每日简报

双重稳健泛函的极小极大核学习及近端因果推断应用AI 解读

Robins et al. (2008) introduced a class of influence functions (IFs) which could be used to obtain doubly robust moment functions for the corresponding parameters. However, that class does not include the IF of parameters for which the nuisance functions are solutions to integral equations. Such parameters are particularly important in the field of causal inference, specifically in the recently proposed proximal causal inference framework of Tchetgen Tchetgen et al. (2020),…

局部因果结构学习的快速非参数方法AI 解读

We study the problem of causal structure learning with essentially no assumptions on the functional relationships and noise. We develop DAG-FOCI, a computationally fast algorithm for this setting that is based on the FOCI variable selection algorithm in~\cite{azadkia2021simple}. DAG-FOCI outputs the set of parents of a response variable of interest. We provide theoretical guarantees of our procedure when the underlying graph does not contain any (undirected) cycle containing…

随机与观测研究中因果风险率比的敏感性分析AI 解读

The Hazard Ratio (HR) is often reported as the main causal effect when studying survival data. Despite its popularity, the HR suffers from an unclear causal interpretation. As already pointed out in the literature, there is a built-in selection bias in the HR, because similarly to the truncation by death problem, the HR conditions on post-treatment survival. A recently proposed alternative, inspired by the Survivor Average Causal Effect (SACE), is the causal HR, defined as…

给定处理后中间响应的主分层因果效应识别AI 解读

In neoadjuvant trials on early-stage breast cancer, patients are usually randomized into a control group and a treatment group with an additional target therapy. Early efficacy of the new regimen is assessed via the binary pathological complete response (pCR) and the eventual efficacy is assessed via long-term clinical outcomes such as survival. Although pCR is strongly associated with survival, it has not been confirmed as a surrogate endpoint. To fully understand its…

后验预测倾向得分与 p 值AI 解读

\citet{Rosenbaum83ps} introduced the notion of the propensity score and discussed its central role in causal inference with observational studies. Their paper, however, caused a fundamental incoherence with an early paper by \citet{Rubin78}, which showed that the propensity score does not play any role in the Bayesian analysis of unconfounded observational studies if the priors on the propensity score and outcome models are independent. Despite the serious efforts made in…

用于因果发现的最优传输方法AI 解读

To determine causal relationships between two variables, approaches based on Functional Causal Models (FCMs) have been proposed by properly restricting model classes; however, the performance is sensitive to the model assumptions, which makes it difficult to use. In this paper, we provide a novel dynamical-system view of FCMs and propose a new framework for identifying causal direction in the bivariate case. We first show the connection between FCMs and optimal transport,…

稀疏加权时变网络的得分驱动广义适应度模型AI 解读

While the vast majority of the literature on models for temporal networks focuses on binary graphs, often one can associate a weight to each link. In such cases the data are better described by a weighted, or valued, network. An important well known fact is that real world weighted networks are typically sparse. We propose a novel time varying parameter model for sparse and weighted temporal networks as a combination of the fitness model, appropriately extended, and the…

利用分位点局部多项式决策树与森林建模异质性处理效应AI 解读

To further develop the statistical inference problem for heterogeneous treatment effects, this paper builds on Breiman's (2001) random forest tree (RFT)and Wager et al.'s (2018) causal tree to parameterize the nonparametric problem using the excellent statistical properties of classical OLS and the division of local linear intervals based on covariate quantile points, while preserving the random forest trees with the advantages of constructible confidence intervals and…

个性化补贴规则AI 解读

Subsidies are commonly used to encourage behaviors that can lead to short- or long-term benefits. Typical examples include subsidized job training programs and provisions of preventive health products, in which both behavioral responses and associated gains can exhibit heterogeneity. This study uses the marginal treatment effect (MTE) framework to study personalized assignments of subsidies based on individual characteristics. First, we derive the optimality condition for a…

标准与参照组条件均值插补AI 解读

Clinical trials with longitudinal outcomes typically include missing data due to missed assessments or structural missingness of outcomes after intercurrent events handled with a hypothetical strategy. Approaches based on Bayesian random multiple imputation and Rubin's rule for pooling results across multiple imputed datasets are increasingly used in order to align the analysis of these trials with the targeted estimand. We propose and justify deterministic conditional mean…