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Additive hazards Markov regression models illustrated with bone marrow transplant data

加性风险 Markov 回归模型及骨髓移植数据示例

When there are covariate effects to be considered, multi-state survival analysis is dominated either by parametric Markov regression models or by semiparametric Markov regression models using Cox's (1972) proportional hazards models for transition intensities between the states. The purpose of this research work is to study alternatives to Cox's model in a general finite-state Markov process setting. We shall look at two alternative models, Aalen's (1989) nonparametric…

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Empirical-likelihood-based semiparametric inference for the treatment effect in the two-sample problem with censoring

删失两样本问题中治疗效应的经验似然半参数推断

To compare two samples of censored data, we propose a unified semiparametric inference for the parameter of interest when the model for one sample is parametric and that for the other is nonparametric. The parameter of interest may represent, for example, a comparison of means, or survival probabilities. The confidence interval derived from the semiparametric inference, which is based on the empirical likelihood principle, improves its counterpart constructed from the common…

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Semiparametric maximum likelihood estimation exploiting gene-environment independence in case-control studies

利用基因与环境独立性的病例对照半参数最大似然估计

We consider the problem of maximum-likelihood estimation in case-control studies of gene-environment associations with disease when genetic and environmental exposures can be assumed to be independent in the underlying population. Traditional logistic regression analysis may not be efficient in this setting. We study the semiparametric maximum likelihood estimates of logistic regression parameters that exploit the gene-environment independence assumption and leave the…

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Marginal likelihood, conditional likelihood and empirical likelihood: Connections and applications

边际似然、条件似然与经验似然的联系及应用

Marginal likelihood and conditional likelihood are often used for eliminating nuisance parameters. For a parametric model, it is well known that the full likelihood can be decomposed into the product of a conditional likelihood and a marginal likelihood. This property is less transparent in a nonparametric or semiparametric likelihood setting. In this paper we show that this nice parametric likelihood property can be carried over to the empirical likelihood world. We discuss…

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Bandwidth selection for smooth backfitting in additive models

加性模型平滑回拟合的带宽选择

The smooth backfitting introduced by Mammen, Linton and Nielsen [Ann. Statist. 27 (1999) 1443–1490] is a promising technique to fit additive regression models and is known to achieve the oracle efficiency bound. In this paper, we propose and discuss three fully automated bandwidth selection methods for smooth backfitting in additive models. The first one is a penalized least squares approach which is based on higher-order stochastic expansions for the residual sums of…

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Bayesian Semiparametric Isotonic Regression for Count Data

计数数据的贝叶斯半参数保序回归

This article proposes a semiparametric Bayesian approach for inference on an unknown isotonic regression function, f(x), characterizing the relationship between a continuous predictor, X, and a count response variable, Y, adjusting for covariates, Z. A Dirichlet process mixture of Poisson distributions is used to avoid parametric assumptions on the conditional distribution of Y given X and Z. Then, to also avoid parametric assumptions on f(x), a novel prior formulation is…

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Semiparametric Bayesian Analysis of Matched Case-Control Studies With Missing Exposure

暴露缺失时匹配病例对照研究的半参数贝叶斯分析

This article considers Bayesian analysis of matched case-control problems when one of the covariates is partially missing. Within the likelihood context, the standard approach to this problem is to posit a fully parametric model among the controls for the partially missing covariate as a function of the covariates in the model and the variables making up the strata. Sometimes the strata effects are ignored at this stage. Our approach differs not only in that it is Bayesian,…

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Maximum Likelihood Estimation for the Proportional Odds Model With Random Effects

含随机效应的比例优势模型最大似然估计

In this article we study the semiparametric proportional odds model with random effects for correlated, right-censored failure time data. We establish that the maximum likelihood estimators for the parameters of this model are consistent and asymptotically Gaussian. Furthermore, the limiting variances achieve the semiparametric efficiency bounds and can be consistently estimated. Simulation studies show that the asymptotic approximations are accurate for practical sample…

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The Bootstrap and the Edgeworth Correction for Semiparametric Averaged Derivatives*

半参数平均导数的 Bootstrap 与 Edgeworth 修正

In a number of semiparametric models, smoothing seems necessary in order to obtain estimates of the parametric component which are asymptotically normal and converge at parametric rate. However, smoothing can inflate the error in the normal approximation, so that refined approximations are of interest, especially in sample sizes that are not enormous. We show that a bootstrap distribution achieves a valid Edgeworth correction in the case of density-weighted averaged…

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Estimating Semiparametric ARCH(oo) Models by Kernel Smoothing Methods1

利用核平滑方法估计半参数 ARCH(∞) 模型

We investigate a class of semiparametric ARCH(∞) models that includes as a special case the partially nonparametric (PNP) model introduced by Engle and Ng (1993) and which allows for both flexible dynamics and flexible function form with regard to the “news impact” function. We show that the functional part of the model satisfies a type II linear integral equation and give simple conditions under which there is a unique solution. We propose an estimation method that is based…

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Structural Equations, Treatment Effects, and Econometric Policy Evaluation1

结构方程、处理效应与计量经济政策评估

This paper uses the marginal treatment effect (MTE) to unify the nonparametric literature on treatment effects with the econometric literature on structural estimation using a nonparametric analog of a policy invariant parameter; to generate a variety of treatment effects from a common semiparametric functional form; to organize the literature on alternative estimators; and to explore what policy questions commonly used estimators in the treatment effect literature answer. A…

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Semiparametric estimation of lifetime equivalence scales

终身等价尺度的半参数估计

Abstract Pashardes ( 1991 ) and Banks et al. ( 1994 ) use parametric methods to estimate lifetime equivalence scales. Their approaches put parametric restrictions on the differences in within‐period expenditure needs across household types, the intertemporal allocation of expenditure, and the shapes of commodity demand equations. This paper puts parametric structure only on the differences in within‐period expenditure needs across household types. This implies structure on…

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Likelihood approach for marginal proportional hazards regression in the presence of dependent censoring

相依删失下边际比例风险回归的似然方法

In many public health problems, an important goal is to identify the effect of some treatment/intervention on the risk of failure for the whole population. A marginal proportional hazards regression model is often used to analyze such an effect. When dependent censoring is explained by many auxiliary covariates, we utilize two working models to condense high-dimensional covariates to achieve dimension reduction. Then the estimator of the treatment effect is obtained by…

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Generalized functional linear models

广义函数型线性模型

We propose a generalized functional linear regression model for a regression situation where the response variable is a scalar and the predictor is a random function. A linear predictor is obtained by forming the scalar product of the predictor function with a smooth parameter function, and the expected value of the response is related to this linear predictor via a link function. If, in addition, a variance function is specified, this leads to a functional estimating…

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Semiparametric regression analysis of mean residual life with censored survival data

删失生存数据平均剩余寿命的半参数回归分析

As function of time t, a mean residual life is the remaining life expectancy of a subject given survival up to t. The proportional mean residual life model, proposed by Oakes & Dasu (1990), provides an alternative to the Cox proportional hazards model for studying the association between survival times and covariates. In the presence of censoring, we use counting process theory to develop semiparametric inference procedures for the regression coefficients of the Oakes–Dasu…

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Semiparametric analysis of short-term and long-term hazard ratios with two-sample survival data

两样本生存数据中短期与长期风险比的半参数分析

Standard approaches to semiparametric modelling of two-sample survival data are not appropriate when the two survival curves cross. We introduce a two-sample model that accommodates crossing survival curves. The two scalar parameters of the model have the interpretations of being the short-term and long-term hazard ratios respectively. The time-varying hazard ratio is expressed semiparametrically by the two scalar parameters and an unspecified baseline distribution. The new…

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Efficient Semiparametric Marginal Estimation for Longitudinal/Clustered Data

纵向与聚类数据的有效半参数边际估计

We consider marginal generalized semiparametric partially linear models for clustered data. Lin and Carroll derived the semiparametric efficient score function for this problem in the multivariate Gaussian case, but they were unable to construct a semiparametric efficient estimator that actually achieved the semiparametric information bound. Here we propose such an estimator and generalize the work to marginal generalized partially linear models. We investigate asymptotic…

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A Bayesian Semiparametric Model for Random-Effects Meta-Analysis

随机效应元分析的贝叶斯半参数模型

In meta-analysis, there is an increasing trend to explicitly acknowledge the presence of study variability through random-effects models. That is, one assumes that for each study there is a study-specific effect and one is observing an estimate of this latent variable. In a random-effects model, one assumes that these study-specific effects come from some distribution, and one can estimate the parameters of this distribution, as well as the study-specific effects themselves.…

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Estimating Load-Sharing Properties in a Dynamic Reliability System

动态可靠性系统的负载共享特性估计

An estimator for the load share parameters in an equal load-share model is derived based on observing k-component parallel systems of identical components that have a continuous distribution function F (.) and failure rate r(.). In an equal load share model, after the first of k components fails, failure rates for the remaining components change from r(t) to gamma(1)r(t), then to gamma(2)r(t) after the next failure, and so on. On the basis of observations on n independent…

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Efficient estimation of Banach parameters in semiparametric models

半参数模型中 Banach 参数的有效估计

Consider a semiparametric model with a Euclidean parameter and an infinite-dimensional parameter, to be called a Banach parameter. Assume: (a) There exists an efficient estimator of the Euclidean parameter. (b) When the value of the Euclidean parameter is known, there exists an estimator of the Banach parameter, which depends on this value and is efficient within this restricted model. Substituting the efficient estimator of the Euclidean parameter for the value of this…

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Efficient estimation of a semiparametric partially linear varying coefficient model

半参数部分线性变系数模型的有效估计

In this paper we propose a general series method to estimate a semiparametric partially linear varying coefficient model. We establish the consistency and $\sqrt{n}$-normality property of the estimator of the finite-dimensional parameters of the model. We further show that, when the error is conditionally homoskedastic, this estimator is semiparametrically efficient in the sense that the inverse of the asymptotic variance of the estimator of the finite-dimensional parameter…

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CHALLENGES FOR ECONOMETRIC MODEL SELECTION

计量经济模型选择的挑战

Standard econometric model selection methods are based on four conceptual errors: parametric vision, the assumption of a true data generating process, evaluation based on fit, and ignoring the impact of model uncertainty on inference. Instead, econometric model selection methods should be based on a semiparametric vision, models should be viewed as approximations, models should be evaluated based on their purpose, and model uncertainty should be incorporated into inference…

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Semiparametric Difference-in-Differences Estimators

The difference-in-differences (DID) estimator is one of the most popular tools for applied research in economics to evaluate the effects of public interventions and other treatments of interest on some relevant outcome variables. However, it is well known that the DID estimator is based on strong identifying assumptions. In particular, the conventional DID estimator requires that, in the absence of the treatment, the average outcomes for the treated and control groups would…

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