每日简报

清晰与模糊断点及折点设计中的层级高斯过程模型AI 解读

We propose nonparametric Bayesian estimators for causal inference exploiting Regression Discontinuity/Kink (RD/RK) under sharp and fuzzy designs. Our estimators are based on Gaussian Process (GP) regression and classification. The GP methods are powerful probabilistic machine learning approaches that are advantageous in terms of derivative estimation and uncertainty quantification, facilitating RK estimation and inference of RD/RK models. These estimators are extended to…

具有高维协变量的断点回归设计推断AI 解读

We study regression discontinuity designs in which many predetermined covariates, possibly much more than the number of observations, can be used to increase the precision of treatment effect estimates. We consider a two-step estimator which first selects a small number of "important" covariates through a localized Lasso-type procedure, and then, in a second step, estimates the treatment effect by including the selected covariates linearly into the usual local linear…

多层级研究中更高效的双重稳健非参数处理效应估计量AI 解读

When studying treatment effects in multilevel studies, investigators commonly use (semi-)parametric estimators, which make strong parametric assumptions about the outcome, the treatment, and/or the correlation structure between study units in a cluster. We propose a novel estimator of treatment effects that does not make such assumptions. Specifically, the new estimator is shown to be doubly robust, asymptotically Normal, and often more efficient than existing estimators,…

先验强化信息准则AI 解读

The widely applicable information criterion (WAIC) has been used as a model selection criterion for Bayesian statistics in recent years. It is an asymptotically unbiased estimator of the Kullback-Leibler divergence between a Bayesian predictive distribution and the true distribution. Not only is the WAIC theoretically more sound than other information criteria, its usefulness in practice has also been reported. On the other hand, the WAIC is intended for settings in which…

随机对照试验协变量平衡方法的对抗鲁棒性局限AI 解读

The first step towards investigating the effectiveness of a treatment via a randomized trial is to split the population into control and treatment groups then compare the average response of the treatment group receiving the treatment to the control group receiving the placebo. In order to ensure that the difference between the two groups is caused only by the treatment, it is crucial that the control and the treatment groups have similar statistics. Indeed, the validity and…

结合基尼系数与角度衡量经济离散程度AI 解读

Classical measures of inequality use the mean as the benchmark of economic dispersion. They are not sensitive to inequality at the left tail of the distribution, where it would matter most. This paper presents a new inequality measurement tool that gives more weight to inequality at the lower end of the distribution, it is based on the comparison of all value pairs and synthesizes the dispersion of the whole distribution. The differences that sum to the Gini coefficient are…

死亡截断问题的匹配方法AI 解读

Even in a carefully designed randomized trial, outcomes for some study participants can be missing, or more precisely, ill-defined, because participants had died prior to date of outcome collection. This problem, known as truncation by death, means that the treated and untreated are no longer balanced with respect to covariates determining survival. Therefore, researchers often utilize principal stratification and focus on the Survivor Average Causal Effect (SACE). The SACE…

因果推断中的双重稳健模型选择准则AI 解读

The semiparametric estimation approach, which includes inverse-probability-weighted and doubly robust estimation using propensity scores, is a standard tool in causal inference, and it is rapidly being extended in various directions. On the other hand, although model selection is indispensable in statistical analysis, an information criterion for selecting an appropriate regression structure has just started to be developed. In this paper, based on the original definition of…

近端强化学习：部分可观测马尔可夫决策过程中的高效离策略评估AI 解读

In applications of offline reinforcement learning to observational data, such as in healthcare or education, a general concern is that observed actions might be affected by unobserved factors, inducing confounding and biasing estimates derived under the assumption of a perfect Markov decision process (MDP) model. Here we tackle this by considering off-policy evaluation in a partially observed MDP (POMDP). Specifically, we consider estimating the value of a given target…

离散工具变量与处理误报下边际处理效应的部分识别AI 解读

This paper provides partial identification results for the marginal treatment effect ($MTE$) when the binary treatment variable is potentially misreported and the instrumental variable is discrete. Identification results are derived under different sets of nonparametric assumptions. The identification results are illustrated in identifying the marginal treatment effects of food stamps on health.

基于二维得分的异质性处理效应估计AI 解读

Statisticians show growing interest in estimating and analyzing heterogeneity in causal effects in observational studies. However, there usually exists a trade-off between accuracy and interpretability for developing a desirable estimator for treatment effects, especially in the case when there are a large number of features in estimation. To make efforts to address the issue, we propose a score-based framework for estimating the Conditional Average Treatment Effect (CATE)…

重尾分布极端分位数处理效应的估计与推断AI 解读

Causal inference for extreme events has many potential applications in fields such as climate science, medicine and economics. We study the extremal quantile treatment effect of a binary treatment on a continuous, heavy-tailed outcome. Existing methods are limited to the case where the quantile of interest is within the range of the observations. For applications in risk assessment, however, the most relevant cases relate to extremal quantiles that go beyond the data range.…

改进重复测量混合模型以稳健提高随机试验精度AI 解读

In randomized trials, repeated measures of the outcome are routinely collected. The mixed model for repeated measures (MMRM) leverages the information from these repeated outcome measures, and is often used for the primary analysis to estimate the average treatment effect at the primary endpoint. MMRM, however, can suffer from bias and precision loss when it models intermediate outcomes incorrectly, and hence fails to use the post-randomization information harmlessly. This…

因果推断中的深度学习入门AI 解读

This review systematizes the emerging literature for causal inference using deep neural networks under the potential outcomes framework. It provides an intuitive introduction on how deep learning can be used to estimate/predict heterogeneous treatment effects and extend causal inference to settings where confounding is non-linear, time varying, or encoded in text, networks, and images. To maximize accessibility, we also introduce prerequisite concepts from causal inference…

利用大规模倾向得分调整间接测量的混杂AI 解读

Confounding remains one of the major challenges to causal inference with observational data. This problem is paramount in medicine, where we would like to answer causal questions from large observational datasets like electronic health records (EHRs) and administrative claims. Modern medical data typically contain tens of thousands of covariates. Such a large set carries hope that many of the confounders are directly measured, and further hope that others are indirectly…

断点回归设计中的协变量调整AI 解读

The Regression Discontinuity (RD) design is a widely used non-experimental method for causal inference and program evaluation. While its canonical formulation only requires a score and an outcome variable, it is common in empirical work to encounter RD analyses where additional variables are used for adjustment. This practice has led to misconceptions about the role of covariate adjustment in RD analysis, from both methodological and empirical perspectives. In this chapter,…

Motivation: Mediation analysis is an important tool for elucidating causal mechanisms in biomedical research and has recently gained increasing attention in microbiome studies. Motivated by a microbiome study of acute myeloid leukemia (AML) patients, we investigate whether the effect of induction chemotherapy intensity on infection status is mediated through gut microbial taxa. This problem poses substantial methodological challenges due to the high dimensionality, zero…

时变内生随机系数面板模型的识别与估计AI 解读

This paper proposes a correlated random coefficient linear panel data model, where regressors can be correlated with time-varying and individual-specific random coefficients through both a fixed effect and a time-varying random shock. I develop a new panel data-based method to identify the average partial effect and the local average response function. The identification strategy employs a sufficient statistic to control for the fixed effect and a control variable for the…

CIMTx：利用观测数据进行多处理因果推断的 R 包AI 解读

CIMTx provides efficient and unified functions to implement modern methods for causal inferences with multiple treatments using observational data with a focus on binary outcomes. The methods include regression adjustment, inverse probability of treatment weighting, Bayesian additive regression trees, regression adjustment with multivariate spline of the generalized propensity score, vector matching and targeted maximum likelihood estimation. In addition, CIMTx illustrates…

效应异质性还是处理异质性？聚合与细分处理的政策评估AI 解读

Binary treatments are often ex-post aggregates of multiple treatments or can be disaggregated into multiple treatment versions. Thus, effects can be heterogeneous due to either effect or treatment heterogeneity. We propose a decomposition method that uncovers masked heterogeneity, avoids spurious discoveries, and evaluates treatment assignment quality. The estimation and inference procedure based on double/debiased machine learning allows for high-dimensional confounding,…

通过迭代凸优化估计高维单调指数模型AI 解读

In this paper we propose new approaches to estimating large dimensional monotone index models. This class of models has been popular in the applied and theoretical econometrics literatures as it includes discrete choice, nonparametric transformation, and duration models. A main advantage of our approach is computational. For instance, rank estimation procedures such as those proposed in Han (1987) and Cavanagh and Sherman (1998) that optimize a nonsmooth, non convex…

大量弱工具变量下的统计推断AI 解读

We develop a concept of weak identification in linear IV models in which the number of instruments can grow at the same rate or slower than the sample size. We propose a jackknifed version of the classical weak identification-robust Anderson-Rubin (AR) test statistic. Large-sample inference based on the jackknifed AR is valid under heteroscedasticity and weak identification. The feasible version of this statistic uses a novel variance estimator. The test has uniformly…

通过局部图学习因果结构AI 解读

We consider the problem of learning causal structures in sparse high-dimensional settings that may be subject to the presence of (potentially many) unmeasured confounders, as well as selection bias. Based on the structure found in common families of large random networks and examining the representation of local structures in linear structural equation models (SEM), we propose a new local notion of sparsity for consistent structure learning in the presence of latent and…

厘清整群随机试验的选择偏差：目标参数与估计AI 解读

In cluster randomized trials, patients are typically recruited after clusters are randomized, and the recruiters and patients may not be blinded to the assignment. This often leads to differential recruitment and consequently systematic differences in baseline characteristics of the recruited patients between intervention and control arms, inducing post-randomization selection bias. We rigorously define causal estimands in the presence of selection bias. We elucidate the…