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Robust Post-Matching Inference

匹配后的稳健统计推断

Nearest-neighbor matching is a popular nonparametric tool to create balance between treatment and control groups in observational studies. As a preprocessing step before regression, matching reduces the dependence on parametric modeling assumptions. In current empirical practice, however, the matching step is often ignored in the calculation of standard errors and confidence intervals. In this article, we show that ignoring the matching step results in asymptotically valid…

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Nonlinear Spectral Analysis: A Local Gaussian Approach

非线性谱分析:局部高斯方法

The spectral distribution f(ω) of a stationary time series {Yt}t∈Z can be used to investigate whether or not periodic structures are present in {Yt}t∈Z, but f(ω) has some limitations due to its dependence on the autocovariances γ(h). For example, f(ω) can not distinguish white iid noise from GARCH-type models (whose terms are dependent, but uncorrelated), which implies that f(ω) can be an inadequate tool when {Yt}t∈Z contains asymmetries and nonlinear dependencies.…

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Heteroscedasticity-Adjusted Ranking and Thresholding for Large-Scale Multiple Testing

大规模多重检验中的异方差调整排序与阈值方法

Standardization has been a widely adopted practice in multiple testing, for it takes into account the variability in sampling and makes the test statistics comparable across different study units. However, despite conventional wisdom to the contrary, we show that there can be a significant loss in information from basing hypothesis tests on standardized statistics rather than the full data. We develop a new class of heteroscedasticity-adjusted ranking and thresholding (HART)…

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Asymptotic Theory of Eigenvectors for Random Matrices With Diverging Spikes

具有发散尖峰的随机矩阵特征向量渐近理论

Characterizing the asymptotic distributions of eigenvectors for large random matrices poses important challenges yet can provide useful insights into a range of statistical applications. To this end, in this paper we introduce a general framework of asymptotic theory of eigenvectors (ATE) for large spiked random matrices with diverging spikes and heterogeneous variances, and establish the asymptotic properties of the spiked eigenvectors and eigenvalues for the scenario of…

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Causal Bounds for Outcome-Dependent Sampling in Observational Studies

观察性研究中结局依赖抽样的因果效应界

Outcome-dependent sampling designs are common in many different scientific fields including epidemiology, ecology, and economics. As with all observational studies, such designs often suffer from unmeasured confounding, which generally precludes the nonparametric identification of causal effects. Nonparametric bounds can provide a way to narrow the range of possible values for a nonidentifiable causal effect without making additional untestable assumptions. The nonparametric…

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Center-Outward R-Estimation for Semiparametric VARMA Models

半参数 VARMA 模型的中心向外秩估计

We propose a new class of R-estimators for semiparametric VARMA models in which the innovation density plays the role of the nuisance parameter. Our estimators are based on the novel concepts of multivariate center-outward ranks and signs. We show that these concepts, combined with Le Cam’s asymptotic theory of statistical experiments, yield a class of semiparametric estimation procedures, which are efficient (at a given reference density), root-n consistent, and…

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Highly Scalable Bayesian Geostatistical Modeling via Meshed Gaussian Processes on Partitioned Domains

基于分区域网格化高斯过程的高可扩展贝叶斯地统计建模

We introduce a class of scalable Bayesian hierarchical models for the analysis of massive geostatistical datasets. The underlying idea combines ideas on high-dimensional geostatistics by partitioning the spatial domain and modeling the regions in the partition using a sparsity-inducing directed acyclic graph (DAG). We extend the model over the DAG to a well-defined spatial process, which we call the Meshed Gaussian Process (MGP). A major contribution is the development of a…

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Learning Latent Factors From Diversified Projections and Its Applications to Over-Estimated and Weak Factors

从分散化投影学习潜在因子:因子数高估与弱因子的应用

Estimations and applications of factor models often rely on the crucial condition that the number of latent factors is consistently estimated, which in turn also requires that factors be relatively strong, data are stationary and weakly serially dependent, and the sample size be fairly large, although in practical applications, one or several of these conditions may fail. In these cases, it is difficult to analyze the eigenvectors of the data matrix. To address this issue,…

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A Minimax Optimal Ridge-Type Set Test for Global Hypothesis With Applications in Whole Genome Sequencing Association Studies

全局假设的极小极大最优岭型集合检验及全基因组测序应用

Testing a global hypothesis for a set of variables is a fundamental problem in statistics with a wide range of applications. A few well-known classical tests include the Hotelling’s T 2 test, the F-test, and the empirical Bayes based score test. These classical tests, however, are not robust to the signal strength and could have a substantial loss of power when signals are weak or moderate, a situation we commonly encounter in contemporary applications. In this article, we…

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Heteroscedasticity-Robust Inference in Linear Regression Models With Many Covariates

含大量协变量的线性回归异方差稳健推断

We consider inference in linear regression models that is robust to heteroscedasticity and the presence of many control variables. When the number of control variables increases at the same rate as the sample size the usual heteroscedasticity-robust estimators of the covariance matrix are inconsistent. Hence, tests based on these estimators are size distorted even in large samples. An alternative covariance-matrix estimator for such a setting is presented that complements…

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Warp Bridge Sampling: The Next Generation

Warp 桥采样的新一代方法

Bridge sampling is an effective Monte Carlo (MC) method for estimating the ratio of normalizing constants of two probability densities, a routine computational problem in statistics, physics, chemistry, and other fields. The MC error of the bridge sampling estimator is determined by the amount of overlap between the two densities. In the case of unimodal densities, Warp-I, II, and III transformations are effective for increasing the initial overlap, but they are less so for…

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Estimating Number of Factors by Adjusted Eigenvalues Thresholding

通过调整特征值阈值估计因子数量

Determining the number of common factors is an important and practical topic in high dimensional factor models. The existing literatures are mainly based on the eigenvalues of the covariance matrix. Due to the incomparability of the eigenvalues of the covariance matrix caused by heterogeneous scales of observed variables, it is very difficult to give an accurate relationship between these eigenvalues and the number of common factors. To overcome this limitation, we appeal to…

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Bayesian Regression Using a Prior on the Model Fit: The R2-D2 Shrinkage Prior

基于模型拟合度先验的贝叶斯回归:R2-D2 收缩先验

Prior distributions for high-dimensional linear regression require specifying a joint distribution for the unobserved regression coefficients, which is inherently difficult. We instead propose a new class of shrinkage priors for linear regression via specifying a prior first on the model fit, in particular, the coefficient of determination, and then distributing through to the coefficients in a novel way. The proposed method compares favorably to previous approaches in terms…

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Balancing Unobserved Covariates With Covariate-Adaptive Randomized Experiments

协变量自适应随机实验中的未观测协变量平衡

Balancing important covariates is often critical in clinical trials and causal inference. Stratified permuted block (STR-PB) and covariate-adaptive randomization (CAR) procedures are widely used to balance observed covariates in practice. The balance properties of these procedures with respect to the observed covariates have been well studied. However, it has been questioned whether these methods will also yield a good balance for the unobserved covariates. In this article,…

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Simultaneous Detection of Signal Regions Using Quadratic Scan Statistics With Applications to Whole Genome Association Studies

利用二次扫描统计量同时检测信号区域及全基因组关联应用

We consider in this paper detection of signal regions associated with disease outcomes in whole genome association studies. Gene- or region-based methods have become increasingly popular in whole genome association analysis as a complementary approach to traditional individual variant analysis. However, these methods test for the association between an outcome and the genetic variants in a pre-specified region, e.g., a gene. In view of massive intergenic regions in whole…

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Low-Rank Covariance Function Estimation for Multidimensional Functional Data

多维函数型数据的低秩协方差函数估计

Jiayi Wanga, Raymond K. W. Wonga* & Xiaoke Zhangb a Department of Statistics, Texas A&M University, College Station, TX; b Department of Statistics, George Washington University, Washington, DC Supplementary materials for this article are available online. Please go to www.tandfonline.com/r/JASA. CONTACT Raymond K. W. Wong raywong@tamu.edu Department of Statistics, Texas A&M University , College Station , TX 77843.AbstractMultidimensional function data arise from many fields…

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Large-Scale Datastreams Surveillance via Pattern-Oriented-Sampling

基于模式导向抽样的大规模数据流监测

Monitoring large-scale datastreams with limited resources has become increasingly important for real-time detection of abnormal activities in many applications. Despite the availability of large datasets, the challenges associated with designing an efficient change-detection when clustering or spatial pattern exists are not yet well addressed. In this article, a design-adaptive testing procedure is developed when only a limited number of streaming observations can be…

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Copula Gaussian Graphical Models for Functional Data

函数型数据的 Copula 高斯图模型

We introduce a statistical graphical model for multivariate functional data, which are common in medical applications such as EEG and fMRI. Recently published functional graphical models rely on the multivariate Gaussian process assumption, but we relax it by introducing the functional copula Gaussian graphical model (FCGGM). This model removes the marginal Gaussian assumption but retains the simplicity of the Gaussian dependence structure, which is particularly attractive…

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Nonparametric Maximum Likelihood Methods for Binary Response Models With Random Coefficients

随机系数二元响应模型的非参数极大似然方法

The venerable method of maximum likelihood has found numerous recent applications in nonparametric estimation of regression and shape constrained densities. For mixture models the nonparametric maximum likelihood estimator (NPMLE) of Kiefer and Wolfowitz plays a central role in recent developments of empirical Bayes methods. The NPMLE has also been proposed by Cosslett as an estimation method for single index linear models for binary response with random coefficients.…

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A Semiparametric Approach to Model Effect Modification

刻画效应修饰的半参数方法

One fundamental statistical question for research areas such as precision medicine and health disparity is about discovering effect modification of treatment or exposure by observed covariates. We propose a semiparametric framework for identifying such effect modification. Instead of using the traditional outcome models, we directly posit semiparametric models on contrasts, or expected differences of the outcome under different treatment choices or exposures. Through…

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Monte Carlo Approximation of Bayes Factors via Mixing With Surrogate Distributions

通过与替代分布混合进行贝叶斯因子的蒙特卡洛近似

By mixing the target posterior distribution with a surrogate distribution, of which the normalizing constant is tractable, we propose a method for estimating the marginal likelihood using the Wang–Landau algorithm. We show that a faster convergence of the proposed method can be achieved via the momentum acceleration. Two implementation strategies are detailed: (i) facilitating global jumps between the posterior and surrogate distributions via the multiple-try Metropolis…

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Inferring Phenotypic Trait Evolution on Large Trees With Many Incomplete Measurements

在大量测量不完整的大型系统发育树上推断表型性状演化

Comparative biologists are often interested in inferring covariation between multiple biological traits sampled across numerous related taxa. To properly study these relationships, we must control for the shared evolutionary history of the taxa to avoid spurious inference. An additional challenge arises as obtaining a full suite of measurements becomes increasingly difficult with increasing taxa. This generally necessitates data imputation or integration, and existing…

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Cross-Validation for Correlated Data

相关数据的交叉验证

–K-fold cross-validation (CV) with squared error loss is widely used for evaluating predictive models, especially when strong distributional assumptions cannot be taken. However, CV with squared error loss is not free from distributional assumptions, in particular in cases involving non-iid data. This article analyzes CV for correlated data. We present a criterion for suitability of standard CV in presence of correlations. When this criterion does not hold, we introduce a…

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Estimation of Low Rank High-Dimensional Multivariate Linear Models for Multi-Response Data

面向多响应数据的低秩高维多元线性模型估计

In this article, we study low rank high-dimensional multivariate linear models (LRMLM) for high-dimensional multi-response data. We propose an intuitively appealing estimation approach and develop an algorithm for implementation purposes. Asymptotic properties are established to justify the estimation procedure theoretically. Intensive simulation studies are also conducted to demonstrate performance when the sample size is finite, and a comparison is made with some popular…

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