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Power-Enhanced Simultaneous Test of High-Dimensional Mean Vectors and Covariance Matrices with Application to Gene-Set Testing

高维均值向量与协方差矩阵的功效增强联合检验及基因集应用

Power-enhanced tests with high-dimensional data have received growing attention in theoretical and applied statistics in recent years. Existing tests possess their respective high-power regions, and we may lack prior knowledge about the alternatives when testing for a problem of interest in practice. There is a critical need of developing powerful testing procedures against more general alternatives. This article studies the joint test of two-sample mean vectors and…

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Model-Free Conditional Feature Screening with FDR Control

控制错误发现率的无模型条件特征筛选

In this article, we propose a model-free conditional feature screening method with false discovery rate (FDR) control for ultra-high dimensional data. The proposed method is built upon a new measure of conditional independence. Thus, the new method does not require a specific functional form of the regression function and is robust to heavy-tailed responses and predictors. The variables to be conditional on are allowed to be multivariate. The proposed method enjoys sure…

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Generalized Low-Rank Plus Sparse Tensor Estimation by Fast Riemannian Optimization

快速黎曼优化下的广义低秩加稀疏张量估计

We investigate a generalized framework to estimate a latent low-rank plus sparse tensor, where the low-rank tensor often captures the multi-way principal components and the sparse tensor accounts for potential model mis-specifications or heterogeneous signals that are unexplainable by the low-rank part. The framework flexibly covers both linear and generalized linear models, and can easily handle continuous or categorical variables. We propose a fast algorithm by integrating…

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Random Surface Covariance Estimation by Shifted Partial Tracing

通过移位部分迹估计随机曲面的协方差

The problem of covariance estimation for replicated surface-valued processes is examined from the functional data analysis perspective. Considerations of statistical and computational efficiency often compel the use of separability of the covariance, even though the assumption may fail in practice. We consider a setting where the covariance structure may fail to be separable locally—either due to noise contamination or due to the presence of a nonseparable short-range…

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Bayesian Modeling of Sequential Discoveries

序贯新发现的贝叶斯建模

We aim at modeling the appearance of distinct tags in a sequence of labeled objects. Common examples of this type of data include words in a corpus or distinct species in a sample. These sequential discoveries are often summarized via accumulation curves, which count the number of distinct entities observed in an increasingly large set of objects. We propose a novel Bayesian method for species sampling modeling by directly specifying the probability of a new discovery,…

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Metropolis–Hastings via Classification

通过分类实现 Metropolis–Hastings 后验采样

This article develops a Bayesian computational platform at the interface between posterior sampling and optimization in models whose marginal likelihoods are difficult to evaluate. Inspired by contrastive learning and Generative Adversarial Networks (GAN), we reframe the likelihood function estimation problem as a classification problem. Pitting a Generator, who simulates fake data, against a Classifier, who tries to distinguish them from the real data, one obtains…

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Distribution-Free Prediction Sets for Two-Layer Hierarchical Models

双层层级模型的分布无关预测集

We consider the problem of constructing distribution-free prediction sets for data from two-layer hierarchical distributions. For iid data, prediction sets can be constructed using the method of conformal prediction. The validity of conformal prediction hinges on the exchangeability of the data, which does not hold when groups of observations come from distinct distributions, such as multiple observations on each patient in a medical database. We extend conformal methods to…

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Prior-Preconditioned Conjugate Gradient Method for Accelerated Gibbs Sampling in “Large n , Large p ” Bayesian Sparse Regression

以先验预条件共轭梯度法加速大样本高维贝叶斯稀疏回归的 Gibbs 抽样

In a modern observational study based on healthcare databases, the number of observations and of predictors typically range in the order of 10^{5}-10^{6} and of 10^{4}-10^{5}. Despite the large sample size, data rarely provide sufficient information to reliably estimate such a large number of parameters. Sparse regression techniques provide potential solutions, one notable approach being the Bayesian method based on shrinkage priors. In the "large n and large p" setting,…

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Sharp Nonparametric Bounds for Decomposition Effects with Two Binary Mediators

两个二元中介下分解效应的尖锐非参数界限

In randomized trials, once the total effect of the intervention has been estimated, it is often of interest to explore mechanistic effects through mediators along the causal pathway between the randomized treatment and the outcome. In the setting with two sequential mediators, there are a variety of decompositions of the total risk difference into mediation effects. We derive sharp and valid bounds for a number of mediation effects in the setting of two sequential mediators…

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Efficient Estimation in the Fine and Gray Model

Fine–Gray 模型中的有效估计

Direct regression for the cumulative incidence function (CIF) has become increasingly popular since the Fine and Gray model was suggested (Fine and Gray) due to its more direct interpretation on the probability risk scale. We here consider estimation within the Fine and Gray model using the theory of semiparametric efficient estimation. We show that the Fine and Gray estimator is semiparametrically efficient in the case without censoring. In the case of right-censored data,…

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Bias-Adjusted Spectral Clustering in Multi-Layer Stochastic Block Models

多层随机块模型中的偏差校正谱聚类

We consider the problem of estimating common community structures in multi-layer stochastic block models, where each single layer may not have sufficient signal strength to recover the full community structure. In order to efficiently aggregate signal across different layers, we argue that the sum-of-squared adjacency matrices contain sufficient signal even when individual layers are very sparse. Our method uses a bias-removal step that is necessary when the squared noise…

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A General Pairwise Comparison Model for Extremely Sparse Networks

极稀疏网络的一般成对比较模型

Statistical estimation using pairwise comparison data is an effective approach to analyzing large-scale sparse networks. In this article, we propose a general framework to model the mutual interactions in a network, which enjoys ample flexibility in terms of model parameterization. Under this setup, we show that the maximum likelihood estimator for the latent score vector of the subjects is uniformly consistent under a near-minimal condition on network sparsity. This…

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Sparse Reduced Rank Huber Regression in High Dimensions

高维稀疏降秩 Huber 回归

We propose a sparse reduced rank Huber regression for analyzing large and complex high-dimensional data with heavy-tailed random noise. The proposed method is based on a convex relaxation of a rank- and sparsity-constrained nonconvex optimization problem, which is then solved using a block coordinate descent and an alternating direction method of multipliers algorithm. We establish nonasymptotic estimation error bounds under both Frobenius and nuclear norms in the…

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Survival Analysis via Ordinary Differential Equations

基于常微分方程的生存分析

This article introduces an Ordinary Differential Equation (ODE) notion for survival analysis. The ODE notion not only provides a unified modeling framework, but more importantly, also enables the development of a widely applicable, scalable, and easy-to-implement procedure for estimation and inference. Specifically, the ODE modeling framework unifies many existing survival models, such as the proportional hazards model, the linear transformation model, the accelerated…

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Robust Estimation of Large Panels with Factor Structures

具有因子结构的大型面板的稳健估计

This article studies estimation of linear panel regression models with heterogeneous coefficients using a class of weighted least squares estimators, when both the regressors and the error possibly contain a common latent factor structure. Our theory is robust to the specification of such a factor structure because it does not require any information on the number of factors or estimation of the factor structure itself. Moreover, our theory is efficient, in certain…

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Toward Better Practice of Covariate Adjustment in Analyzing Randomized Clinical Trials

随机临床试验中协变量调整的实践改进

In randomized clinical trials, adjustments for baseline covariates at both design and analysis stages are highly encouraged by regulatory agencies. A recent trend is to use a model-assisted approach for covariate adjustment to gain credibility and efficiency while producing asymptotically valid inference even when the model is incorrect. In this article we present three considerations for better practice when model-assisted inference is applied to adjust for covariates under…

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Marginal and Conditional Multiple Inference for Linear Mixed Model Predictors

线性混合模型预测量的边际与条件多重推断

In spite of its high practical relevance, cluster specific multiple inference for linear mixed model predictors has hardly been addressed so far. While marginal inference for population parameters is well understood, conditional inference for the cluster specific predictors is more intricate. This work introduces a general framework for multiple inference in linear mixed models for cluster specific predictors. Consistent confidence sets for multiple inference are constructed…

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Understanding Implicit Regularization in Over-Parameterized Single Index Model

过参数化单指标模型中的隐式正则化

In this paper, we leverage over-parameterization to design regularization-free algorithms for the high-dimensional single index model and provide theoretical guarantees for the induced implicit regularization phenomenon. Specifically, we study both vector and matrix single index models where the link function is nonlinear and unknown, the signal parameter is either a sparse vector or a low-rank symmetric matrix, and the response variable can be heavy-tailed. To gain a better…

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A Zero-Inflated Logistic Normal Multinomial Model for Extracting Microbial Compositions

用于提取微生物组成的零膨胀逻辑正态多项模型

High throughput sequencing data collected to study the microbiome provide information in the form of relative abundances and should be treated as compositions. Although many approaches including scaling and rarefaction have been proposed for converting raw count data into microbial compositions, most of these methods simply return zero values for zero counts. However, zeros can distort downstream analyses, and they can also pose problems for composition-aware methods. This…

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Discussion of Levon Barseghyan and Francesca Molinari’s “Risk Preference Types, Limited Consideration, and Welfare”

评《风险偏好类型、有限考虑与福利》

1 It’s a pleasure to discuss this article, which estimates risk preferences from observational data while accommodating heterogeneity across three dimensions of choice: consideration sets, risk pre...

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Context-Dependent Heterogeneous Preferences: A Comment on Barseghyan and Molinari (2023)

情境依赖的异质偏好:对 Barseghyan 与 Molinari(2023)的评论

–Barseghyan and Molinari give sufficient conditions for semi-nonparametric point identification of parameters of interest in a mixture model of decision-making under risk, allowing for unobserved heterogeneity in utility functions and limited consideration. A key assumption in the model is that the heterogeneity of risk preferences is unobservable but context-independent. In this comment, we build on their insights and present identification results in a setting where the…

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Risk Preference Types, Limited Consideration, and Welfare

风险偏好类型、有限考虑与福利

We provide sufficient conditions for semi-nonparametric point identification of a mixture model of decision making under risk, when agents make choices in multiple lines of insurance coverage (contexts) by purchasing a bundle. As a first departure from the related literature, the model allows for two preference types. In the first one, agents behave according to standard expected utility theory with CARA Bernoulli utility function, with an agent-specific coefficient of…

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Fast Variational Bayes Methods for Multinomial Probit Models

多项 Probit 模型的快速变分贝叶斯方法

The multinomial probit model is often used to analyze choice behavior. However, estimation with existing Markov chain Monte Carlo (MCMC) methods is computationally costly, which limits its applicability to large choice datasets. This article proposes a variational Bayes method that is accurate and fast, even when a large number of choice alternatives and observations are considered. Variational methods usually require an analytical expression for the unnormalized posterior…

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