每日简报

非可分面板数据模型中结构与因果效应的线性估计AI 解读

This paper develops linear estimators for structural and causal parameters of nonseparable models using panel data. These models incorporate unobserved, time-varying, individual heterogeneity, which may be correlated with the regressors. Estimation is based on an approximation of a conditional average potential outcome by a linear sieve specification with individual-specific parameters. Effects of interest are estimated by a bias corrected average of individual ridge…

监管试验协变量调整的良好实践：从固定到数据自适应方法AI 解读

While randomization justifies the use of unadjusted effect estimators in randomized trials, there is growing interest in covariate adjustment to improve precision. Adjusting for baseline variables that are prognostic of the outcome can reduce estimator variance, resulting in narrower confidence intervals and increased statistical power. Recent guidance by the U.S. Food and Drug Administration supports fixed adjustment for prognostic covariates using parametric regression…

未测混杂下获得统计支持的错误因果解释如何渐近出现AI 解读

Unmeasured confounding is widely recognized as a limitation of observational causal inference, but its implications for data-driven causal discovery are often understated. We provide an asymptotic characterization of this limitation. When the true causal variable is unobserved but correlated proxy variables are available, increasing sample size while searching for increasingly stable, data-driven causal structures will make associations involving observable proxies become…

多个中介变量非随机缺失下的中介分析AI 解读

Causal mediation analysis serves as a key tool for uncovering the mediating mechanisms linking treatments to outcomes. Existing methods for mediation analysis with multiple mediators typically assume complete observations or missing-at-random and may yield biased estimation when mediator values are missing not at random (MNAR). This paper studies the identification and estimation of causal mediation effects with multiple mediators subject to MNAR missingness. We consider a…

工具变量估计的新方法：TEAM-IVAI 解读

Instrumental-variable (IV) analyses can be undermined when some instruments violate the exclusion restriction through direct effects on the outcome. Existing robust IV methods, including sisVIVE and CIIV, rely on majority- or plurality-validity conditions. We propose TEAM-IV, which targets joint validity by identifying sets of instruments that appear valid together and aggregating them, allowing reliable estimation even when only a small number of candidate instruments are…

不规则历史下纵向因果推断的双重稳健函数型表示学习AI 解读

Longitudinal causal studies often record histories as irregular functional fragments: laboratory values, physiologic signals, sensor streams, and image-derived summaries measured at unequal and informative times. Standard doubly robust estimators usually require scalar summaries, whereas sequence learners optimize prediction losses that need not stabilize the efficient influence function. We propose Doubly Robust Functional Representation Learning (DR-FRL), a cross-fitted…

多重呼吸道检测时代如何选择检测阴性对照：因果视角AI 解读

The test-negative design (TND) is widely used to estimate vaccine effectiveness (VE) for respiratory pathogens by comparing vaccination odds among test-positive cases versus test-negative controls. A central yet underexplored design element is which test-negative illnesses constitute valid controls. With rapid multiplex PCR panels, investigators can now identify specific non-focal pathogens among test-negative patients, allowing for better characterization of ``test-negative…

个体化治疗规则的贝叶斯中介分析AI 解读

The value of an individualized treatment rule (ITR), defined as the expected outcome under treatment assignment according to the rule, is useful for assessing average clinical benefit but does not explain how the benefit of a rule is generated. We propose a causal mediation framework for decomposing the value contrast between a prespecified candidate ITR and a clinically meaningful reference rule into direct and indirect components. Using rule-specific nested potential…

基于半参数累积概率模型的双重稳健分位数处理效应估计AI 解读

The causal inference literature has traditionally focused on estimating the mean of the potential outcome, whereas evaluating how a treatment affects the entire outcome distribution can provide additional information in biomedical research. Quantile treatment effect (QTE) captures such distributional differences, particularly when outcomes are skewed. However, existing approaches for estimating QTE make distributional assumptions about the outcome and are thus sensitive to…

拓扑因果数据分析的数学框架AI 解读

Many modern outcomes, including images, point clouds, networks, and spatial fields, are structured objects for which \(Y^1-Y^0\) may be undefined or scientifically inadequate. We introduce \emph{Topological Causal Data Analysis} (TCDA), a framework separating the observation space, causal-model class, topological representation, and causal query. Topology does not define interventions; it supplies stable, shape-sensitive summaries after causal assumptions have been…

多状态模型的多层网络元回归：联合综合个体与汇总证据并进行人群调整AI 解读

In network meta-analysis (NMA) of oncology time-to-event outcomes, there is growing recognition that progression-free survival (PFS) and overall survival (OS) are better synthesized jointly than in separate analyses. The multistate NMA of Jansen et al. addresses this with a tri-state (stable, progressed, dead) Markov model fitted to aggregate survival curves, but it cannot adjust for imbalance in effect-modifying covariates across trials, so its relative effects may be…

非线性面板数据模型的低秩估计AI 解读

This paper investigates nonlinear panel models with interactive fixed effects and introduces a general framework for parameter estimation under potentially nonconvex objective functions. We propose a computationally feasible two-step estimation procedure. In the first step, nuclear-norm regularization (NNR) is used to obtain preliminary estimators of the coefficients of interest, factors, and factor loadings. The second step involves an iterative procedure for post-NNR…

用因果贝叶斯网络与赖欣巴赫原则重新审视格兰杰因果AI 解读

Granger causality (GC) is widely used to infer directed relationships in time-series data. However, its predictive criterion does not by itself distinguish direct causal effects from dependencies induced by common causes, indirect paths, collider conditioning, or model misspecification. We revisit this limitation by interpreting bivariate and multivariate GC through causal Bayesian networks and Reichenbachs common cause principles. Under explicit graphical assumptions,…

使用收缩估计量的自适应实验设计AI 解读

In multi-armed trials, adaptive designs are a popular way to increase estimation efficiency or identify optimal treatments. Several recent papers have proposed adaptive variants of the classical Neyman allocation to assign treatments in sequential trials, with the goal of minimizing the error of a Horvitz-Thompson-style estimator. However, this approach may be inefficient, because it fails to borrow information across the treatment arms. In this paper, we consider adaptivity…

稀疏市场—产品冲击下的离散选择需求模型估计AI 解读

When credible instruments are scarce or estimates hinge on instrument choice, an alternative to the leading Berry--Levinsohn--Pakes (BLP) approach to demand estimation with aggregate data can be useful. We propose a Bayesian random-coefficients discrete-choice demand estimator that jointly recovers preference parameters and market--product demand shocks under a sparsity restriction, without requiring instrumental variables. Shrinkage priors select a sparse set of active…

存在不依从时阶梯楔形设计的随机化推断：姑息治疗试验应用AI 解读

While palliative care is increasingly commonly delivered to hospitalized patients with serious illnesses, few studies have estimated its causal effects. Courtright et al. (2016) adopted a stepped-wedge cluster-randomized design to assess the effect of palliative care on a patient-centered outcome. The randomized intervention was a nudge to administer palliative care but did not guarantee receipt of palliative care, resulting in noncompliance. A subsequent analysis using…

干扰下不依赖暴露映射的通用因果推断框架AI 解读

We develop a general framework for design-based causal inference under interference in cluster experiments conducted via two-stage randomization on a network of interconnected units, without relying on exposure mapping assumptions, exclusion of cross-cluster interference, or Bernoulli treatment assignments. Within this framework, we establish a complete characterization of linear weighted estimators (LW) as defined by Godambe (1955) that achieve identification of various…

时间序列中的动态局部平均处理效应AI 解读

This paper discusses identification, estimation, and inference on dynamic local average treatment effects (LATEs) in instrumental variables (IVs) settings. First, we show that compliers--observations whose treatment status is affected by the instrument--can be identified individually in time series data using smoothness assumptions and local comparisons of treatment assignments. Second, we show that this result enables not only better interpretability of IV estimates but…