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Multi-Task Learning with High-Dimensional Noisy Images

含噪高维影像的多任务学习

Recent medical imaging studies have given rise to distinct but inter-related datasets corresponding to multiple experimental tasks or longitudinal visits. Standard scalar-on-image regression models that fit each dataset separately are not equipped to leverage information across inter-related images, and existing multi-task learning approaches are compromised by the inability to account for the noise that is often observed in images. We propose a novel joint scalar-on-image…

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Anomaly Detection for a Large Number of Streams: A Permutation-Based Higher Criticism Approach

大量数据流的异常检测:基于置换的高批评统计量方法

Anomaly detection when observing a large number of data streams is essential in a variety of applications, ranging from epidemiological studies to monitoring of complex systems. High-dimensional scenarios are usually tackled with scan-statistics and related methods, requiring stringent modeling assumptions for proper calibration. In this work we take a nonparametric stance, and propose a permutation-based variant of the higher criticism statistic not requiring knowledge of…

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Bootstrapping Extreme Value Estimators

极值估计量的自助法

This article develops a bootstrap analogue of the well-known asymptotic expansion of the tail quantile process in extreme value theory. One application of this result is to construct confidence intervals for estimators of the extreme value index such as the Probability Weighted Moment (PWM) estimator. For the peaks-over-threshold method, we show the bootstrap consistency of the confidence intervals. By contrast, the asymptotic expansion of the quantile process of the…

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Estimating Optimal Infinite Horizon Dynamic Treatment Regimes via pT-Learning

通过 pT-Learning 估计无限期最优动态治疗方案

Recent advances in mobile health (mHealth) technology provide an effective way to monitor individuals’ health statuses and deliver just-in-time personalized interventions. However, the practical use of mHealth technology raises unique challenges to existing methodologies on learning an optimal dynamic treatment regime. Many mHealth applications involve decision-making with large numbers of intervention options and under an infinite time horizon setting where the number of…

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A Mass-Shifting Phenomenon of Truncated Multivariate Normal Priors

截断多元正态先验的概率质量偏移现象

We show that lower-dimensional marginal densities of dependent zero-mean normal distributions truncated to the positive orthant exhibit a mass-shifting phenomenon. Despite the truncated multivariate normal density having a mode at the origin, the marginal density assigns increasingly small mass near the origin as the dimension increases. The phenomenon accentuates with stronger correlation between the random variables. This surprising behavior has serious implications toward…

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Estimating the Spectral Density at Frequencies Near Zero

零频率附近的谱密度估计

Estimating the spectral density function f(w) for some w∈[−π,π] has been traditionally performed by kernel smoothing the periodogram and related techniques. Kernel smoothing is tantamount to local averaging, that is, approximating f(w) by a constant over a window of small width. Although f(w) is uniformly continuous and periodic with period 2π, in this article we recognize the fact that w = 0 effectively acts as a boundary point in the underlying kernel smoothing problem,…

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Distribution of Distances based Object Matching: Asymptotic Inference

基于距离分布的对象匹配:渐近推断

In this article, we aim to provide a statistical theory for object matching based on a lower bound of the Gromov-Wasserstein distance related to the distribution of (pairwise) distances of the considered objects. To this end, we model general objects as metric measure spaces. Based on this, we propose a simple and efficiently computable asymptotic statistical test for pose invariant object discrimination. This is based on a (β-trimmed) empirical version of the…

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Inference in Heavy-Tailed Nonstationary Multivariate Time Series

重尾非平稳多元时间序列中的推断

We study inference on the common stochastic trends in a non-stationary, $N$-variate time series $y_{t}$, in the possible presence of heavy tails. We propose a novel methodology which does not require any knowledge or estimation of the tail index, or even knowledge as to whether certain moments (such as the variance) exist or not, and develop an estimator of the number of stochastic trends $m$ based on the eigenvalues of the sample second moment matrix of $y_{t}$. We study…

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Fisher-Pitman Permutation Tests Based on Nonparametric Poisson Mixtures with Application to Single Cell Genomics

基于非参数泊松混合的 Fisher–Pitman 置换检验及其单细胞基因组学应用

This article investigates the theoretical and empirical performance of Fisher-Pitman-type permutation tests for assessing the equality of unknown Poisson mixture distributions. Building on nonparametric maximum likelihood estimators (NPMLEs) of the mixing distribution, these tests are theoretically shown to be able to adapt to complicated unspecified structures of count data and also consistent against their corresponding ANOVA-type alternatives; the latter is a result in…

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Policy Optimization Using Semiparametric Models for Dynamic Pricing

In this paper, we study the contextual dynamic pricing problem where the market value of a product is linear in its observed features plus some market noise. Products are sold one at a time, and only a binary response indicating success or failure of a sale is observed. Our model setting is similar to Javanmard and Nazerzadeh [2019] except that we expand the demand curve to a semiparametric model and need to learn dynamically both parametric and nonparametric components. We…

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An Algebraic Estimator for Large Spectral Density Matrices

高维谱密度矩阵的代数估计量

We propose a new estimator of high-dimensional spectral density matrices, called UNshrunk ALgebraic Spectral Estimator (UNALSE), under the assumption of an underlying low rank plus sparse structure, as typically assumed in dynamic factor models. The UNALSE is computed by minimizing a quadratic loss under a nuclear norm plus $l_1$ norm constraint to control the latent rank and the residual sparsity pattern. The loss function requires as input the classical smoothed…

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Fisher’s Combined Probability Test for High-Dimensional Covariance Matrices

高维协方差矩阵的Fisher合并概率检验

Testing large covariance matrices is of fundamental importance in statistical analysis with high-dimensional data. In the past decade, three types of test statistics have been studied in the literature: quadratic form statistics, maximum form statistics, and their weighted combination. It is known that quadratic form statistics would suffer from low power against sparse alternatives and maximum form statistics would suffer from low power against dense alternatives. The…

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Assumption-Lean Cox Regression

弱模型假设下的Cox回归

Inference for the conditional association between an exposure and a time-to-event endpoint, given covariates, is routinely based on partial likelihood estimators for hazard ratios indexing Cox proportional hazards models. This approach is flexible and makes testing straightforward, but is nonetheless not entirely satisfactory. First, there is no good understanding of what it infers when the model is misspecified. Second, it is common to employ variable selection procedures…

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To Adjust or not to Adjust? Estimating the Average Treatment Effect in Randomized Experiments with Missing Covariates

调整还是不调整?协变量缺失时随机实验平均处理效应的估计

Complete randomization allows for consistent estimation of the average treatment effect based on the difference in means of the outcomes without strong modeling assumptions on the outcome-generating process. Appropriate use of the pretreatment covariates can further improve the estimation efficiency. However, missingness in covariates is common in experiments and raises an important question: should we adjust for covariates subject to missingness, and if so, how? The…

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An Additive Graphical Model for Discrete Data

离散数据的加性图模型

We introduce a nonparametric graphical model for discrete node variables based on additive conditional independence. Additive conditional independence is a three-way statistical relation that shares similar properties with conditional independence by satisfying the semi-graphoid axioms. Based on this relation we build an additive graphical model for discrete variables that does not suffer from the restriction of a parametric model such as the Ising model. We develop an…

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Selective Inference for Hierarchical Clustering

层次聚类的选择后推断

Classical tests for a difference in means control the Type I error rate when the groups are defined a priori. However, when the groups are instead defined via clustering, then applying a classical test yields an extremely inflated Type I error rate. Notably, this problem persists even if two separate and independent datasets are used to define the groups and to test for a difference in their means. To address this problem, in this article, we propose a selective inference…

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Using SVD for Topic Modeling

利用奇异值分解进行主题建模

The probabilistic topic model imposes a low-rank structure on the expectation of the corpus matrix. Therefore, singular value decomposition (SVD) is a natural tool of dimension reduction. We propose an SVD-based method for estimating a topic model. Our method constructs an estimate of the topic matrix from only a few leading singular vectors of the data matrix, and has a great advantage in memory use and computational cost for large-scale corpora. The core ideas behind our…

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Fast and Numerically Stable Particle-Based Online Additive Smoothing: The AdaSmooth Algorithm

快速且数值稳定的粒子在线加性平滑:AdaSmooth 算法

We present a novel sequential Monte Carlo approach to online smoothing of additive functionals in a very general class of path-space models. Hitherto, the solutions proposed in the literature suffer from either long-term numerical instability due to particle-path degeneracy or, in the case that degeneracy is remedied by particle approximation of the so-called backward kernel, high computational demands. In order to balance optimally computational speed against numerical…

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Subspace Estimation with Automatic Dimension and Variable Selection in Sufficient Dimension Reduction

充分降维中兼具自动维数与变量选择的子空间估计

Sufficient dimension reduction (SDR) methods target finding lower-dimensional representations of a multivariate predictor to preserve all the information about the conditional distribution of the response given the predictor. The reduction is commonly achieved by projecting the predictor onto a low-dimensional subspace. The smallest such subspace is known as the Central Subspace (CS) and is the key parameter of interest for most SDR methods. In this article, we propose a…

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Dynamic Principal Component Analysis in High Dimensions

高维动态主成分分析

Principal component analysis is a versatile tool to reduce dimensionality which has wide applications in statistics and machine learning. It is particularly useful for modeling data in high-dimensional scenarios where the number of variables p is comparable to, or much larger than the sample size n. Despite an extensive literature on this topic, researchers have focused on modeling static principal eigenvectors, which are not suitable for stochastic processes that are…

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Optimal One-Pass Nonparametric Estimation Under Memory Constraint

内存约束下最优的单遍非参数估计

For nonparametric regression in the streaming setting, where data constantly flow in and require real-time analysis, a main challenge is that data are cleared from the computer system once processed due to limited computer memory and storage. We tackle the challenge by proposing a novel one-pass estimator based on penalized orthogonal basis expansions and developing a general framework to study the interplay between statistical efficiency and memory consumption of…

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Optimal Nonparametric Inference with Two-Scale Distributional Nearest Neighbors

基于双尺度分布近邻的最优非参数推断

The weighted nearest neighbors (WNN) estimator has been popularly used as a flexible and easy-to-implement nonparametric tool for mean regression estimation. The bagging technique is an elegant way to form WNN estimators with weights automatically generated to the nearest neighbors (Steele, 2009; Biau et al., 2010); we name the resulting estimator as the distributional nearest neighbors (DNN) for easy reference. Yet, there is a lack of distributional results for such…

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Off-Policy Confidence Interval Estimation with Confounded Markov Decision Process

存在混杂的马尔可夫决策过程中的离线策略价值置信区间估计

This article is concerned with constructing a confidence interval for a target policy’s value offline based on a pre-collected observational data in infinite horizon settings. Most of the existing works assume no unmeasured variables exist that confound the observed actions. This assumption, however, is likely to be violated in real applications such as healthcare and technological industries. In this article, we show that with some auxiliary variables that mediate the…

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Scaled Process Priors for Bayesian Nonparametric Estimation of the Unseen Genetic Variation

用于未观测遗传变异估计的贝叶斯非参数缩放过程先验

There is a growing interest in the estimation of the number of unseen features, mostly driven by biological applications. A recent work brought out a peculiar property of the popular completely random measures (CRMs) as prior models in Bayesian nonparametric (BNP) inference for the unseen-features problem: for fixed prior's parameters, they all lead to a Poisson posterior distribution for the number of unseen features, which depends on the sampling information only through…

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