Assessing treatment effect heterogeneity in the presence of missing effect modifier data in cluster-randomized trials
整群随机试验中效应修饰变量缺失时的治疗效应异质性评估
Understanding whether and how treatment effects vary across subgroups is crucial to inform clinical practice and recommendations. Accordingly, the assessment of heterogeneous treatment effects (HTE) based on pre-specified potential effect modifiers has become a common goal in modern randomized trials. However, when one or more potential effect modifiers are missing, complete-case analysis may lead to bias and under-coverage. While statistical methods for handling missing…