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协变量依赖删失下半竞争风险数据的双重稳健估计AI 解读

Semi-competing risks occur when individuals may experience a non-terminal event and a terminal event, where the terminal event censors the non-terminal event but not vice versa. In the presence of covariate-dependent censoring, augmented inverse probability of censoring weighting (AIPCW) framework has not been developed for the special setting of semi-competing risks which, unlike competing risks, have asymmetric event time structure and complex estimands. Using…

线性模型中的最优检验及其因果推断含义AI 解读

Despite its widespread use in practice, multiple regression suffers from two important limitations due to ignoring the structure between predictors. First, reported coefficients are, in fact, direct effects in a causal context. These are often less meaningful than total effects when accounting for a factor's contribution, however, estimating the latter typically requires a causal diagram to be specified among predictors. The second limitation is multicollinearity, which…

目标试验模拟中有效统计推断的样本分割方法AI 解读

\noindent Target trial emulation has improved comparative effectiveness research by making the causal question, assumptions, and analysis plan explicit. However, target trial protocols are usually developed iteratively. That is, after examining the data, investigators revise the protocol to reflect which target trials the observational data can realistically support. This iterative procedure is part of normal scientific practice, but it raises concerns about selective…