每日简报

用再生核控制任意结构假设空间中的错误发现AI 解读

Large-scale hypothesis testing is central to modern science, where controlling the False Discovery Rate (FDR) has become the standard approach to managing false positives across many simultaneous tests. Hypotheses rarely exist in isolation; they often exhibit structure through proximity, connectivity, or hierarchy. This structure represents both a challenge and an opportunity: while classical methods treat these dependencies as obstacles requiring conservative correction,…

层级终点胜出统计量的样本量与功效计算：FORSS 框架AI 解读

Win statistics have gained increasing popularity as primary analysis methods for clinical trials with hierarchical endpoints (HEs) as primary endpoints. However, existing sample size and power calculation approaches in trial design still face several limitations and challenges: simulation-based approaches are computationally intensive, while existing formula-based methods often rely on simplifying assumptions such as independence among HEs, or require specification of…

平稳化变换真的改善时间序列预测吗？受控实验评估AI 解读

Stationarity transformations, such as differencing, are a common preprocessing step in forecasting, motivated by the idea that modifying a series to achieve stationarity improves accuracy. Whether this is true, and for which processes, has rarely been evaluated in controlled experiments. We study the decision to transform as the object of inquiry. We cross eighteen synthetic data-generating processes, most of them stochastic-trend processes spanning exact and near unit…

观察研究因果推断的样本量与功效计算AI 解读

This paper investigates the theoretical foundation and develops analytical formulas for sample size and power calculations for causal inference with observational data. By analyzing the variance of an inverse probability weighting estimator of the average treatment effect, we decompose the power calculation into three components: propensity score distribution, potential outcome distribution, and their correlation. We show that to determine the minimal sample size of an…

高维部分线性模型与趋势滤波AI 解读

Understanding the links between diet, metabolic changes, and health outcomes is a key focus in nutritional science and broader biological research. Analyzing relationships, such as those between ultra-processed food (UPF) intake and metabolites, offers insights into potential biomarkers for diet-related diseases and public health applications. However, these analyses are challenging due to high-dimensional data structures and complex, often nonlinear associations between…

SMART 微调：因子增强神经网络 LassoAI 解读

Fine-tuning is a widely used strategy for adapting pre-trained models to new tasks, yet its methodology and theoretical properties in high-dimensional nonparametric settings with variable selection have not yet been developed. We propose a source-model-augmented residual tuning (SMART) framework, which incorporates the pre-trained source model as an augmented feature into the target learner and estimates only the residual target-specific component. The approach is widely…

通过校准大规模观察结局迁移处理效应AI 解读

A high-quality experimental dataset is often much smaller than a corresponding observational dataset. When this holds with possibly biased measurements of the outcome of interest in the latter, we propose an estimation and inference procedure for a transported treatment effect. Our point estimator can be computed as follows. First, we estimate the conditional average treatment effect (CATE) by calibrating a treatment-control contrast estimated using the observational…

合成控制的松弛方法AI 解读

The synthetic control method (SCM) is widely used for constructing the counterfactual of a treated unit based on data from control units in a donor pool. Allowing the donor pool contains more control units than time periods, we propose a novel machine learning algorithm, named SCM-relaxation, for counterfactual prediction. Our relaxation approach minimizes an information-theoretic measure of the weights subject to a set of relaxed linear inequality constraints in addition to…

SC3D：时序与即时因果图的动态可微发现AI 解读

Discovering causal structures from multivariate time series is a key problem because interactions span across multiple lags and possibly involve instantaneous dependencies. Additionally, the search space of the dynamic graphs is combinatorial in nature. In this study, we propose Stable Causal Dynamic Differentiable Discovery (SC3D), a two-stage differentiable framework that jointly learns lag-specific adjacency matrices and, if present, an instantaneous directed acyclic…