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iProMix：利用整体蛋白质基因组数据研究 ACE2 功能的混合模型AI 解读

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over six million deaths in the ongoing COVID-19 pandemic. SARS-CoV-2 uses ACE2 protein to enter human cells, raising a pressing need to characterize proteins/pathways interacted with ACE2. Large-scale proteomic profiling technology is not mature at single-cell resolution to examine the protein activities in disease-relevant cell types. We propose iProMix, a novel statistical framework to identify…

基于最近邻方法的高维正态性检验AI 解读

Many statistical methodologies for high-dimensional data assume the population is normal. Although a few multivariate normality tests have been proposed, to the best of our knowledge, none of them can properly control the Type I error when the dimension is larger than the number of observations. In this work, we propose a novel nonparametric test that uses the nearest neighbor information. The proposed method guarantees the asymptotic Type I error control under the…

通过匹配恢复潜在变量AI 解读

We propose an optimal-transport-based matching method to nonparametrically estimate linear models with independent latent variables. The method consists in generating pseudo-observations from the latent variables, so that the Euclidean distance between the model’s predictions and their matched counterparts in the data is minimized. We show that our nonparametric estimator is consistent, and we document that it performs well in simulated data. We apply this method to study…

适用于空间依赖数据的随机森林AI 解读

Spatial linear mixed-models, consisting of a linear covariate effect and a Gaussian process (GP) distributed spatial random effect, are widely used for analyses of geospatial data. We consider the setting where the covariate effect is nonlinear. Random forests (RF) are popular for estimating nonlinear functions but applications of RF for spatial data have often ignored the spatial correlation. We show that this impacts the performance of RF adversely. We propose RF-GLS, a…

不完美随机实验中因果效应的非参数界AI 解读

Nonignorable missingness and noncompliance can occur even in well-designed randomized experiments, making the intervention effect that the experiment was designed to estimate nonidentifiable. Nonparametric causal bounds provide a way to narrow the range of possible values for a nonidentifiable causal effect with minimal assumptions. We derive novel bounds for the causal risk difference for a binary outcome and intervention in randomized experiments with nonignorable…

线性样条模型中的结点估计AI 解读

The linear spline model is able to accommodate nonlinear effects while allowing for an easy interpretation. It has significant applications in studying threshold effects and change-points. However, its application in practice has been limited by the lack of both rigorously studied and computationally convenient method for estimating knots. A key difficulty in estimating knots lies in the nondifferentiability. In this article, we study influence functions of regular and…

个体化群组学习AI 解读

Many massive data sets are assembled through collections of information of a large number of individuals in a population. The analysis of such data, especially in the aspect of individualized inferences and solutions, has the potential to create significant value for practical applications. Traditionally, inference for an individual in the dataset is either solely relying on the information of the individual or from summarizing the information about the whole population.…

适应模型的回归检验混合方法AI 解读

In model checking for regressions, nonparametric estimation-based tests usually have tractable limiting null distributions and are sensitive to oscillating alternative models, but suffer from the curse of dimensionality. In contrast, empirical process-based tests can, at the fastest possible rate, detect local alternatives distinct from the null model, yet are less sensitive to oscillating alternatives and rely on Monte Carlo approximation for critical value determination,…

动态交互半参数函数对标量回归模型AI 解读

Motivated by recent work studying massive functional data, such as the COVID-19 data, we propose a new dynamic interaction semiparametric function-on-scalar (DISeF) model. The proposed model is useful to explore the dynamic interaction among a set of covariates and their effects on the functional response. The proposed model includes many important models investigated recently as special cases. By tensor product B-spline approximating the unknown bivariate coefficient…

凸性约束单指标模型中的半参数效率AI 解读

We consider estimation and inference in a single-index regression model with an unknown convex link function. We introduce a convex and Lipschitz constrained least-square estimator (CLSE) for both the parametric and the nonparametric components given independent and identically distributed observations. We prove the consistency and find the rates of convergence of the CLSE when the errors are assumed to have only q≥2 moments and are allowed to depend on the covariates. When…

通过投影与收缩构造高维回归的诚实置信集AI 解读

The issue of honesty in constructing confidence sets arises in nonparametric regression. While optimal rate in nonparametric estimation can be achieved and utilized to construct sharp confidence sets, severe degradation of confidence level often happens after estimating the degree of smoothness. Similarly, for high-dimensional regression, oracle inequalities for sparse estimators could be utilized to construct sharp confidence sets. Yet the degree of sparsity itself is…

分布单指标模型AI 解读

A Distributional (Single) Index Model (DIM) is a semiparametric model for distributional regression, that is, estimation of conditional distributions given covariates. The method is a combination of classical single-index models for the estimation of the conditional mean of a response given covariates, and isotonic distributional regression. The model for the index is parametric, whereas the conditional distributions are estimated nonparametrically under a stochastic…

用于嵌套数据贝叶斯非参数分析的共同原子模型AI 解读

The use of large datasets for targeted therapeutic interventions requires new ways to characterize the heterogeneity observed across subgroups of a specific population. In particular, models for partially exchangeable data are needed for inference on nested datasets, where the observations are assumed to be organized in different units and some sharing of information is required to learn distinctive features of the units. In this manuscript, we propose a nested common atoms…

高维最优治疗规则的模型辅助一致诚实推断AI 解读

This article develops new tools to quantify uncertainty in optimal decision making and to gain insight into which variables one should collect information about given the potential cost of measuring a large number of variables. We investigate simultaneous inference to determine if a group of variables is relevant for estimating an optimal decision rule in a high-dimensional semiparametric framework. The unknown link function permits flexible modeling of the interactions…

通过 Thompson 抽样进行变量选择AI 解读

–Thompson sampling is a heuristic algorithm for the multi-armed bandit problem which has a long tradition in machine learning. The algorithm has a Bayesian spirit in the sense that it selects arms based on posterior samples of reward probabilities of each arm. By forging a connection between combinatorial binary bandits and spike-and-slab variable selection, we propose a stochastic optimization approach to subset selection called Thompson variable selection (TVS). TVS is a…

基于测度输运的多元秩无分布非参数检验AI 解读

In this article, we propose a general framework for distribution-free nonparametric testing in multi-dimensions, based on a notion of multivariate ranks defined using the theory of measure transportation. Unlike other existing proposals in the literature, these multivariate ranks share a number of useful properties with the usual one-dimensional ranks; most importantly, these ranks are distribution-free. This crucial observation allows us to design nonparametric tests that…

基于分位数的众数回归自助法推断AI 解读

In this article, we develop uniform inference methods for the conditional mode based on quantile regression. Specifically, we propose to estimate the conditional mode by minimizing the derivative of the estimated conditional quantile function defined by smoothing the linear quantile regression estimator, and develop two bootstrap methods, a novel pivotal bootstrap and the nonparametric bootstrap, for our conditional mode estimator. Building on high-dimensional Gaussian…

核平均估计量AI 解读

The issue of bandwidth selection is a fundamental model selection problem stemming from the uncertainty about the smoothness of the regression. In this article, we advocate a model averaging approach to circumvent the problem caused by this uncertainty. Our new approach involves averaging across a series of Nadaraya-Watson kernel estimators each under a different bandwidth, with weights for these different estimators chosen such that a least-squares cross-validation…

倾向得分估计中的最优协变量平衡条件AI 解读

Inverse probability of treatment weighting (IPTW) is a popular method for estimating the average treatment effect (ATE). However, empirical studies show that the IPTW estimators can be sensitive to the misspecification of the propensity score model. To address this problem, researchers have proposed to estimate propensity score by directly optimizing the balance of pretreatment covariates. While these methods appear to empirically perform well, little is known about how the…

疫情时间趋势的非参数比较：COVID-19 案例AI 解读

The COVID-19 pandemic is one of the most pressing issues at present. A question which is particularly important for governments and policy makers is the following: Does the virus spread in the same way in different countries? Or are there significant differences in the development of the epidemic? In this paper, we devise new inference methods that allow to detect differences in the development of the COVID-19 epidemic across countries in a statistically rigorous way. In our…

疫情期间利用非参数混频 VAR 进行即时预测AI 解读

This paper develops Bayesian econometric methods for posterior inference in non-parametric mixed frequency VARs using additive regression trees. We argue that regression tree models are ideally suited for macroeconomic nowcasting in the face of extreme observations, for instance those produced by the COVID-19 pandemic of 2020. This is due to their flexibility and ability to model outliers. In an application involving four major euro area countries, we find substantial…

COVID-19 感染曲线的时间序列分析：变点视角AI 解读

In this paper, we model the trajectory of the cumulative confirmed cases and deaths of COVID-19 (in log scale) via a piecewise linear trend model. The model naturally captures the phase transitions of the epidemic growth rate via change-points and further enjoys great interpretability due to its semiparametric nature. On the methodological front, we advance the nascent self-normalization (SN) technique (Shao, 2010) to testing and estimation of a single change-point in the…

外资所有权的动态与非中性生产率效应：非参数方法AI 解读

Summary This paper studies two novel productivity characteristics of foreign acquisition on high‐tech manufacturing firms: the dynamic and the non‐Hicks‐neutral effects. A dynamic productivity effect of foreign ownership arises when adoption of foreign technology and management practices takes time to fully realize. Furthermore, these dynamic adjustments may be capital or labor augmenting as adoption of advanced production technologies tends to have non‐neutral productivity…

无限维与维度增长时间序列回归的稳健推断AI 解读

We develop a class of tests for time‐series models such as multiple regression with growing dimension, infinite‐order autoregression, and nonparametric sieve regression. Examples include the Chow test and general linear restriction tests of growing rank p . Employing such increasing p asymptotics, we introduce a new scale correction to conventional test statistics, which accounts for a high‐order long‐run variance (HLV), which emerges as p grows with sample size. We also…