每日简报

条件函数图模型中识别差异网络的近邻选择方法AI 解读

Estimating how different brain regions communicate with each other using EEG data is valuable both for medical research and clinical diagnosis. This involves quantifying the statistical dependencies among the activities of different brain areas, captured by the time-varying electric field recorded by scalp sensors. These dependencies can vary within and across individuals also in relationship with external factors such as age, mental state, or disease severity. Motivated by…

使用稳健 MAP 先验评估区域处理效应AI 解读

Bayesian dynamic borrowing has become an increasingly important tool for evaluating the consistency of regional treatment effects which is a key requirement for local regulatory approval of a new drug. It helps increase the precision of regional treatment effect estimate when regional and global data are similar, while guarding against potential bias when they differ. In practice, the two-component mixture prior, of which one mixture component utilizes the power prior to…

Hermite 过程的修正加权幂变差及其在积分波动率估计中的应用AI 解读

We study the asymptotic behaviour of modified weighted power variations of the Hermite process of arbitrary order. By selecting suitable "good" increments and exploiting their decomposition into dominant independent components, we establish a central limit theorem for weighted $p$-variations using tools from Stein-Malliavin calculus. Our results extend previous works on modified quadratic and wavelet-based variations to general powers and to weighted settings, with explicit…

基于强化学习的高效动态离散选择模型条件选择模拟估计AI 解读

Dynamic discrete choice (DDC) models have found widespread application in marketing. However, estimating these becomes challenging in "big data" settings with high-dimensional state-action spaces. To address this challenge, this paper develops a Reinforcement Learning (RL)-based two-step ("computationally light") Conditional Choice Simulation (CCS) estimation approach that combines the scalability of machine learning with the transparency, explainability, and…

利用协变量注释信息提高 Knockoff 变量选择的功效AI 解读

Genome-wide association studies (GWAS) often find association signals between many genetic variants and traits of interest in a genomic region. Functional annotations of these variants provide valuable prior information that helps prioritize biologically relevant variants and enhances the power to detect causal variants. However, due to substantial correlations among these variants, a critical question is how to rigorously control the false discovery rate while effectively…

带连续标记的删失数据因果推断AI 解读

This paper presents a framework for causal inference in the presence of censored data,where the failure time is marked by a continuous variable referred to as a mark.The mark is observed after treatment and is not meaningful when the failure time is censored. In addition, due to the continuous nature of the marks, observations at each given mark are sparse. These facts make the identification and estimation of causality a challenging task. To address these issues, we define…

利用代理变量与工具变量处理 Perturb-seq 中的未观测混杂AI 解读

Emerging single-cell technologies that combine CRISPR-based genetic perturbations with single-cell RNA sequencing, such as Perturb-seq, offer unprecedented opportunities to uncover cause-and-effect relationships among genes. Nonetheless, Perturb-seq experiments are subject to unobserved factors that, if not properly handled, can severely bias the inferred causal relationships between genes. These latent factors may arise not only from intrinsic molecular features of the…

环境自适应协变量选择：分布外预测中何时利用伪相关AI 解读

A common approach to out-of-distribution prediction restricts models to causal or invariant covariates to avoid spurious associations that may change across environments. Despite its theoretical appeal, this strategy can underperform empirical risk minimization when only a subset of the causal parents of the outcome is observed. In such settings, non-causal covariates can serve as proxies for unobserved causal parents and improve prediction when the proxy relationship is…

基于组 Lasso 选择的高维中介分析AI 解读

Mediation analysis aims to identify and estimate the effect of an exposure on an outcome that is mediated through one or more intermediate variables. In the presence of multiple intermediate variables, two pertinent methodological questions arise: estimating mediated effects when mediators are correlated, and performing high-dimensional mediation analyses when the number of mediators exceeds the sample size. This paper presents a two-step procedure for high-dimensional…

We consider statistical inference in high-dimensional regression problems under affine constraints on the parameter space. The theoretical study of this is motivated by the study of genetic determinants of diseases, such as diabetes, using external information from mediating protein expression levels. Specifically, we develop rigorous methods for estimating genetic effects on diabetes-related continuous outcomes when these associations are constrained based on external…

一般线性泛函估计的尖锐结构无关下界AI 解读

We establish a general statistical optimality theory for estimation problems where the target parameter is a linear functional of an unknown nuisance component that must be estimated from data. This formulation covers many causal and predictive parameters and has applications to numerous disciplines. We adopt the structure-agnostic framework introduced by \citet{balakrishnan2023fundamental}, which poses no structural properties on the nuisance functions other than access to…