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Kanti Mardia’s contribution to the Discussion of ‘the Discussion Meeting on Probabilistic and statistical aspects of machine learning’

Kanti Mardia 对“机器学习的概率与统计方面”讨论会论文的评论

I enjoyed reading this paper which has so many outstanding features; this is where Modern Statistics is moving—high-level computing with sound mathematical statistical. My comments are as follows. The authors use the wrapped normal on SO(3) using the exponential map and I have some reservations related to this choice since the most common distribution used on SO(3) is the Fisher matrix distribution which has many desirable properties (see, e.g. Mardia & Jupp, 2000) whereas…

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Andi Wang’s contribution to the Discussion of ‘the Discussion Meeting on Probabilistic and statistical aspects of machine learning’

Andi Wang 对“机器学习概率与统计方面讨论会”的评论

I would like to congratulate the authors for this excellent article, which includes both careful theoretical developments at the foundations of such denoising models and exciting methodological innovations and experiments. Of course, there are still many unanswered questions in relation to these denoising Markov models. One of the most tantalizing such questions is touched on by the authors in their concluding discussion, namely the nature of the implicit biases which are…

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Shakeel Gavioli-Akilagun’s contribution to the Discussion of ‘the Discussion Meeting on Probabilistic and statistical aspects of machine learning’

Shakeel Gavioli-Akilagun 对机器学习概率与统计讨论会论文的评论

We congratulate the authors for the interesting and thought provoking paper. Lemma 3.2 shows that the generalized likelihood ratio (GLR) test for stability of a linear regression can be viewed as a simple feed forward neural network. However, close inspection of the lemma reveals that the setup rules out several common change point problems. Consider the piecewise polynomial regression: For ξ ’s distributed i.i.d. N(0,1)⁠, the likelihood ratio statistic for a change at…

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Proposer of the vote of thanks and contribution to the Discussion of ‘the Discussion Meeting on Probabilistic and statistical aspects of machine learning’

关于“机器学习的概率与统计方面”讨论会的致谢提议与讨论意见

Computational statistics and machine learning (ML) are closely related, and there are many opportunities for cross-fertilization of ideas between the two fields. Both can benefit from greater interaction, and the two papers being discussed here highlight some ways that this can happen. The main focus of this paper is offline detection of a single change-point using labelled training data. Interest is in the automatic generation of new offline detection methods using neural…

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Identification and estimation of causal peer effects using double negative controls for unmeasured network confounding

利用双重负对照识别与估计存在未测网络混杂的同伴因果效应

Abstract Identification and estimation of causal peer effects are challenging in observational studies for two reasons. The first is the identification challenge due to unmeasured network confounding, for example, homophily bias and contextual confounding. The second is network dependence of observations. We establish a framework that leverages a pair of negative control outcome and exposure variables (double negative controls) to non-parametrically identify causal peer…

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Least squares estimation of a quasiconvex regression function

准凸回归函数的最小二乘估计

Abstract We develop a new approach for the estimation of a multivariate function based on the economic axioms of quasiconvexity (and monotonicity). On the computational side, we prove the existence of the quasiconvex constrained least squares estimator (LSE) and provide a characterisation of the function space to compute the LSE via a mixed-integer quadratic programme. On the theoretical side, we provide finite sample risk bounds for the LSE via a sharp oracle inequality.…

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Ensemble methods for testing a global null

检验全局原假设的集成方法

Abstract Testing a global null is a canonical problem in statistics and has a wide range of applications. In view of the fact that no uniformly most powerful test exists, prior and/or domain knowledge are commonly used to focus on a certain class of alternatives to improve the testing power. However, it is generally challenging to develop tests that are particularly powerful against a certain class of alternatives. In this paper, motivated by the success of ensemble learning…

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Non-agency interventions for causal mediation in the presence of intermediate confounding

中间混杂下因果中介分析的信息传递干预

Abstract Recent approaches to causal inference have focused on causal effects defined as contrasts between the distribution of counterfactual outcomes under hypothetical interventions on the nodes of a graphical model. In this article, we develop theory for causal effects defined with respect to a different type of intervention, one which alters the information propagated through the edges of the graph. These information transfer interventions may be more useful than node…

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Adaptive bootstrap tests for composite null hypotheses in the mediation pathway analysis

中介路径分析中复合原假设的自适应 Bootstrap 检验

Abstract Mediation analysis aims to assess if, and how, a certain exposure influences an outcome of interest through intermediate variables. This problem has recently gained a surge of attention due to the tremendous need for such analyses in scientific fields. Testing for the mediation effect (ME) is greatly challenged by the fact that the underlying null hypothesis (i.e. the absence of MEs) is composite. Most existing mediation tests are overly conservative and thus…

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Controlling the false discovery rate in transformational sparsity: Split Knockoffs

变换稀疏性中的错误发现率控制:Split Knockoffs

Abstract Controlling the False Discovery Rate (FDR) in a variable selection procedure is critical for reproducible discoveries, and it has been extensively studied in sparse linear models. However, it remains largely open in scenarios where the sparsity constraint is not directly imposed on the parameters but on a linear transformation of the parameters to be estimated. Examples of such scenarios include total variations, wavelet transforms, fused LASSO, and trend filtering.…

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Bayesian predictive decision synthesis

贝叶斯预测决策综合

Abstract Decision-guided perspectives on model uncertainty expand traditional statistical thinking about managing, comparing, and combining inferences from sets of models. Bayesian predictive decision synthesis (BPDS) advances conceptual and theoretical foundations, and defines new methodology that explicitly integrates decision-analytic outcomes into the evaluation, comparison, and potential combination of candidate models. BPDS extends recent theoretical and practical…

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Estimating Trans-Ancestry Genetic Correlation with Unbalanced Data Resources

数据资源不平衡下的跨祖源遗传相关性估计

The aim of this paper is to propose a novel method for estimating trans-ancestry genetic correlations in genome-wide association studies (GWAS) using genetically-predicted observations. These correlations describe how genetic architecture of complex traits varies among populations. Our new estimator corrects for biases arising from prediction errors in high-dimensional weak GWAS signals, while addressing the ethnic diversity inherent in GWAS data, such as linkage…

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Addressing Multiple Detection Limits with Semiparametric Cumulative Probability Models

用半参数累积概率模型处理多重检测限

Detection limits (DLs), where a variable cannot be measured outside of a certain range, are common in research. DLs may vary across study sites or over time. Most approaches to handling DLs in response variables implicitly make strong parametric assumptions on the distribution of data outside DLs. We propose a new approach to deal with multiple DLs based on a widely used ordinal regression model, the cumulative probability model (CPM). The CPM is a rank-based, semiparametric…

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Heterogeneity Analysis on Multi-State Brain Functional Connectivity and Adolescent Neurocognition

多状态脑功能连接与青少年认知的异质性分析

Brain functional connectivity or connectome, a unique measure for brain functional organization, provides a great potential to explain the neurobiological underpinning of behavioral profiles. Existing connectome-based analyses highly concentrate on brain activities under a single cognitive state, and fail to consider heterogeneity when attempting to characterize brain-to-behavior relationships. In this work, we study the complex impact of multi-state functional connectivity…

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Leveraging Weather Dynamics in Insurance Claims Triage Using Deep Learning

利用深度学习将天气动态纳入保险理赔分流

In property insurance claims triage, insurers often use static information to assess the severity of a claim and to identify the subsequent actions. We hypothesize that the pattern of weather conditions throughout the course of a loss event is predictive of the insured losses, and hence appropriate use of weather dynamics improves the operation of insurers’ claim management. To test this hypothesis, we propose a deep learning method to incorporate dynamic weather information…

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Estimating Cell-Type-Specific Gene Co-Expression Networks from Bulk Gene Expression Data with an Application to Alzheimer’s Disease

从整体基因表达数据估计细胞类型特异共表达网络

Inferring and characterizing gene co-expression networks has led to important insights on the molecular mechanisms of complex diseases. Most co-expression analyses to date have been performed on gene expression data collected from bulk tissues with different cell type compositions across samples. As a result, the co-expression estimates only offer an aggregated view of the underlying gene regulations and can be confounded by heterogeneity in cell type compositions, failing…

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Independence Weights for Causal Inference with Continuous Treatments

连续处理因果推断的独立性权重

Studying causal effects of continuous treatments is important for gaining a deeper understanding of many interventions, policies, or medications, yet researchers are often left with observational studies for doing so. In the observational setting, confounding is a barrier to the estimation of causal effects. Weighting approaches seek to control for confounding by reweighting samples so that confounders are comparable across different treatment values. Yet, for continuous…

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Survival Mixed Membership Blockmodel

生存混合成员区块模型

Whenever we send a message via a channel such as e-mail, Facebook, WhatsApp, WeChat, or LinkedIn, we care about the response rate—the probability that our message will receive a response—and the response time—how long it will take to receive a reply. Recent studies have made considerable efforts to model the sending behaviors of messages in social networks with point processes. However, statistical research on modeling response rates and response times on social networks is…

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A Hierarchical Expected Improvement Method for Bayesian Optimization

用于贝叶斯优化的层级期望改进方法

The Expected Improvement (EI) method, proposed by Jones, Schonlau, andWelch, is a widely used Bayesian optimization method, which makes use of a fitted Gaussian process model for efficient black-box optimization. However, one key drawback of EI is that it is overly greedy in exploiting the fitted Gaussian process model for optimization, which results in suboptimal solutions even with large sample sizes. To address this, we propose a new hierarchical EI (HEI) framework, which…

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Narrowest Significance Pursuit: Inference for Multiple Change-Points in Linear Models

最窄显著区间搜寻:线性模型中的多变点推断

We propose Narrowest Significance Pursuit (NSP), a general and flexible methodology for automatically detecting localised regions in data sequences which each must contain a change-point (understood as an abrupt change in the parameters of an underlying linear model), at a prescribed global significance level. NSP works with a wide range of distributional assumptions on the errors, and guarantees important stochastic bounds which directly yield exact desired coverage…

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Large-Scale Two-Sample Comparison of Support Sets

支撑集的大规模两样本比较

Two-sample multiple testing has a wide range of applications. Most of the literature considers simultaneous tests of equality of parameters. The article takes a different perspective and investigates the null hypotheses that the two support sets are equal. This formulation of the testing problem is motivated by the fact that in many applications where the two parameter vectors being compared are both sparse, one might be more concerned about the detection of differential…

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Censored Interquantile Regression Model with Time-Dependent Covariates

含时变协变量的删失分位区间回归模型

Conventionally, censored quantile regression stipulates a specific, pointwise conditional quantile of the survival time given covariates.Despite its model flexibility and straightforward interpretation, the pointwise formulation oftentimes yields rather unstable estimates across neighboring quantile levels with large variances.In view of this phenomenon, we propose a new class of quantile-based regression models with timedependent covariates for censored data.The models…

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Estimation of Linear Functionals in High-Dimensional Linear Models: From Sparsity to Nonsparsity

高维线性模型中线性泛函的估计:从稀疏到非稀疏

can be sparse or non-sparse and predictors can be strongly or weakly correlated. The proposed method is simple for implementation. Numerical and theoretical results demonstrate the competitive advantages of the proposed method for a wide range of problems.

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