Heterogeneous survivor average causal effects beyond monotonicity: Applications to a clinical trial evaluating mechanical ventilation strategies
超越单调性的异质幸存者平均因果效应:机械通气临床试验应用
Clinical trials in critical care often evaluate outcomes that are truncated by death, such as time to discharge alive, for which treatment effects are not well defined among patients who would not survive under one or both treatment strategies. Principal stratification provides a natural framework for defining survivor causal effects, but existing approaches often rely on monotonicity assumptions that may be implausible in settings where treatment can affect survival in…