每日简报

通过分布插补开展纵向临床试验敏感性分析AI 解读

Missing data is inevitable in longitudinal clinical trials. Conventionally, the missing at random assumption is assumed to handle missingness, which however is unverifiable empirically. Thus, sensitivity analysis is critically important to assess the robustness of the study conclusions against untestable assumptions. Toward this end, regulatory agencies often request using imputation models such as return-to-baseline, control-based, and washout imputation. Multiple…

TreatmentEstimatoR：观测健康数据处理效应估计仪表板AI 解读

Observational health data can be leveraged to measure the real-world use and potential benefits or risks of existing medical interventions. However, lack of programming proficiency and advanced knowledge of causal inference methods excludes some clinicians and non-computational researchers from performing such analyses. Code-free dashboard tools provide accessible means to estimate and visualize treatment effects from observational health data. We present TreatmentEstimatoR,…

基于功效分析改进存在干扰时的随机化检验AI 解读

In causal inference, we can consider a situation in which treatment on one unit affects others, i.e., interference exists. In the presence of interference, we cannot perform a classical randomization test directly because a null hypothesis is not sharp. Instead, we need to perform the randomization test restricted to a subset of units and assignments that makes the null hypothesis sharp. A previous study constructed a useful testing method, a biclique test, by reducing the…

缺失且非正态连续结局的纵向临床试验稳健分析AI 解读

Missing data is unavoidable in longitudinal clinical trials, and outcomes are not always normally distributed. In the presence of outliers or heavy-tailed distributions, the conventional multiple imputation with the mixed model with repeated measures analysis of the average treatment effect (ATE) based on the multivariate normal assumption may produce bias and power loss. Control-based imputation (CBI) is an approach for evaluating the treatment effect under the assumption…

多变量时间序列中的潜在因果关系学习AI 解读

Identifying the causal structure of systems with multiple dynamic elements is critical to several scientific disciplines. The conventional approach is to conduct statistical tests of causality, for example with Granger Causality, between observed signals that are selected a priori. Here it is posited that, in many systems, the causal relations are embedded in a latent space that is expressed in the observed data as a linear mixture. A technique for blindly identifying the…

混杂调整的贝叶斯非参数方法AI 解读

Analysis of observational studies increasingly confronts the challenge of determining which of a possibly high-dimensional set of available covariates are required to satisfy the assumption of ignorable treatment assignment for estimation of causal effects. We propose a Bayesian nonparametric approach that simultaneously 1) prioritizes inclusion of adjustment variables in accordance with existing principles of confounder selection; 2) estimates causal effects in a manner…

Exabel 波动率估计方法的表现评价AI 解读

Quantifying both historic and future volatility is key in portfolio risk management. This note presents and compares estimation strategies for volatility estimation in an estimation universe consisting on 28 629 unique companies from February 2010 to April 2021, with 858 different portfolios. The estimation methods are compared in terms of how they rank the volatility of the different subsets of portfolios. The overall best performing approach estimates volatility from…

Exabel 的因子模型AI 解读

Factor models have become a common and valued tool for understanding the risks associated with an investing strategy. In this report we describe Exabel's factor model, we quantify the fraction of the variability of the returns explained by the different factors, and we show some examples of annual returns of portfolios with different factor exposure.

线性计量模型中偏误调整处理效应的界集AI 解读

In linear econometric models with proportional selection on unobservables, omitted variable bias in estimated treatment effects are real roots of a cubic equation involving estimated parameters from a short and intermediate regression. The roots of the cubic are functions of $δ$, the degree of selection on unobservables, and $R_{max}$, the R-squared in a hypothetical long regression that includes the unobservable confounder and all observable controls. In this paper I…

球面自回归模型及其在分布与成分时间序列中的应用AI 解读

We introduce a new class of autoregressive models for spherical time series, where the dimension of the spheres on which the observations of the time series are situated may be finite-dimensional or infinite-dimensional as in the case of a general Hilbert sphere. Spherical time series arise in various settings. We focus here on distributional and compositional time series. Applying a square root transformation to the densities of the observations of a distributional time…

随机矩阵时间序列AI 解读

In this paper, a time series model with coefficients that take values from random matrix ensembles is proposed. Formal definitions, theoretical solutions, and statistical properties are derived. Estimation and forecast methodologies for random matrix time series are discussed with examples. Random matrix differential equations and potential applications of the time series model are suggested at the end.

大维广义因子模型中的因子个数确定AI 解读

This paper proposes new estimators of the number of factors for a generalised factor model with more relaxed assumptions than the strict factor model. Under the framework of large cross-sections $N$ and large time dimensions $T$, we first derive the bias-corrected estimator $\hat σ^2_*$ of the noise variance in a generalised factor model by random matrix theory. Then we construct three information criteria based on $\hat σ^2_*$, further propose the consistent estimators of…

将整群随机试验的因果推断推广至目标总体AI 解读

We describe methods that extend (generalize or transport) causal inferences from cluster randomized trials to a target population of clusters, under a general nonparametric model that allows for arbitrary within-cluster dependence. We propose doubly robust estimators of potential outcome means in the target population that exploit individual-level data on covariates and outcomes to improve efficiency and are appropriate for use with machine learning methods. We illustrate…

时变中介、处理与混杂下的高效灵活因果中介分析AI 解读

Interventional effects have been proposed as a solution to the unidentifiability of natural (in)direct effects under mediator-outcome confounders affected by the exposure. Such confounders are an intrinsic characteristic of studies with time-varying exposures and mediators, yet the generalization of the interventional effect framework to the time-varying case has received little attention in the literature. We present an identification result for interventional effects in a…

基于 SURE 的稳健信号维度估计AI 解读

The estimation of signal dimension under heavy-tailed latent factor models is studied. As a primary contribution, robust extensions of an earlier estimator based on Gaussian Stein's unbiased risk estimation are proposed. These novel extensions are based on the framework of elliptical distributions and robust scatter matrices. Extensive simulation studies are conducted in order to compare the novel methods with several well-known competitors in both estimation accuracy and…

用于不规则观测离散时间序列的新型一阶自回归移动平均模型AI 解读

A novel first-order autoregressive moving average model for analyzing discrete-time series observed at irregularly spaced times is introduced. Under Gaussianity, it is established that the model is strictly stationary and ergodic. In the general case, it is shown that the model is weakly stationary. The lowest dimension of the state-space representation is given along with the one-step linear predictors and their mean squared errors. The maximum likelihood estimation…

非线性固定效应面板模型的间接推断AI 解读

Fixed effect estimators of nonlinear panel data models suffer from the incidental parameter problem. This leads to two undesirable consequences in applied research: (1) point estimates are subject to large biases, and (2) confidence intervals have incorrect coverages. This paper proposes a simulation-based method for bias reduction. The method simulates data using the model with estimated individual effects, and finds values of parameters by equating fixed effect estimates…

利用条件独立性预先指定结构，优化数据收集与研究透明度AI 解读

Data collection and research methodology represents a critical part of the research pipeline. On the one hand, it is important that we collect data in a way that maximises the validity of what we are measuring, which may involve the use of long scales with many items. On the other hand, collecting a large number of items across multiple scales results in participant fatigue, and expensive and time consuming data collection. It is therefore important that we use the available…

因果推断稀疏方法的信息准则AI 解读

For propensity score analysis and sparse estimation, we develop an information criterion for determining the regularization parameters needed in variable selection. First, for Gaussian distribution-based causal inference models, we extend Stein's unbiased risk estimation theory, which leads to a generalized Cp criterion that has almost no weakness in conventional sparse estimation, and derive an inverse-probability-weighted sparse estimation version of the criterion without…

Cox比例风险模型变点检测的信息准则AI 解读

The Cox proportional hazards model, commonly used in clinical trials, assumes proportional hazards. However, it does not hold when, for example, there is a delayed onset of the treatment effect. In such a situation, an acute change in the hazard ratio function is expected to exist. This paper considers the Cox model with change-points and derives AIC-type information criteria for detecting those change-points. The change-point model does not allow for conventional…

利用变分高斯过程推断非线性动力系统的简约耦合统计量AI 解读

Falsification is the basis for testing existing hypotheses, and a great danger is posed when results incorrectly reject our prior notions (false positives). Though nonparametric and nonlinear exploratory methods of uncovering coupling provide a flexible framework to study network configurations and discover causal graphs, multiple comparisons analyses make false positives more likely, exacerbating the need for their control. We aim to robustify the Gaussian Processes…

正变量随机和时间序列的自回归模型：气候与虫害下的树木生长应用AI 解读

We present a broad class of semi-parametric models for time series of random sums of positive variables. Our methodology allows the number of terms inside the sum to be time-varying and is therefore well suited to many examples encountered in the natural sciences. We study the stability properties of the models and provide a valid statistical inference procedure to estimate the model parameters. It is shown that the proposed quasi-maximum likelihood estimator is consistent…

专家第二意见的反事实推断AI 解读

Automated decision support systems that are able to infer second opinions from experts can potentially facilitate a more efficient allocation of resources; they can help decide when and from whom to seek a second opinion. In this paper, we look at the design of this type of support systems from the perspective of counterfactual inference. We focus on a multiclass classification setting and first show that, if experts make predictions on their own, the underlying causal…

结合内部与外部对照对临床试验处理效应进行双重检验AI 解读

Leveraging external controls -- relevant individual patient data under control from external trials or real-world data -- has the potential to reduce the cost of randomized controlled trials (RCTs) while increasing the proportion of trial patients given access to novel treatments. However, due to lack of randomization, RCT patients and external controls may differ with respect to covariates that may or may not have been measured. Hence, after controlling for measured…