Experimental Design When N Equals One
样本个体数为一时的实验设计
N-of-1 trials, or time-series experiments, are widely used in clinical research and online platforms. Yet the theoretically optimal design for estimating many treatment effects remains unclear. We propose a simple Markovian framework for experimental design in which the treatment assignment process is governed by possibly time-varying transition matrices. This formulation encompasses many existing N-of-1 designs and provides a principled way to control temporal dependence in…