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Using shared genetic controls in studies of gene-environment interactions

基因与环境交互作用研究中共享遗传对照的使用

With the advent of modern genomic methods to adjust for population stratification, the use of external or publicly available controls has become an attractive option for reducing the cost of large-scale case-control genetic association studies. In this article, we study the estimation of joint effects of genetic and environmental exposures from a case-control study where data on genome-wide markers are available on the cases and a set of external controls while data on…

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Efficient estimation of the censored linear regression model

删失线性回归模型的有效估计

In linear regression or accelerated failure time models, complications in efficient estimation arise from the multiple roots of the efficient score and density estimation. This paper proposes a one-step efficient estimation method based on a counting process martingale, which has several advantages: it avoids the multiple-root problem, the initial estimator is easily available and the variance estimator can be obtained by employing plug-in rules. A simple and effective…

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Optimal convergence rates, Bahadur representation, and asymptotic normality of partitioning estimators

分割估计量的最优收敛速度、Bahadur 表示与渐近正态性

This paper studies the asymptotic properties of partitioning estimators of the conditional expectation function and its derivatives. Mean-square and uniform convergence rates are established and shown to be optimal under simple and intuitive conditions. The uniform rate explicitly accounts for the effect of moment assumptions, which is useful in semiparametric inference. A general asymptotic integrated mean-square error approximation is obtained and used to derive an optimal…

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Inference on an extended Roy model, with an application to schooling decisions in France

扩展 Roy 模型的推断及其在法国教育选择中的应用

This paper considers the identification and estimation of an extension of Roy’s model (1951) of sectoral choice, which includes a non-pecuniary component in the selection equation and allows for uncertainty on potential earnings. We focus on the identification of the non-pecuniary component, which is key to disentangling the relative importance of monetary incentives versus preferences in the context of sorting across sectors. By making the most of the structure of the…

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Bayesian Hierarchical Poisson Regression Models: An Application to a Driving Study With Kinematic Events

贝叶斯层次泊松回归:青少年驾驶运动学事件研究

Although there is evidence that teenagers are at a high risk of crashes in the early months after licensure, the driving behavior of these teenagers is not well understood. The Naturalistic Teenage Driving Study (NTDS) is the first U.S. study to document continuous driving performance of newly-licensed teenagers during their first 18 months of licensure. Counts of kinematic events such as the number of rapid accelerations are available for each trip, and their incidence…

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Bayesian Gaussian Copula Factor Models for Mixed Data

混合数据的贝叶斯高斯 Copula 因子模型

Gaussian factor models have proven widely useful for parsimoniously characterizing dependence in multivariate data. There is a rich literature on their extension to mixed categorical and continuous variables, using latent Gaussian variables or through generalized latent trait models acommodating measurements in the exponential family. However, when generalizing to non-Gaussian measured variables the latent variables typically influence both the dependence structure and the…

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SEMIPARAMETRIC FUNCTIONAL COEFFICIENT MODELS WITH INTEGRATED COVARIATES

含单整协变量的半参数函数系数模型

Abstract Cai, Li, and Park ( Journal of Econometrics , 2009) and Xiao ( Journal of Econometrics , 2009) developed asymptotic theories for estimators of semiparametric varying coefficient models when regressors are integrated processes but the smooth coefficients are functionals of stationary processes. Using a recent result from Phillips ( Econometric Theory , 2009), we extend this line of research by allowing for both the regressors and the covariates entering the smooth…

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Categorical semiparametric varying‐coefficient models

类别型半参数变系数模型

SUMMARY Semiparametric varying‐coefficient models have become a common fixture in applied data analysis. Existing approaches, however, presume that those variables affecting the coefficients are continuous in nature (or that there exists at least one such continuous variable) which is often not the case. Furthermore, when all variables affecting the coefficients are categorical/discrete, theoretical underpinnings cannot be obtained as a special case of existing approaches…

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ESTIMATION OF BINARY CHOICE MODELS WITH LINEAR INDEX AND DUMMY ENDOGENOUS VARIABLES

含二元内生变量的线性指数二元选择模型估计

This paper presents computationally simple estimators for the index coefficients in a binary choice model with a binary endogenous regressor without relying on distributional assumptions or on large support conditions and yields root- n consistent and asymptotically normal estimators. We develop a multistep method for estimating the parameters in a triangular, linear index, threshold-crossing model with two equations. Such an econometric model might be used in testing for…

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SEMIPARAMETRIC STRUCTURAL MODELS OF BINARY RESPONSE: SHAPE RESTRICTIONS AND PARTIAL IDENTIFICATION

二元响应半参数结构模型:形状限制与部分识别

I study the partial identifying power of structural single-equation threshold-crossing models for binary responses when explanatory variables may be endogenous. The sharp identified set of threshold functions is derived for the case in which explanatory variables are discrete, and I provide a constructive proof of sharpness. There is special attention to a widely employed semiparametric shape restriction, which requires the threshold-crossing function to be a monotone…

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Semi-parametric estimation of American option prices

美式期权价格的半参数估计

We introduce a novel semi-parametric estimator of American option prices in discrete time. The specification is based on a parameterized stochastic discount factor and is nonparametric w.r.t. the historical dynamics of the Markovian state variables. The historical transition density estimator minimizes a distance built on the Kullback–Leibler divergence from a kernel transition density, subject to the no-arbitrage restrictions for a non-defaultable bond, the underlying asset…

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Nonparametric Identification and Semiparametric Estimation of Classical Measurement Error Models Without Side Information

无辅助信息的经典测量误差模型:非参数识别与半参数估计

Virtually all methods aimed at correcting for covariate measurement error in regressions rely on some form of additional information (e.g., validation data, known error distributions, repeated measurements, or instruments). In contrast, we establish that the fully nonparametric classical errors-in-variables model is identifiable from data on the regressor and the dependent variable alone, unless the model takes a very specific parametric form. This parametric family includes…

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A Unified Approach to Semiparametric Transformation Models Under General Biased Sampling Schemes

一般有偏抽样下半参数变换模型的统一方法

We propose a unified estimation method for semiparametric linear transformation models under general biased sampling schemes. The new estimator is obtained from a set of counting process-based unbiased estimating equations, developed through introducing a general weighting scheme that offsets the sampling bias. The usual asymptotic properties, including consistency and asymptotic normality, are established under suitable regularity conditions. A closed-form formula is…

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On Partial Sufficient Dimension Reduction With Applications to Partially Linear Multi-Index Models

部分充分降维及其在部分线性多指标模型中的应用

Partial dimension reduction is a general method to seek informative convex combinations of predictors of primary interest, which includes dimension reduction as its special case when the predictors in the remaining part are constants. In this article, we propose a novel method to conduct partial dimension reduction estimation for predictors of primary interest without assuming that the remaining predictors are categorical. To this end, we first take the dichotomization step…

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Weighted likelihood estimation under two-phase sampling

两阶段抽样下的加权似然估计

We develop asymptotic theory for weighted likelihood estimators (WLE) under two-phase stratified sampling without replacement. We also consider several variants of WLEs involving estimated weights and calibration. A set of empirical process tools are developed including a Glivenko–Cantelli theorem, a theorem for rates of convergence of $M$-estimators, and a Donsker theorem for the inverse probability weighted empirical processes under two-phase sampling and sampling without…

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Efficient estimation in sufficient dimension reduction

充分降维中的有效估计

We develop an efficient estimation procedure for identifying and estimating the central subspace. Using a new way of parameterization, we convert the problem of identifying the central subspace to the problem of estimating a finite dimensional parameter in a semiparametric model. This conversion allows us to derive an efficient estimator which reaches the optimal semiparametric efficiency bound. The resulting efficient estimator can exhaustively estimate the central subspace…

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Quantile-adaptive model-free variable screening for high-dimensional heterogeneous data

高维异质数据的分位数自适应无模型变量筛选

We introduce a quantile-adaptive framework for nonlinear variable screening with high-dimensional heterogeneous data. This framework has two distinctive features: (1) it allows the set of active variables to vary across quantiles, thus making it more flexible to accommodate heterogeneity; (2) it is model-free and avoids the difficult task of specifying the form of a statistical model in a high dimensional space. Our nonlinear independence screening procedure employs spline…

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One-step R-estimation in linear models with stable errors

稳定分布误差线性模型中的一步秩估计

Classical estimation techniques for linear models either are inconsistent, or perform rather poorly, under α-stable error densities; most of them are not even rate-optimal. In this paper, we propose an original one-step R-estimation method and investigate its asymptotic performances under stable densities. Contrary to traditional least squares, the proposed R-estimators remain root-n consistent (the optimal rate) under the whole family of stable distributions, irrespective…

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Robust Estimation for Homoscedastic Regression in the Secondary Analysis of Case–Control Data

病例对照数据二次分析中同方差回归的稳健估计

Summary Primary analysis of case–control studies focuses on the relationship between disease D and a set of covariates of interest (Y, X). A secondary application of the case–control study, which is often invoked in modern genetic epidemiologic association studies, is to investigate the interrelationship between the covariates themselves. The task is complicated owing to the case–control sampling, where the regression of Y on X is different from what it is in the population.…

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Mann–Whitney Test with Adjustments to Pretreatment Variables for Missing Values and Observational Study

针对缺失值与观察性研究进行处理前变量调整的Mann–Whitney检验

Summary The conventional Wilcoxon or Mann–Whitney test can be invalid for comparing treatment effects in the presence of missing values or in observational studies. This is because the missingness of the outcomes or the participation in the treatments may depend on certain pretreatment variables. We propose an approach to adjust the Mann–Whitney test by correcting the potential bias via consistently estimating the conditional distributions of the outcomes given the…

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Distribution free estimation of heteroskedastic binary response models using Probit/Logit criterion functions

利用 Probit/Logit 准则估计分布自由的异方差二元响应模型

In this paper estimators for distribution free heteroskedastic binary response models are proposed. The estimation procedures are based on relationships between distribution free models with a conditional median restriction and parametric models (such as Probit/Logit) exhibiting (multiplicative) heteroskedasticity. The first proposed estimator is based on the observational equivalence between the two models, and is a semiparametric sieve estimator (see, e.g. Gallant and…

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Robustness, Infinitesimal Neighborhoods, and Moment Restrictions

稳健性、无穷小邻域与矩限制

This paper is concerned with robust estimation under moment restrictions. A moment restriction model is semiparametric and distribution-free; therefore it imposes mild assumptions. Yet it is reasonable to expect that the probability law of observations may have some deviations from the ideal distribution being modeled, due to various factors such as measurement errors. It is then sensible to seek an estimation procedure that is robust against slight perturbation in the…

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Average and Quantile Effects in Nonseparable Panel Models

非可分面板模型中的平均效应与分位数效应

Nonseparable panel models are important in a variety of economic settings, including discrete choice. This paper gives identification and estimation results for nonseparable models under time-homogeneity conditions that are like “time is randomly assigned” or “time is an instrument.” Partial-identification results for average and quantile effects are given for discrete regressors, under static or dynamic conditions, in fully nonparametric and in semiparametric models, with…

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Asymptotic Variance of Semiparametric Estimators With Generated Regressors

含生成回归量的半参数估计量的渐近方差

We study the asymptotic distribution of three-step estimators of a finite-dimensional parameter vector where the second step consists of one or more nonparametric regressions on a regressor that is estimated in the first step. The first-step estimator is either parametric or nonparametric. Using Newey's (1994) path-derivative method, we derive the contribution of the first-step estimator to the influence function. In this derivation, it is important to account for the dual…

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