Estimation of time-specific intervention effects on continuously distributed time-to-event outcomes by targeted maximum likelihood estimation
连续事件时间结局中特定时点干预效应的目标最大似然估计
Targeted maximum likelihood estimation is a general methodology combining flexible ensemble learning and semiparametric efficiency theory in a two-step procedure for estimation of causal parameters. Proposed targeted maximum likelihood procedures for survival and competing risks analysis have so far focused on events taken values in discrete time. We here present a targeted maximum likelihood estimation procedure for event times that take values in R+. We focuson the…