide a new set of counterfactual guidelines that can yield causal improvements. Dynamic Treatment Regimes (DTRs) are widely studied to formalize this process. However, available methods in finding optimal DTRs often rely on assumptions that are violated in real-world applications (e.g., medical decision-making or public policy), especially when (a) the existence of unobserved confounders…

个体处理效应估计的迁移学习AI 解读

This work considers the problem of transferring causal knowledge between tasks for Individual Treatment Effect (ITE) estimation. To this end, we theoretically assess the feasibility of transferring ITE knowledge and present a practical framework for efficient transfer. A lower bound is introduced on the ITE error of the target task to demonstrate that ITE knowledge transfer is challenging due to the absence of counterfactual information. Nevertheless, we establish…

结合支持集不重叠的观察数据与实验数据估计处理效应AI 解读

When estimating treatment effects, the golden standard is to conduct a randomized experiment and then contrast outcomes associated with the treatment group and the control group. However, in many cases, randomized experiments are either conducted with a much smaller scale compared to the size of the target population or accompanied with certain ethical issues and thus hard to implement. Therefore, researchers usually rely on observational data to study causal connections.…

预算约束下的 PAC-Bayes 处理分配AI 解读

This paper considers the estimation of treatment assignment rules when the policy maker faces a general budget or resource constraint. Utilizing the PAC-Bayesian framework, we propose new treatment assignment rules that allow for flexible notions of treatment outcome, treatment cost, and a budget constraint. For example, the constraint setting allows for cost-savings, when the costs of non-treatment exceed those of treatment for a subpopulation, to be factored into the…

隐藏混杂下剂量响应的部分识别AI 解读

Inferring causal effects of continuous-valued treatments from observational data is a crucial task promising to better inform policy- and decision-makers. A critical assumption needed to identify these effects is that all confounding variables -- causal parents of both the treatment and the outcome -- are included as covariates. Unfortunately, given observational data alone, we cannot know with certainty that this criterion is satisfied. Sensitivity analyses provide…

有限个聚类下分位数过程的推断AI 解读

I introduce a generic method for inference on entire quantile and regression quantile processes in the presence of a finite number of large and arbitrarily heterogeneous clusters. The method asymptotically controls size by generating statistics that exhibit enough distributional symmetry such that randomization tests can be applied. The randomization test does not require ex-ante matching of clusters, is free of user-chosen parameters, and performs well at conventional…

用于右删失配对生存结局直接比较的非参数相对治疗效应AI 解读

A very classical problem in statistics is to test the stochastic superiority of one distribution to another. However, many existing approaches are developed for independent samples and, moreover, do not take censored data into account. We develop a new estimand-driven method to compare the effectiveness of two treatments in the context of right-censored survival data with matched pairs. With the help of competing risks techniques, the so-called relative treatment effect is…

基于二维得分的异质性处理效应估计AI 解读

Statisticians show growing interest in estimating and analyzing heterogeneity in causal effects in observational studies. However, there usually exists a trade-off between accuracy and interpretability for developing a desirable estimator for treatment effects, especially in the case when there are a large number of features in estimation. To make efforts to address the issue, we propose a score-based framework for estimating the Conditional Average Treatment Effect (CATE)…