每日简报

二元终点单臂二期试验中贝叶斯因子功效与样本量的免模拟计算AI 解读

Bayes factors provide a coherent Bayesian measure of evidence for competing hypotheses and have recently been used as the basis for single-arm phase II trial designs with binary endpoints. In contrast to classical power analyses based on test statistics and p-values, Bayes-factor based sample size calculations target high probabilities of obtaining compelling evidence either for a relevant treatment effect or for the null hypothesis, given pre-specified Bayes-factor…

利用鞅后验推断反事实分布AI 解读

Causal inference is often focused on average effects, which can hide important aspects of the effect distributions. Here we consider the entire posterior effects distribution by estimating full counterfactual outcome distributions. We propose a methodology for inference on counterfactual distributions which builds upon the martingale posterior framework of Fong et al. (2023). This provides a highly flexible approach to estimating densities, distribution functions, and…

条件矩限制的局部稳健核设定检验AI 解读

We develop kernel-based specification tests for semiparametric conditional moment models with high-dimensional nuisance parameters, extending existing conditional moment tests---which typically require asymptotically linear nuisance estimators---to accommodate modern machine-learning methods. The proposed locally robust kernel tests combine Neyman-orthogonal moments, cross-fitting, and reproducing kernel Hilbert space methods, yielding inference that is first-order…

随机缺失下线性混合效应模型的估计与预测方差AI 解读

In linear mixed effects models (LMM), inference on fixed effects typically relies on either the generalized least squares (GLS) variance estimator obtained by assuming that the variance parameters are known, or on the Kenward-Roger method with a small-sample bias adjustment. A simulation study shows that both approaches can underestimate the variance of the treatment effect and inflate the type I error rate in large clinical trials under missing at random (MAR) mechanisms,…

Causal-TS：高维与非平稳时间序列因果发现的 Python 库AI 解读

We describe Causal-TS, an open-source Python library for causal discovery in high-dimensional and nonstationary multivariate time series. Causal-TS provides four specialized algorithms-CDNOTS, CDNOTS+, CEDAR, and GRACE-along with wrappers for GES, Granger, LASSO-VAR, and LGES, all sharing a unified conditional independence (CI) test layer with GPU acceleration via PyTorch. A regime discovery pipeline detects structural breaks via pluggable changepoint detectors and runs…

因果中介分析中的正值性假设检查AI 解读

Causal mediation analyses are increasingly used in psychological sciences. Among the required assumptions, positivity is unfortunately seldom mentioned, likely due to the lack of tools for checking it. Mediational positivity is more complex than positivity in standard, non-mediated exposure effect analysis, because it requires positivity for both the exposure and the mediator, and because the specific form of the positivity assumption depends on the mediation estimand of…

合成控制中的谱截断AI 解读

Synthetic control (SC) matches a treated unit's pre-treatment trajectory to a weighted combination of donor units. We study Spectral SC, which instead matches the treated unit in coordinates defined by the leading temporal singular vectors of the donor panel, and a hybrid estimator that places separately tunable weight on retained and discarded directions, nesting raw-path SC and truncated Spectral SC as endpoints. We prove that the family reduces exactly to raw-path SC at…

涌现的传播复杂性：区分机制复杂性与相关异质性AI 解读

Simple and complex contagions differ mechanistically; multiple exposures act synergistically in the latter but independently in the former. Yet correlated mixtures of simple contagions may appear complex when inferring global contagion rules, a phenomenon we call "emergent complexity." We present a measure of contagion complexity and an inferential framework for estimating mixtures of nonparametric contagion rules from time-series data. Our work reframes past studies on…

多状态模型的多层网络元回归：联合综合个体与汇总证据并进行人群调整AI 解读

In network meta-analysis (NMA) of oncology time-to-event outcomes, there is growing recognition that progression-free survival (PFS) and overall survival (OS) are better synthesized jointly than in separate analyses. The multistate NMA of Jansen et al. addresses this with a tri-state (stable, progressed, dead) Markov model fitted to aggregate survival curves, but it cannot adjust for imbalance in effect-modifying covariates across trials, so its relative effects may be…

去偏机器学习：识别、估计与形状约束AI 解读

We develop a general framework of identification and estimation for automatic debiased machine learning (DML) where the parameter of interest $θ_0$ is identified by a moment condition involving a nuisance $γ_0$ that may be high dimensional. We establish conditions under which the Riesz representer $α_0$, which is at the core of DML, is identified, and show that the identification occurs precisely when $α_0$ uniquely optimizes a quadratic functional. This characterization…

加权低秩矩阵近似：加速与应用AI 解读

Weighted low-rank matrix approximation (WLRMA) generalizes classical low-rank approximation and matrix completion by allowing arbitrary elementwise weights. Such formulations arise naturally in a broad class of statistical models, including generalized linear low-rank models, where WLRMA serves as the computational primitive for parameter estimation. Despite its broad applicability, efficient optimization methods for general WLRMA remain relatively underdeveloped. In this…

随机时间序列回归模型中结构断点的非参数检测AI 解读

We propose a novel nonparametric test to detect structural breaks in the conditional mean and/or variance of a time series. Our method does not assume any specific parametric form for the dependence structure of the regressor, the time series model, or the distribution of the noise. This flexibility allows our algorithm to be applicable to a wide range of framework. We further apply the proposed test to accurately localize the changepoints and establish theoretical…

MOCA：采用单向交叉注意力与反馈切断的模块化因果推断框架AI 解读

Causal effect estimation from observational data requires careful adjustment for confounding. Classical estimators such as inverse probability weighting and augmented inverse probability weighting can perform well under favorable model specification but may become unstable in complex settings. Machine-learning and representation-learning methods provide greater flexibility, but joint optimization may allow outcome information to alter treatment representations and compromise…

学会到哪里寻找数据：用于政策选择与数据收集的 Delaunay 匹配AI 解读

This paper studies data-driven policy choices from a geometric perspective. A sample from a donor population fully exposed to an innovation informs a policymaker (PM) on whether to innovate groups in a target population where the innovation was not introduced. Any wrong decision must be compensated from a finite budget and the PM seeks an estimator of the innovation's effect that guarantees an affordable compensation cost. I focus on matching estimators with positive weights…

潜在分组可能无法分离时面板模型的稳健推断AI 解读

We develop robust inference methods for general linear hypotheses in linear panel data models with latent group structure in the coefficients. We employ a selective conditional inference approach based on the conditional distribution of coefficient estimates given the group structure estimated from the data. The resulting inference procedures remain valid even when group separation fails (i.e., when the distributional properties of the group-specific coefficients are not…

误设下溢出效应的分解：伪真估计目标与局部—全局扩展AI 解读

To measure spillovers, researchers often summarize who else was treated with a simple measure, such as the share of treated neighbors. We study what the researcher estimates when that summary is misspecified. We show that the researcher estimates the best approximation to the true policy effect among all functionals of the chosen summary, and that the usual direct and spillover estimates are exactly the components of this approximation. Under a monotonicity restriction, the…

剩余生存时间分位数的贝叶斯非参数因果推断：阿尔茨海默病应用AI 解读

In Alzheimer's disease research, a clinically important question is how much longer individuals would remain dementia-free beyond a given time under different baseline amyloid statuses. We address this question using observational data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) treating baseline amyloid status as the exposure. Estimation is challenging because amyloid status is confounded, time to dementia onset is heterogeneous and heavily right censored,…

基于微观数据的一致半非参数需求估计AI 解读

This paper develops a profiled sieve minimum-distance estimator for a semi-nonparametric differentiated-products demand model with micro-level choice data. Building on Berry and Haile (2024), the estimator uses within-market variation in consumer covariates to recover a flexible consumer-heterogeneity function and market-specific composite intercepts. Excluded price instruments then separate these intercepts into a flexible price-side function and structural demand shocks.…