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协变量随机缺失回归模型的筛极大似然估计AI 解读

Missing covariates are common in regression problems. We propose a new semiparametric method based on a fully nonparametric distribution for the missing covariates that are assumed to be missing at random. The method of sieve maximum likelihood estimation is used to obtain the estimators of the regression coefficients. These estimators are shown to be consistent and asymptotically normal with their asymptotic covariance matrix that achieves the semiparametric efficiency…

扩散加权磁共振成像中扩散张量的统计分析AI 解读

Diffusion tensor imaging has been widely used to reconstruct the structure and orientation of fibers in biological tissues, particularly in the white matter of the brain, because it can track the effective diffusion of water along those fibers. The raw diffusion-weighted images from which diffusion tensors are estimated, however, inherently contain noise. Noise in the images produces uncertainty in the estimation of the tensors (which are 3 × 3 positive-definite matrices)…

多中心生存研究的多分辨率风险模型AI 解读

In multicenter studies, one often needs to make inference about a population survival curve based on multiple, possibly heterogeneous survival data from individual centers. We investigate a flexible Bayesian method for estimating a population survival curve based on a semiparametric multiresolution hazard model that can incorporate covariates and account for center heterogeneity. The method yields a smooth estimate of the survival curve for "multiple resolutions" or time…

加速失效时间模型的有效估计AI 解读

The accelerated failure time model provides a natural formulation of the effects of covariates on potentially censored response variable. The existing semiparametric estimators are computationally intractable and statistically inefficient. In this article we propose an approximate nonparametric maximum likelihood method for the accelerated failure time model with possibly time-dependent covariates. We estimate the regression parameters by maximizing a kernel-smoothed profile…

随机对照试验中他莫昔芬预防乳腺癌效应的推断AI 解读

The largest randomized, double-blind, placebo-controlled chemoprevention trial, the National Surgical Adjuvant Breast and Bowel Project's Breast Cancer Prevention Trial (NSABP-BCPT), evaluated the efficacy of tamoxifen in the prevention of breast cancer among women at high risk of developing the disease. The trial has reported a reduction of breast cancer incidence for the tamoxifen group. However, the effect of tamoxifen on the time to diagnosis of the disease over the…

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随机化后事件发生才观测结局时，给定基线协变量的治疗效应半参数估计AI 解读

Summary We consider estimation, from a double-blind randomized trial, of treatment effect within levels of base-line covariates on an outcome that is measured after a post-treatment event E has occurred in the subpopulation 𝒫E,E that would experience event E regardless of treatment. Specifically, we consider estimation of the parameters γ indexing models for the outcome mean conditional on treatment and base-line covariates in the subpopulation 𝒫E,E. Such parameters are…

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形状不变恩格尔曲线的半非参数工具变量估计AI 解读

This paper studies a shape-invariant Engel curve system with endogenous total expenditure, in which the shape-invariant specification involves a common shift parameter for each demographic group in a pooled system of nonparametric Engel curves. We focus on the identification and estimation of both the nonparametric shapes of the Engel curves and the parametric specification of the demographic scaling parameters. The identification condition relates to the bounded…

迭代估计方程：线性收敛与渐近性质AI 解读

We propose an iterative estimating equations procedure for analysis of longitudinal data. We show that, under very mild conditions, the probability that the procedure converges at an exponential rate tends to one as the sample size increases to infinity. Furthermore, we show that the limiting estimator is consistent and asymptotically efficient, as expected. The method applies to semiparametric regression models with unspecified covariances among the observations. In the…

含协变量面板计数数据的两种基于似然的半参数估计方法AI 解读

We consider estimation in a particular semiparametric regression model for the mean of a counting process with “panel count” data. The basic model assumption is that the conditional mean function of the counting process is of the form E{ℕ(t)|Z}=exp(β0TZ)Λ0(t) where Z is a vector of covariates and Λ0 is the baseline mean function. The “panel count” observation scheme involves observation of the counting process ℕ for an individual at a random number K of random time points;…

平稳分数协整的局部 Whittle 分析及隐含与已实现波动率的关系AI 解读

I consider local Whittle analysis of a stationary fractionally cointegrated model. The local Whittle quasi maximum likelihood estimator is proposed to jointly estimate the integration orders of the regressors, the integration order of the errors, and the cointegration vector. The proposed estimator is semiparametric in the sense that it employs local assumptions on the joint spectral density matrix of the regressors and the errors near the zero frequency. I show that the…

删失数据半参数回归模型中的极大似然估计AI 解读

Summary Semiparametric regression models play a central role in formulating the effects of covariates on potentially censored failure times and in the joint modelling of incomplete repeated measures and failure times in longitudinal studies. The presence of infinite dimensional parameters poses considerable theoretical and computational challenges in the statistical analysis of such models. We present several classes of semiparametric regression models, which extend the…

结果依赖型随访的纵向研究AI 解读

We propose Bayesian parametric and semiparametric partially linear regression methods to analyze the outcome-dependent follow-up data when the random time of a follow-up measurement of an individual depends on the history of both observed longitudinal outcomes and previous measurement times. We begin with the investigation of the simplifying assumptions of Lipsitz, Fitzmaurice, Ibrahim, Gelber, and Lipshultz, and present a new model for analyzing such data by allowing…

利用 MCMC 实现基于估计函数的推断AI 解读

Under a semiparametric or nonparametric setting, inferences about the unknown parameter are often made based on a nonsmooth estimating function. Resampling methods are quite handy for obtaining good approximations to the distribution of the consistent estimator when the estimating equation and its resampled counterparts are not difficult to solve numerically. In this article we propose a simple, flexible procedure that provides such approximations through the standard Markov…

营养流行病学中的结构化测量误差AI 解读

Preterm birth, defined as delivery before 37 completed weeks' gestation, is a leading cause of infant morbidity and mortality. Identifying factors related to preterm delivery is an important goal of public health professionals who wish to identify etiologic pathways to target for prevention. Validation studies are often conducted in nutritional epidemiology in order to study measurement error in instruments that are generally less invasive or less expensive than "gold…

纵向数据的经验似然半参数回归分析AI 解读

A semiparametric regression model for longitudinal data is considered. The empirical likelihood method is used to estimate the regression coefficients and the baseline function, and to construct confidence regions and intervals. It is proved that the maximum empirical likelihood estimator of the regression coefficients achieves asymptotic efficiency and the estimator of the baseline function attains asymptotic normality when a bias correction is made. Two calibrated…

生存分析中可预测性问题的一般处理方法及应用AI 解读

Very often in survival analysis one has to study martingale integrals where the integrand is not predictable and where the counting process theory of martingales is not directly applicable, as for example in nonparametric and semiparametric applications where the integrand is based on a pilot estimate. We call this the predictability issue in survival analysis. The problem has been resolved by approximations of the integrand by predictable functions which have been justified…

单调响应模型的似然推断AI 解读

The behavior of maximum likelihood estimates (MLEs) and the likelihood ratio statistic in a family of problems involving pointwise nonparametric estimation of a monotone function is studied. This class of problems differs radically from the usual parametric or semiparametric situations in that the MLE of the monotone function at a point converges to the truth at rate n1/3 (slower than the usual $\sqrt{n}$ rate) with a non-Gaussian limit distribution. A framework for…

未知误差分布下函数型测量误差模型的半参数估计AI 解读

Summary We consider functional measurement error models where the measurement error distribution is estimated non-parametrically. We derive a locally efficient semiparametric estimator but propose not to implement it owing to its numerical complexity. Instead, a plug-in estimator is proposed, where the measurement error distribution is estimated through non-parametric kernel methods based on multiple measurements. The root n consistency and asymptotic normality of the…

不规则观测下谱密度的半参数估计AI 解读

We propose a semiparametric method for estimating spectral densities of isotropic Gaussian processes with scattered data. The spectral density function (Fourier transform of the covariance function) is modeled as a linear combination of B-splines up to a cutoff frequency and, from this point, a truncated algebraic tail. We calculate an analytic expression for the covariance function and tackle several numerical issues that arise when calculating the likelihood. The…