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Bias correction of quadratic spectral estimators

二次谱估计量的偏误修正

Summary The three cardinal, statistically consistent families of nonparametric estimators for the power spectral density of a time series are the lag-window, multitaper and Welch estimators. However, when estimating power spectral densities from a finite sample, each can be subject to nonignorable bias. Astfalck et al. (2024) developed a method that offers significant bias reduction for finite samples for Welch’s estimator, which this article extends to the larger family of…

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Integer programming for learning directed acyclic graphs from nonidentifiable Gaussian models

非可识别高斯模型中有向无环图学习的整数规划

Summary We study the problem of learning directed acyclic graphs from continuous observational data, generated according to a linear Gaussian structural equation model. State-of-the-art structure learning methods for this setting have at least one of the following shortcomings: (i) they cannot provide optimality guarantees and can suffer from learning suboptimal models; (ii) they rely on the stringent assumption that the noise is homoscedastic, and hence the underlying model…

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Towards a turnkey approach for unbiased Monte Carlo estimation of smooth functions of expectations

期望的光滑函数之无偏蒙特卡洛估计:迈向自动化方法

Abstract Given a smooth function $ f $, we develop a general approach to turn Monte Carlo samples with expectation $ m $ into an unbiased estimate of $ f(m) $. Specifically, we develop estimators that are based on randomly truncating the Taylor series expansion of $ f $ and estimating the coefficients of the truncated series. We derive their properties and propose a strategy to set their tuning parameters (which depend on $ m $) automatically, with a view to making the whole…

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A general form of covariate adjustment in clinical trials under covariate-adaptive randomization

协变量自适应随机化临床试验中的一般协变量调整

Abstract In randomized clinical trials, adjusting for baseline covariates can improve credibility and efficiency for demonstrating and quantifying treatment effects. This article studies the augmented inverse propensity weighted estimator, which is a general form of covariate adjustment that uses linear, generalized linear and nonparametric or machine learning models for the conditional mean of the response given covariates. Under covariate-adaptive randomization, we…

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Dynamic factor analysis of high-dimensional recurrent events

高维重复事件的动态因子分析

Summary Recurrent event time data arise in many studies, including in biomedicine, public health, marketing and social media analysis. High-dimensional recurrent event data involving many event types and observations have become prevalent with advances in information technology. This article proposes a semiparametric dynamic factor model for the dimension reduction of high-dimensional recurrent event data. The proposed model imposes a low-dimensional structure on the mean…

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Improving efficiency in transporting average treatment effects

提高平均处理效应跨总体迁移的估计效率

Abstract We develop flexible, semiparametric estimators of the average treatment effect transported to a new target population, which offer potential efficiency gains. Transport may be of value when the average treatment effect may differ across populations. We consider the setting where differences in the average treatment effect are due to differences in the distribution of effect modifiers, baseline covariates that modify the treatment effect. First, we propose a…

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A spike-and-slab prior for dimension selection in generalized linear network eigenmodels

广义线性网络特征模型中用于维度选择的尖峰与厚尾先验

Summary Latent space models are often used to model network data by embedding a network’s nodes into a low-dimensional latent space; however, choosing the dimension of this space remains a challenge. To this end, we begin by formalizing a class of latent space models we call generalized linear network eigenmodels that can model various edge types (binary, ordinal, nonnegative continuous) found in scientific applications. This model class subsumes the traditional eigenmodel…

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Transfer learning for piecewise-constant mean estimation: optimality, ℓ 1 and ℓ 0 penalization

分段常数均值估计的迁移学习:最优性与ℓ₁、ℓ₀惩罚

Summary We study transfer learning for estimating piecewise-constant signals when source data, which may be relevant but disparate, are available in addition to target data. We first investigate transfer learning estimators that respectively employ $ \ell_{1} $ and $ \ell_{0} $ penalties for unisource data scenarios and then generalize these estimators to accommodate multisources. To further reduce estimation errors, especially when some sources significantly differ from the…

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Prediction sets for high-dimensional mixture of experts models

高维混合专家模型的预测集

Abstract Large datasets make it possible to build predictive models that can capture heterogenous relationships between the response variable and features. The mixture of high-dimensional linear experts model posits that observations come from a mixture of high-dimensional linear regression models, where the mixture weights are themselves feature-dependent. In this article, we show how to construct valid prediction sets for an ℓ1-penalized mixture of experts model in the…

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Spatial effect detection regression for large-scale spatio-temporal covariates

面向大规模时空协变量的空间效应检测回归

Abstract We develop a Spatial Effect Detection Regression (SEDR) model to capture the nonlinear and irregular effects of high-dimensional spatio-temporal predictors on a scalar outcome. Specifically, we assume that both the component and the coefficient functions in the SEDR are unknown smooth functions of location and time. This allows us to leverage spatially and temporally correlated information, transforming the curse of dimensionality into a blessing, as confirmed by…

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α -separability and adjustable combination of amplitude and phase model for functional data

函数型数据的 α 可分离性与幅度、相位的可调组合模型

Abstract We consider separating and joint modelling amplitude and phase variations for functional data in an identifiable manner. To rigorously address this separability issue, we introduce the notion of α-separability upon constructing a family of α-indexed metrics. We bridge α-separability with the uniqueness of Fréchet mean, leading to the proposed adjustable combination of amplitude and phase model. The parameter α allows user-defined modelling emphasis between vertical…

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Robust evaluation of longitudinal surrogate markers with censored data

删失数据下纵向替代指标的稳健评估

Abstract The development of statistical methods to evaluate surrogate markers is an active area of research. In many clinical settings, the surrogate marker is not simply a single measurement but is instead a longitudinal trajectory of measurements over time, e.g. fasting plasma glucose measured every 6 months for 3 years. In general, available methods developed for the single-surrogate setting cannot accommodate a longitudinal surrogate marker. Furthermore, many of the…

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Dynamic modelling of sparse longitudinal data and functional snippets with stochastic differential equations

利用随机微分方程动态建模稀疏纵向数据与函数片段

Abstract Sparse functional/longitudinal data have attracted widespread interest due to the prevalence of such data in social and life sciences. A prominent scenario where such data are routinely encountered are accelerated longitudinal studies, where subjects are enrolled in the study at a random time and are only tracked for a short amount of time relative to the domain of interest. The statistical analysis of such functional snippets is challenging since information for…

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Moving beyond population variable importance: concept, theory and applications of individual variable importance

超越总体变量重要性:个体变量重要性的概念、理论与应用

Abstract In a non-parametric regression setting, we introduce a novel concept of ‘individual variable importance’, which assesses the relevance of certain covariates to an outcome variable among individuals with specific characteristics. This concept holds practical importance for both risk assessment and association identification. For example, it can represent (i) the usefulness of expensive biomarkers in risk prediction for individuals at a specified baseline risk, or…

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Scalable couplings for the random walk Metropolis algorithm

随机游走 Metropolis 算法的可扩展耦合

Abstract There has been a recent surge of interest in coupling methods for Markov chain Monte Carlo algorithms: they facilitate convergence quantification and unbiased estimation, while exploiting embarrassingly parallel computing capabilities. Motivated by these, we consider the design and analysis of couplings of the random walk Metropolis algorithm which scale well with the dimension of the target measure. Methodologically, we introduce a low-rank modification of the…

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Adaptive conformal classification with noisy labels

含噪标签的自适应保形分类

Abstract This article develops a conformal prediction method for classification tasks that can adapt to random label contamination in the calibration sample, often leading to more informative prediction sets with stronger coverage guarantees compared to existing approaches. This is obtained through a precise characterization of the coverage inflation (or deflation) suffered by standard conformal inferences in the presence of label contamination, which is then made actionable…

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Robust angle-based transfer learning in high dimensions

高维稳健角度迁移学习

Abstract Transfer learning improves target model performance by leveraging data from related source populations, especially when target data are scarce. This study addresses the challenge of training high-dimensional regression models with limited target data in the presence of heterogeneous source populations. We focus on a practical setting where only parameter estimates of pretrained source models are available, rather than individual-level source data. For a single…

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Robustness, model checking, and hierarchical models

稳健性、模型检验与层级模型

Abstract Model checking is essential to evaluate the adequacy of statistical models and the validity of inferences drawn from them. Particularly, hierarchical models such as latent Gaussian models (LGMs) pose unique challenges as it is difficult to check assumptions on the latent parameters. Diagnostic statistics are often used to quantify the degree to which a model fit deviates from the observed data. We construct diagnostic statistics by (a) defining an alternative model…

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Adaptive functional principal components analysis

自适应函数型主成分分析

Abstract Functional data analysis almost always involves smoothing discrete observations into curves, because they are never observed in continuous time and rarely without error. Although smoothing parameters affect the subsequent inference, data-driven methods for selecting these parameters are not well-developed, frustrated by the difficulty of using all the information shared by curves while being computationally efficient. On the one hand, smoothing individual curves in…

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Causal mediation analysis: selection with asymptotically valid inference

因果中介分析:选择与渐近有效推断

Abstract Researchers are often interested in learning not only the effect of treatments on outcomes, but also the mechanisms that transmit these effects. A mediator is a variable that is affected by treatment and subsequently affects outcome. Existing methods for penalized mediation analyses may lead to ignoring important mediators and either assume that finite-dimensional linear models are sufficient to remove confounding bias, or perform no confounding control at all. In…

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Engression: extrapolation through the lens of distributional regression

Engression:从分布回归视角研究外推

Abstract Distributional regression aims to estimate the full conditional distribution of a target variable, given covariates. Popular methods include linear and tree ensemble based quantile regression. We propose a neural network-based distributional regression methodology called ‘engression’. An engression model is generative in the sense that we can sample from the fitted conditional distribution and is also suitable for high-dimensional outcomes. Furthermore, we find that…

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Frequentist inference for semi-mechanistic epidemic models with interventions

含干预的半机制流行病模型:频率学派推断

Abstract The effect of public health interventions on an epidemic are often estimated by adding the intervention to epidemic models. During the Covid-19 epidemic, numerous papers used such methods for making scenario predictions. The majority of these papers use Bayesian methods to estimate the parameters of the model. In this article, we show how to use frequentist methods for estimating these effects which avoids having to specify prior distributions. We also use…

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X-vine models for multivariate extremes

多元极端事件的 X-vine 模型

Abstract Regular vine sequences permit the organization of variables in a random vector along a sequence of trees. Vine-based dependence models have become greatly popular as a way to combine arbitrary bivariate copulas into higher-dimensional ones, offering flexibility, parsimony, and tractability. In this project, we use regular vine sequences to decompose and construct the exponent measure density of a multivariate extreme value distribution, or, equivalently, the tail…

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No Free Lunch? Welfare Analysis of Firms Selling Through Expert Intermediaries

没有免费午餐?经由专家中介销售企业的福利分析

Abstract We study how firms target and influence expert intermediaries. In our context, pharmaceutical manufacturers provide payments to physicians during promotional interactions. We develop an identification strategy based on plausibly exogenous variation in payments driven by differential exposure to spillovers from AMC CoI policies. Using a case study of an important class of cardiovascular drugs, we estimate heterogeneous effects of payments on prescribing, with firms…

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