每日简报

在电子健康记录表型算法中使用二元银标签AI 解读

Gold-standard phenotype labels are often unavailable at scale in electronic health record (EHR) studies because they require manual chart review. Weakly supervised phenotyping methods instead use silver-standard labels, such as diagnosis-code counts, natural language processing (NLP) mentions, medication indicators, or laboratory thresholds. PheNorm is widely used for this purpose, but its original formulation was designed for count-valued silver labels and relies on log…

基于方差的治疗效应异质性检验AI 解读

This paper proposes a robust nonparametric hypothesis test for the existence of heterogeneous treatment effects. We focus on the variance of the Conditional Average Treatment Effect (CATE) as a natural omnibus parameter, where a non-zero variance implies the presence of relevant heterogeneity. Standard inference for this parameter faces a fundamental theoretical challenge. On one hand, evaluating variance components on the same sample leads to null degeneracy, where the…

非平稳时间序列局部化部分和的函数型中心极限定理AI 解读

A localized functional central limit theorem is established for kernel-weighted partial sum processes of piecewise locally stationary time series under geometric decay of the physical dependence measure. The localized process is shown to converge weakly to a centered Gaussian random distribution in $D'(0,1)$, and the limit extends naturally to an isonormal Gaussian process on $L^2([0,1])$. Weak convergence is further derived for processes indexed by totally bounded subsets…

网络元回归模型假设影响的模拟评估AI 解读

Network meta-regression (NMR) extends network meta-analysis (NMA) by synthesizing evidence on multiple treatments while adjusting for potential effect modifiers. By accounting for effect modification, NMR can reduce between-study heterogeneity and improve the validity of relative treatment effects, providing insight regarding characteristics impacting treatment performance. However, choosing between available NMR models is complex, as each model addresses a similar, but…

时变混杂下平均处理效应估计的缺失数据方法比较AI 解读

Missing data and confounding are common in real-world statistical applications, yet few studies have examined how imputation methods perform under time-varying confounding in binary variables, or how missingness mechanism, missing rate, missingness location and sample size jointly affect performance and the underlying identifiability conditions. We generated synthetic data and conducted a simulation study comparing missing data methods across scenarios varying these factors.…

ATLAS：异质环境中不变且可迁移潜在因子的识别AI 解读

This paper considers a multi-environment factor model in which high-dimensional covariates are collected from heterogeneous environments, with auxiliary labels available in a subset of these environments. The joint distribution of the covariates may vary across environments, whereas the latent structure is decomposed into invariant factors with shared loadings and heterogeneous factors with environment-specific loadings. Such a model is motivated by transfer learning and…

向量检索作为最近邻匹配：因果推断中的 RAG 政策学习AI 解读

We propose one-step and two-step methods for policy learning with retrieval-augmented generation (RAG). We formulate RAG-based action selection under the potential outcome framework. In the two-step method, vector search retrieves action-specific neighboring evidence in an embedding space, the generator estimates conditional expected outcomes or their contrasts, and a plug-in rule selects an action. This formulation connects action-specific vector search with…

不规则时间序列的因果发现AI 解读

Causal discovery methods have shown strong performance in temporal systems, but they typically rely on regular and discrete lag structures, limiting their applicability to regularly sampled data. However, many real-world tasks require dealing with irregularly sampled streams of events, such as sensor streams, healthcare data, and financial transactions. In this work, we propose an extension of PCMCI+, a state-of-the-art method for causal discovery on regular multivariate…

SPYCE：结果依赖删失下早期亨廷顿病终点的双重稳健估计AI 解读

Clinical trials for neurodegenerative diseases must identify sensitive endpoints -- outcomes that change rapidly enough to detect treatment effects. In Huntington disease, this requires measuring how outcomes change as participants approach Stage 1. Yet many participants exit studies before reaching this stage, making their time to Stage 1 right-censored. Estimating how outcomes change requires models for both time to Stage 1 and time to study exit. When participants with…

两样本孟德尔随机化的自适应惩罚与自助平滑推断AI 解读

Two-sample Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate causal effects from observational data using summary association statistics. However, horizontal pleiotropy can invalidate standard MR estimators and lead to biased causal inference. Pleiotropy-robust methods have been proposed to address this issue, including regularization-based approaches such as MR-Lasso. However, MR-Lasso may fail to identify invalid instruments…

路径签名学习有多快？路径回归的统计理论与应用AI 解读

Many prediction and decision-making problems in operations research involve path-valued covariates -- data that evolve over time -- for which path signatures have become a canonical feature representation. Their use is justified by a universal approximation theorem, but this is an existence result: it guarantees that a finite-level signature can approximate any continuous path functional, without quantifying how fast the approximation error decreases as the truncation level…

机器学习工具变量下的识别与推断AI 解读

Instrumental-variables estimation increasingly pools many or high-dimensional instruments into a single machine-learned first stage, with rich controls partialled out. The resulting estimand, the partialled-out IV coefficient built from any signal of the instruments, is a signal-weighted average of the heterogeneous effects, which gives an opaque first stage a precise structural meaning. The average is convex whenever a covariance-monotonicity condition holds, and we provide…

最优连续处理效应的识别与估计AI 解读

Estimating continuous treatment effects is hard because average-derivative estimators rely on an ill-posed conditional-density score. Recent work makes a bounded outcome weight the primitive, characterizing a class of weighted average derivative effects without density estimation. In this paper, we develop the identification and estimation theory for the optimally efficient estimands of this class under homoskedasticity and heteroskedasticity. On identification, we show that…

异质处理效应下工具变量方法的实用指南AI 解读

Instrumental variables (IV) methods are central to applied microeconomics. While classical approaches assume linear models with constant effects, recent literature has shifted toward the local average treatment effect (LATE) framework to accommodate heterogeneous treatment effects. This paper provides a practical guide to aligning empirical practice with recent theory. We first examine how different specifications with covariates lead to distinct weighted averages of…

高维高斯图模型的 spike-and-slab 贝叶斯计算AI 解读

Gaussian graphical models are widely used to infer dependence structures. Bayesian methods are appealing to quantify uncertainty associated with structural learning, i.e., the plausibility of conditional independence statements given the data, and parameter estimates. However, computational demands have limited their application when the number of variables is large, which prompted the use of pseudo-Bayesian approaches. We propose fully Bayesian algorithms that provably…

龟壳聚类：面向判别式聚类的混合方法及其在流式细胞术等数据中的应用AI 解读

Generative approaches to clustering provide information on geometric properties of clusters, whereas discriminative approaches provide boundaries between clusters. Ideas from both approaches are incorporated to present a fully unsupervised, probabilistic, and discriminative clustering method via a regularized mutual information objective function, wherein a mixture of mixtures of Gaussian and uniform distributions is used for formulation of the conditional model. Overfitting…

分数阶单整的半参数估计：局部 Whittle 方法评估AI 解读

Fractionally integrated time series, exhibiting long memory with slowly decaying autocorrelations, are frequently encountered in economics, finance, and related fields. Since the seminal work of Robinson (1995), a variety of semiparametric local Whittle estimators have been proposed for estimating the memory parameter $d$, each with a distinct range of validity and different robustness properties, leaving applied researchers to decide which to use and under what conditions.…

用于离散选择估计的表格基础模型AI 解读

Tabular foundation models (TFMs) generate predictions on structured data via in-context learning, without task-specific estimation. We ask whether TFMs can be effectively applied to discrete choice, a central demand estimation framework in marketing and operations, and find that directly applying TFMs yields limited performance. The gap is structural: TFMs assume row-independent observations, whereas discrete choice is inherently set-valued and subject to persistent consumer…

未知干扰存在时的双重差分AI 解读

The stable unit treatment value (SUTVA) is a crucial assumption in the Difference-in-Differences (DiD) research design. It rules out hidden versions of treatment and any sort of interference and spillover effects across units. Even if this is a strong assumption, it has not received much attention from DiD practitioners and, in many cases, it is not even explicitly stated as an assumption, especially the no-interference assumption. In this technical note, we investigate what…

含噪测量下高维 Ornstein–Uhlenbeck 过程的快速数据反演AI 解读

In this work, we develop a scalable approach for a flexible latent factor model for high-dimensional dynamical systems. Each latent factor process has its own correlation and variance parameters, and the orthogonal factor loading matrix can be either fixed or estimated. We utilize an orthogonal factor loading matrix that avoids computing the inversion of the posterior covariance matrix at each time of the Kalman filter, and derive closed-form expressions in an…