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Nonparametric Additive Instrumental Variable Estimator: A Group Shrinkage Estimation Perspective

非参数加性工具变量估计:组收缩估计视角

In this article, we study a nonparametric approach regarding a general nonlinear reduced form equation to achieve a better approximation of the optimal instrument. Accordingly, we propose the nonparametric additive instrumental variable estimator (NAIVE) with the adaptive group Lasso. We theoretically demonstrate that the proposed estimator is root-n consistent and asymptotically normal. The adaptive group Lasso helps us select the valid instruments while the dimensionality…

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Penalized indirect inference

惩罚化间接推断

Parameter estimates of structural economic models are often difficult to interpret at the light of the underlying economic theory. Bayesian methods have become increasingly popular as a tool for conducting inference on structural models since priors offer a way to exert control over the estimation results. Similarly to Bayesian estimation, this paper proposes a penalized indirect inference estimator that allows researchers to obtain economically meaningful parameter…

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‘Asymptotic properties of penalized spline estimators’

《惩罚样条估计量的渐近性质》勘误

Biometrika (2009) 96, pp. 529–44. In Lemmas A1 and A2, Theorem 2, and the line before equation (17), |$K_q\ge 1$| should be replaced by |$K_q\in[1,\infty)$|⁠, since |$K_q$| needs to be bounded. In Assumption 1, |$\delta=o(K^{-1})$| should read |$\max_{1\le j\le K}|\kappa_{j+1}-2\kappa_j+\kappa_{j-1}|=o(K^{-1})$|⁠. At the typesetting stage an error occurred while adding parentheses; throughout the paper it should be |$n^{1/(2q)-1}\lambda^{-1/(2q)}$| instead of |$n^{1/(2q-1)}\lambda^{-1/(2q)}$…

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Joint testing and false discovery rate control in high-dimensional multivariate regression

高维多元回归中的联合检验与错误发现率控制

Multivariate regression with high-dimensional covariates has many applications in genomic and genetic research, in which some covariates are expected to be associated with multiple responses. This paper considers joint testing for regression coefficients over multiple responses and develops simultaneous testing methods with false discovery rate control. The test statistic is based on inverse regression and bias-corrected group lasso estimates of the regression coefficients…

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Panning for Gold: ‘Model-X’ Knockoffs for High Dimensional Controlled Variable Selection

Summary Many contemporary large-scale applications involve building interpretable models linking a large set of potential covariates to a response in a non-linear fashion, such as when the response is binary. Although this modelling problem has been extensively studied, it remains unclear how to control the fraction of false discoveries effectively even in high dimensional logistic regression, not to mention general high dimensional non-linear models. To address such a…

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Are discoveries spurious? Distributions of maximum spurious correlations and their applications

发现是否虚假?最大虚假相关的分布及应用

Over the last two decades, many exciting variable selection methods have been developed for finding a small group of covariates that are associated with the response from a large pool. Can the discoveries from these data mining approaches be spurious due to high dimensionality and limited sample size? Can our fundamental assumptions about the exogeneity of the covariates needed for such variable selection be validated with the data? To answer these questions, we need to…

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High-dimensional $A$-learning for optimal dynamic treatment regimes

最优动态治疗方案的高维A-learning

Precision medicine is a medical paradigm that focuses on finding the most effective treatment decision based on individual patient information. For many complex diseases, such as cancer, treatment decisions need to be tailored over time according to patients' responses to previous treatments. Such an adaptive strategy is referred as a dynamic treatment regime. A major challenge in deriving an optimal dynamic treatment regime arises when an extraordinary large number of…

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Nested Hierarchical Functional Data Modeling and Inference for the Analysis of Functional Plant Phenotypes

植物功能表型分析的嵌套分层函数数据建模与推断

In a plant science Root Image Study, the process of seedling roots bending in response to gravity is recorded using digital cameras, and the bending rates are modeled as functional plant phenotype data. The functional phenotypes are collected from seeds representing a large variety of genotypes and have a three-level nested hierarchical structure, with seeds nested in groups nested in genotypes. The seeds are imaged on different days of the lunar cycle, and an important…

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Semiparametric Estimation of Longitudinal Medical Cost Trajectory

纵向医疗费用轨迹的半参数估计

Estimating the average monthly medical costs from disease diagnosis to a terminal event such as death for an incident cohort of patients is a topic of immense interest to researchers in health policy and health economics because patterns of average monthly costs over time reveal how medical costs vary across phases of care. The statistical challenges to estimating monthly medical costs longitudinally are multifold; the longitudinal cost trajectory (formed by plotting the…

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A Tailored Multivariate Mixture Model for Detecting Proteins of Concordant Change Among Virulent Strains of Clostridium Perfringens

识别产气荚膜梭菌致病菌株间一致变化蛋白的定制多元混合模型

Necrotic enteritis (NE) is a serious disease of poultry caused by the bacterium C. perfringens. To identify proteins of C. perfringens that confer virulence with respect to NE, the protein secretions of four NE disease-producing strains and one baseline nondisease-producing strain of C. perfringens were examined. The problem then becomes a clustering task, for the identification of two extreme groups of proteins that were produced at either concordantly higher or…

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A Unified Framework for Fitting Bayesian Semiparametric Models to Arbitrarily Censored Survival Data, Including Spatially Referenced Data

任意删失生存数据的贝叶斯半参数建模统一框架:兼顾空间信息

A comprehensive, unified approach to modeling arbitrarily censored spatial survival data is presented for the three most commonly used semiparametric models: proportional hazards, proportional odds, and accelerated failure time. Unlike many other approaches, all manner of censored survival times are simultaneously accommodated including uncensored, interval censored, current-status, left and right censored, and mixtures of these. Left-truncated data are also accommodated…

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Semiparametric Ultra-High Dimensional Model Averaging of Nonlinear Dynamic Time Series

非线性动态时间序列的半参数超高维模型平均

We propose two semiparametric model averaging schemes for nonlinear dynamic time series regression models with a very large number of covariates including exogenous regressors and auto-regressive lags. Our objective is to obtain more accurate estimates and forecasts of time series by using a large number of conditioning variables in a nonparametric way. In the first scheme, we introduce a kernel sure independence screening (KSIS) technique to screen out the regressors whose…

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Dimensionality Reduction and Variable Selection in Multivariate Varying-Coefficient Models With a Large Number of Covariates

多协变量多元变系数模型中的降维与变量选择

Motivated by the study of gene and environment interactions, we consider a multivariate response varying-coefficient model with a large number of covariates. The need of nonparametrically estimating a large number of coefficient functions given relatively limited data poses a big challenge for fitting such a model. To overcome the challenge, we develop a method that incorporates three ideas: (i) reduce the number of unknown functions to be estimated by using (noncentered)…

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Model Selection for High-Dimensional Quadratic Regression via Regularization

通过正则化进行高维二次回归模型选择

Quadratic regression (QR) models naturally extend linear models by considering interaction effects between the covariates. To conduct model selection in QR, it is important to maintain the hierarchical model structure between main effects and interaction effects. Existing regularization methods generally achieve this goal by solving complex optimization problems, which usually demands high computational cost and hence are not feasible for high-dimensional data. This article…

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Bayesian Regression Trees for High-Dimensional Prediction and Variable Selection

用于高维预测与变量选择的贝叶斯回归树

Decision tree ensembles are an extremely popular tool for obtaining high-quality predictions in nonparametric regression problems. Unmodified, however, many commonly used decision tree ensemble methods do not adapt to sparsity in the regime in which the number of predictors is larger than the number of observations. A recent stream of research concerns the construction of decision tree ensembles that are motivated by a generative probabilistic model, the most influential…

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Single-Index-Based CoVaR With Very High-Dimensional Covariates

超高维协变量下基于单指标模型的 CoVaR

Systemic risk analysis reveals the interdependencies of risk factors especially in tail event situations. In applications the focus of interest is on capturing joint tail behavior rather than a variation around the mean. Quantile and expectile regression are used here as tools of data analysis. When it comes to characterizing tail event curves one faces a dimensionality problem, which is important for CoVaR (Conditional Value at Risk) determination. A projection-based…

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Oracle inequalities for sparse additive quantile regression in reproducing kernel Hilbert space

再生核希尔伯特空间中稀疏加性分位数回归的预言不等式

This paper considers the estimation of the sparse additive quantile regression (SAQR) in high-dimensional settings. Given the nonsmooth nature of the quantile loss function and the nonparametric complexities of the component function estimation, it is challenging to analyze the theoretical properties of ultrahigh-dimensional SAQR. We propose a regularized learning approach with a two-fold Lasso-type regularization in a reproducing kernel Hilbert space (RKHS) for SAQR. We…

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Gaussian and bootstrap approximations for high-dimensional U-statistics and their applications

高维 U 统计量的高斯与自助法近似及其应用

This paper studies the Gaussian and bootstrap approximations for the probabilities of a nondegenerate U-statistic belonging to the hyperrectangles in $\mathbb{R}^{d}$ when the dimension $d$ is large. A two-step Gaussian approximation procedure that does not impose structural assumptions on the data distribution is proposed. Subject to mild moment conditions on the kernel, we establish the explicit rate of convergence uniformly in the class of all hyperrectangles in $\mathbb{R}^{d}$…

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Regularization and the small-ball method I: Sparse recovery

正则化与小球方法之一:稀疏恢复

We obtain bounds on estimation error rates for regularization procedures of the form \begin{equation*}\hat{f}\in\mathop{\operatorname{argmin}}_{f\in F}(\frac{1}{N}\sum_{i=1}^{N}(Y_{i}-f(X_{i}))^{2}+\lambda \Psi(f))\end{equation*} when $\Psi$ is a norm and $F$ is convex. Our approach gives a common framework that may be used in the analysis of learning problems and regularization problems alike. In particular, it sheds some light on the role various notions of sparsity have…

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I-LAMM for sparse learning: Simultaneous control of algorithmic complexity and statistical error

稀疏学习的 I-LAMM:同时控制算法复杂度与统计误差

We propose a computational framework named iterative local adaptive majorize-minimization (I-LAMM) to simultaneously control algorithmic complexity and statistical error when fitting high dimensional models. I-LAMM is a two-stage algorithmic implementation of the local linear approximation to a family of folded concave penalized quasi-likelihood. The first stage solves a convex program with a crude precision tolerance to obtain a coarse initial estimator, which is further…

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Scalar-on-image regression via the soft-thresholded Gaussian process

基于软阈值高斯过程的标量对图像回归

This work concerns spatial variable selection for scalar-on-image regression. We propose a new class of Bayesian nonparametric models and develop an efficient posterior computational aigorithm. The proposed soft-thresholded Gaussian process provides large prior support over the class of piecewise-smooth, sparse, and continuous spatially-varying regression coefficient functions. In addition, under some mild regularity conditions the soft-thresholded Gaussian proess prior…

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Robust and consistent variable selection in high-dimensional generalized linear models

高维广义线性模型中的稳健一致变量选择

Generalized linear models are popular for modelling a large variety of data. We consider variable selection through penalized methods by focusing on resistance issues in the presence of outlying data and other deviations from assumptions. We highlight the weaknesses of widely-used penalized M-estimators, propose a robust penalized quasilikelihood estimator, and show that it enjoys oracle properties in high dimensions and is stable in a neighbourhood of the model. We…

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Asymptotically honest confidence regions for high dimensional parameters by the desparsified conservative Lasso

基于去稀疏化保守 Lasso 的高维参数渐近诚实置信区域

In this paper we consider the conservative Lasso which we argue penalizes more correctly than the Lasso and show how it may be desparsified in the sense of van de Geer et al. (2014) in order to construct asymptotically honest (uniform) confidence bands. In particular, we develop an oracle inequality for the conservative Lasso only assuming the existence of a certain number of moments. This is done by means of the Marcinkiewicz–Zygmund inequality. We allow for heteroskedastic…

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Bayesian estimation of sparse signals with a continuous spike-and-slab prior

采用连续尖峰与厚尾混合先验的稀疏信号贝叶斯估计

We introduce a new framework for estimation of sparse normal means, bridging the gap between popular frequentist strategies (LASSO) and popular Bayesian strategies (spike-and-slab). The main thrust of this paper is to introduce the family of Spike-and-Slab LASSO (SS-LASSO) priors, which form a continuum between the Laplace prior and the point-mass spike-and-slab prior. We establish several appealing frequentist properties of SS-LASSO priors, contrasting them with these two…

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