每日简报

利用多变量孟德尔随机化分离共享聚集遗传预测因子的性状效应AI 解读

When genetic variants in a gene cluster are associated with a disease outcome, the causal pathway from the variants to the outcome can be difficult to disentangle. For example, the chemokine receptor gene cluster contains genetic variants associated with various cytokines. Associations between variants in this cluster and stroke risk may be driven by any of these cytokines. Multivariable Mendelian randomization is an extension of standard univariable Mendelian randomization…

处理时点变化下双重差分与比较中断时间序列设计的统计功效AI 解读

This article develops new closed-form variance expressions for power analyses for commonly used difference-in-differences (DID) and comparative interrupted time series (CITS) panel data estimators. The main contribution is to incorporate variation in treatment timing into the analysis. The power formulas also account for other key design features that arise in practice: autocorrelated errors, unequal measurement intervals, and clustering due to the unit of treatment…

不保留个体数据的随机对照试验AI 解读

Amidst rising appreciation for privacy and data usage rights, researchers have increasingly acknowledged the principle of data minimization, which holds that the accessibility, collection, and retention of subjects' data should be kept to the bare amount needed to answer focused research questions. Applying this principle to randomized controlled trials (RCTs), this paper presents algorithms for making accurate inferences from RCTs under stringent data retention and…

协调裂区试验中的设计型与模型型因果推断AI 解读

The split-plot design assigns different interventions at the whole-plot and sub-plot levels, respectively, and induces a group structure on the final treatment assignments. A common strategy is to use the OLS fit of the outcome on the treatment indicators coupled with the robust standard errors clustered at the whole-plot level. It does not give consistent estimator for the causal effects of interest when the whole-plot sizes vary. Another common strategy is to fit the…

最优动态治疗规则价值估计量的表现与应用AI 解读

Given an (optimal) dynamic treatment rule, it may be of interest to evaluate that rule -- that is, to ask the causal question: what is the expected outcome had every subject received treatment according to that rule? In this paper, we study the performance of estimators that approximate the true value of: 1) an $a$ $priori$ known dynamic treatment rule 2) the true, unknown optimal dynamic treatment rule (ODTR); 3) an estimated ODTR, a so-called "data-adaptive parameter,"…

通过选择观测内容高效在线估计因果效应AI 解读

Researchers often face data fusion problems, where multiple data sources are available, each capturing a distinct subset of variables. While problem formulations typically take the data as given, in practice, data acquisition can be an ongoing process. In this paper, we aim to estimate any functional of a probabilistic model (e.g., a causal effect) as efficiently as possible, by deciding, at each time, which data source to query. We propose online moment selection (OMS), a…