Asymptotic Properties of Multi-Treatment Covariate Adaptive Randomization Procedures for Balancing Observed and Unobserved Covariates
平衡已观测与未观测协变量的多处理协变量自适应随机化:渐近性质
Applications of CAR for balancing continuous covariates remain comparatively rare, especially in multi-treatment clinical trials, and the theoretical properties of multi-treatment CAR have remained largely elusive for decades. In this paper, we consider a general framework of CAR procedures for multi-treatment clinal trials which can balance general covariate features, such as quadratic and interaction terms which can be discrete, continuous, and mixing. We show that under…