Which Regularized Propensity-Score and Doubly Robust Methods Are Best Calibrated When Exposures or Outcomes Are Rare? A Plasmode Study of Proxy-Based Confounding Adjustment
暴露或结局罕见时哪种正则化倾向得分与双稳健方法校准最佳?基于代理混杂调整的plasmode研究
Purpose. Confounding adjustment in health-care database studies screens large proxy libraries where events per variable are low, straining standard propensity score (PS) methods, and many regularized variable-selection strategies exist (outcome-adaptive LASSO [OAL], group LASSO/GLiDeR, highly adaptive LASSO [HAL]). Yet few comparisons have varied exposure prevalence within such a selection menu, and none pairs it with doubly robust estimation, compute accounting, and a…